Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis

Abstract Allergic rhinitis (AR) is the most common undiagnosed chronic condition in children. Moderate/severe AR symptoms significantly impair quality of life, and cause sleep disruption, absenteeism and decreased productivity. Additionally, untreated AR predisposes children to asthma and other chro...

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Autores principales:	Eli O. Meltzer, Nelson Augusto Rosario, Hugo Van Bever, Luiz Lucio
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Allergic rhinitis Fexofenadine Pediatrics Quality of life Second-generation antihistamines Sedative effect Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d936cc061a9140dda48eb5681311d5e0
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spelling	oai:doaj.org-article:d936cc061a9140dda48eb5681311d5e02021-11-08T11:13:17ZFexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis10.1186/s13223-021-00614-61710-1492https://doaj.org/article/d936cc061a9140dda48eb5681311d5e02021-11-01T00:00:00Zhttps://doi.org/10.1186/s13223-021-00614-6https://doaj.org/toc/1710-1492Abstract Allergic rhinitis (AR) is the most common undiagnosed chronic condition in children. Moderate/severe AR symptoms significantly impair quality of life, and cause sleep disruption, absenteeism and decreased productivity. Additionally, untreated AR predisposes children to asthma and other chronic conditions. Although intranasal corticosteroids are the most effective pharmacologic treatment for AR, oral antihistamines are often preferred. First-generation antihistamines may be chosen to relieve AR symptoms as they are inexpensive and widely available; however, they cause sedative and cardiovascular negative effects due to poor receptor selectivity. Therefore, second-generation antihistamines were developed to reduce adverse effects while retaining efficacy. There are fewer clinical trials in children than adults, therefore, efficacy and safety data is limited, particularly in children under 6 years, highlighting the need to generate these data in young children with AR. Fexofenadine, a highly selective second-generation antihistamine, effectively alleviates symptoms of AR, is non-sedating due to decreased blood–brain barrier permeability, and is devoid of cardiovascular side effects. Importantly, fexofenadine relieves the ocular symptoms of allergic conjunctivitis, which occur concomitantly with AR, improving quality of life. Overall, fexofenadine displays a favorable safety profile and results in greater treatment satisfaction in children compared with other second-generation antihistamines. This review aimed to evaluate and compare the safety and efficacy of fexofenadine with other available first- and second-generation antihistamines in children with AR.Eli O. MeltzerNelson Augusto RosarioHugo Van BeverLuiz LucioBMCarticleAllergic rhinitisFexofenadinePediatricsQuality of lifeSecond-generation antihistaminesSedative effectImmunologic diseases. AllergyRC581-607ENAllergy, Asthma & Clinical Immunology, Vol 17, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Allergic rhinitis Fexofenadine Pediatrics Quality of life Second-generation antihistamines Sedative effect Immunologic diseases. Allergy RC581-607
spellingShingle	Allergic rhinitis Fexofenadine Pediatrics Quality of life Second-generation antihistamines Sedative effect Immunologic diseases. Allergy RC581-607 Eli O. Meltzer Nelson Augusto Rosario Hugo Van Bever Luiz Lucio Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis
description	Abstract Allergic rhinitis (AR) is the most common undiagnosed chronic condition in children. Moderate/severe AR symptoms significantly impair quality of life, and cause sleep disruption, absenteeism and decreased productivity. Additionally, untreated AR predisposes children to asthma and other chronic conditions. Although intranasal corticosteroids are the most effective pharmacologic treatment for AR, oral antihistamines are often preferred. First-generation antihistamines may be chosen to relieve AR symptoms as they are inexpensive and widely available; however, they cause sedative and cardiovascular negative effects due to poor receptor selectivity. Therefore, second-generation antihistamines were developed to reduce adverse effects while retaining efficacy. There are fewer clinical trials in children than adults, therefore, efficacy and safety data is limited, particularly in children under 6 years, highlighting the need to generate these data in young children with AR. Fexofenadine, a highly selective second-generation antihistamine, effectively alleviates symptoms of AR, is non-sedating due to decreased blood–brain barrier permeability, and is devoid of cardiovascular side effects. Importantly, fexofenadine relieves the ocular symptoms of allergic conjunctivitis, which occur concomitantly with AR, improving quality of life. Overall, fexofenadine displays a favorable safety profile and results in greater treatment satisfaction in children compared with other second-generation antihistamines. This review aimed to evaluate and compare the safety and efficacy of fexofenadine with other available first- and second-generation antihistamines in children with AR.
format	article
author	Eli O. Meltzer Nelson Augusto Rosario Hugo Van Bever Luiz Lucio
author_facet	Eli O. Meltzer Nelson Augusto Rosario Hugo Van Bever Luiz Lucio
author_sort	Eli O. Meltzer
title	Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis
title_short	Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis
title_full	Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis
title_fullStr	Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis
title_full_unstemmed	Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis
title_sort	fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/d936cc061a9140dda48eb5681311d5e0
work_keys_str_mv	AT eliomeltzer fexofenadinereviewofsafetyefficacyandunmetneedsinchildrenwithallergicrhinitis AT nelsonaugustorosario fexofenadinereviewofsafetyefficacyandunmetneedsinchildrenwithallergicrhinitis AT hugovanbever fexofenadinereviewofsafetyefficacyandunmetneedsinchildrenwithallergicrhinitis AT luizlucio fexofenadinereviewofsafetyefficacyandunmetneedsinchildrenwithallergicrhinitis
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Fexofenadine: review of safety, efficacy and unmet needs in children with allergic rhinitis

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