Evaluation of the Abbott ARCHITECT HIV Ag/Ab combo assay for determining recent HIV-1 infection.
<h4>Background</h4>Given the challenges and costs associated with implementing HIV-1 incidence assay testing, there is great interest in evaluating the use of commercial HIV diagnostic tests for determining recent HIV infection. A diagnostic test with the capability of providing reliable...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d93daca3fe5648539f7b2abba40466f4 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d93daca3fe5648539f7b2abba40466f4 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d93daca3fe5648539f7b2abba40466f42021-12-02T20:05:17ZEvaluation of the Abbott ARCHITECT HIV Ag/Ab combo assay for determining recent HIV-1 infection.1932-620310.1371/journal.pone.0242641https://doaj.org/article/d93daca3fe5648539f7b2abba40466f42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0242641https://doaj.org/toc/1932-6203<h4>Background</h4>Given the challenges and costs associated with implementing HIV-1 incidence assay testing, there is great interest in evaluating the use of commercial HIV diagnostic tests for determining recent HIV infection. A diagnostic test with the capability of providing reliable data for the determination of recent HIV infection without substantial modifications to the test protocol would have a significant impact on HIV surveillance. The Abbott ARCHITECT HIV Ag/Ab Combo Assay is an antigen/antibody immunoassay, which meets the criteria as the first screening test in the recommended HIV laboratory diagnostic algorithm for the United States.<h4>Methods</h4>In this study, we evaluated the performance characteristics of the ARCHITECT HIV Ag/Ab Combo signal-to-cutoff ratio (S/Co) for determining recent infection, including estimation of the mean duration of recent infection (MDRI) and false recent rate (FRR), and selection of recency cutoffs.<h4>Results</h4>The MDRI estimates for the S/Co recency cutoff of 400 is within the 4 to 12 months range recommended for HIV incidence assays, and the FRR rate for this cutoff was 1.5%. Additionally, ARCHITECT Combo S/Co values were compared relative to diagnostic test results from two prior prospective HIV-1 diagnostic studies in order to validate the use of the S/Co for both diagnostic and recency determination.<h4>Conclusion</h4>Dual-use of the ARCHITECT Combo assay data for diagnostic and incidence purposes would reduce the need for separate HIV incidence testing and allow for monitoring of recent infection for incidence estimation and other public health applications.Kelly A CurtisDonna L RudolphYi PanKevin DelaneyKathryn AnastosJack DeHovitzSeble G KassayeCarl V HansonAudrey L FrenchElizabeth GolubAdaora A AdimoraIgho OfotokunHector BolivarMirjam-Colette KempfPhilip J PetersWilliam M SwitzerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0242641 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Kelly A Curtis Donna L Rudolph Yi Pan Kevin Delaney Kathryn Anastos Jack DeHovitz Seble G Kassaye Carl V Hanson Audrey L French Elizabeth Golub Adaora A Adimora Igho Ofotokun Hector Bolivar Mirjam-Colette Kempf Philip J Peters William M Switzer Evaluation of the Abbott ARCHITECT HIV Ag/Ab combo assay for determining recent HIV-1 infection. |
| description |
<h4>Background</h4>Given the challenges and costs associated with implementing HIV-1 incidence assay testing, there is great interest in evaluating the use of commercial HIV diagnostic tests for determining recent HIV infection. A diagnostic test with the capability of providing reliable data for the determination of recent HIV infection without substantial modifications to the test protocol would have a significant impact on HIV surveillance. The Abbott ARCHITECT HIV Ag/Ab Combo Assay is an antigen/antibody immunoassay, which meets the criteria as the first screening test in the recommended HIV laboratory diagnostic algorithm for the United States.<h4>Methods</h4>In this study, we evaluated the performance characteristics of the ARCHITECT HIV Ag/Ab Combo signal-to-cutoff ratio (S/Co) for determining recent infection, including estimation of the mean duration of recent infection (MDRI) and false recent rate (FRR), and selection of recency cutoffs.<h4>Results</h4>The MDRI estimates for the S/Co recency cutoff of 400 is within the 4 to 12 months range recommended for HIV incidence assays, and the FRR rate for this cutoff was 1.5%. Additionally, ARCHITECT Combo S/Co values were compared relative to diagnostic test results from two prior prospective HIV-1 diagnostic studies in order to validate the use of the S/Co for both diagnostic and recency determination.<h4>Conclusion</h4>Dual-use of the ARCHITECT Combo assay data for diagnostic and incidence purposes would reduce the need for separate HIV incidence testing and allow for monitoring of recent infection for incidence estimation and other public health applications. |
| format |
article |
| author |
Kelly A Curtis Donna L Rudolph Yi Pan Kevin Delaney Kathryn Anastos Jack DeHovitz Seble G Kassaye Carl V Hanson Audrey L French Elizabeth Golub Adaora A Adimora Igho Ofotokun Hector Bolivar Mirjam-Colette Kempf Philip J Peters William M Switzer |
| author_facet |
Kelly A Curtis Donna L Rudolph Yi Pan Kevin Delaney Kathryn Anastos Jack DeHovitz Seble G Kassaye Carl V Hanson Audrey L French Elizabeth Golub Adaora A Adimora Igho Ofotokun Hector Bolivar Mirjam-Colette Kempf Philip J Peters William M Switzer |
| author_sort |
Kelly A Curtis |
| title |
Evaluation of the Abbott ARCHITECT HIV Ag/Ab combo assay for determining recent HIV-1 infection. |
| title_short |
Evaluation of the Abbott ARCHITECT HIV Ag/Ab combo assay for determining recent HIV-1 infection. |
| title_full |
Evaluation of the Abbott ARCHITECT HIV Ag/Ab combo assay for determining recent HIV-1 infection. |
| title_fullStr |
Evaluation of the Abbott ARCHITECT HIV Ag/Ab combo assay for determining recent HIV-1 infection. |
| title_full_unstemmed |
Evaluation of the Abbott ARCHITECT HIV Ag/Ab combo assay for determining recent HIV-1 infection. |
| title_sort |
evaluation of the abbott architect hiv ag/ab combo assay for determining recent hiv-1 infection. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/d93daca3fe5648539f7b2abba40466f4 |
| work_keys_str_mv |
AT kellyacurtis evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT donnalrudolph evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT yipan evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT kevindelaney evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT kathrynanastos evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT jackdehovitz evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT seblegkassaye evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT carlvhanson evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT audreylfrench evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT elizabethgolub evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT adaoraaadimora evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT ighoofotokun evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT hectorbolivar evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT mirjamcolettekempf evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT philipjpeters evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection AT williammswitzer evaluationoftheabbottarchitecthivagabcomboassayfordeterminingrecenthiv1infection |
| _version_ |
1718375510404235264 |