Serum asprosin levels are associated with obesity and insulin resistance in Arab adults

Background: Asprosin, a novel adipokine, has been implicated in glucose regulation, insulin production, and appetite stimulation. Hence, the current study explores circulating asprosin levels and their associations with insulin resistance (IR) and other parameters in obese and type 2 diabetes mellit...

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Autores principales:	Nasser M. Al-Daghri, Reem M.I. Alokeel, Abir Alamro, Mohammed G.A. Ansari, Syed D. Hussain, Osama E. Amer, Sobhy M. Yakout, Abdullah M. Alnaami, Shaun Sabico
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Asprosin Obesity Insulin resistance Biomarker Saudi Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/d93e1554f7924b519277d05f2e9ea057
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spelling	oai:doaj.org-article:d93e1554f7924b519277d05f2e9ea0572021-11-20T04:56:05ZSerum asprosin levels are associated with obesity and insulin resistance in Arab adults1018-364710.1016/j.jksus.2021.101690https://doaj.org/article/d93e1554f7924b519277d05f2e9ea0572022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003529https://doaj.org/toc/1018-3647Background: Asprosin, a novel adipokine, has been implicated in glucose regulation, insulin production, and appetite stimulation. Hence, the current study explores circulating asprosin levels and their associations with insulin resistance (IR) and other parameters in obese and type 2 diabetes mellitus (T2DM) Saudi subjects. Methods: A total of N = 291 (89 control, 105 T2DM/obese and 97 obese) subjects were included in this cross-sectional study. Fasting glucose and lipid profiles were measured routinely. Adiponectin, leptin, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1, and asprosin were measured using commercially available assays. Results: Serum asprosin levels were found to be significantly highest in obese subjects [3.7 ng/ml (2.6–5.0)] than T2DM/obese [0.1 ng/ml (0.0–0.4)] and controls [0.2 ng/ml (0.1–0.3)] (p < 0.001). In the T2DM/obese group, users of metformin alone or in combination had significantly lower asprosin levels than those whose medication history was unknown [0.03 ng/ml (0.02–0.05) versus 0.2 ng/ml (0.1–0.4); p < 0.001]. Stepwise multiple linear regression analysis revealed that only glucose, insulin and adiponectin were the most important predictors of asprosin, explaining 61.3% (p < 0.001) of the variances perceived. Conclusion: Asprosin levels are associated with markers of IR independent of adiposity and inflammation and are influenced by oral hypoglycemics, particularly metformin.Nasser M. Al-DaghriReem M.I. AlokeelAbir AlamroMohammed G.A. AnsariSyed D. HussainOsama E. AmerSobhy M. YakoutAbdullah M. AlnaamiShaun SabicoElsevierarticleAsprosinObesityInsulin resistanceBiomarkerSaudiScience (General)Q1-390ENJournal of King Saud University: Science, Vol 34, Iss 1, Pp 101690- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Asprosin Obesity Insulin resistance Biomarker Saudi Science (General) Q1-390
spellingShingle	Asprosin Obesity Insulin resistance Biomarker Saudi Science (General) Q1-390 Nasser M. Al-Daghri Reem M.I. Alokeel Abir Alamro Mohammed G.A. Ansari Syed D. Hussain Osama E. Amer Sobhy M. Yakout Abdullah M. Alnaami Shaun Sabico Serum asprosin levels are associated with obesity and insulin resistance in Arab adults
description	Background: Asprosin, a novel adipokine, has been implicated in glucose regulation, insulin production, and appetite stimulation. Hence, the current study explores circulating asprosin levels and their associations with insulin resistance (IR) and other parameters in obese and type 2 diabetes mellitus (T2DM) Saudi subjects. Methods: A total of N = 291 (89 control, 105 T2DM/obese and 97 obese) subjects were included in this cross-sectional study. Fasting glucose and lipid profiles were measured routinely. Adiponectin, leptin, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1, and asprosin were measured using commercially available assays. Results: Serum asprosin levels were found to be significantly highest in obese subjects [3.7 ng/ml (2.6–5.0)] than T2DM/obese [0.1 ng/ml (0.0–0.4)] and controls [0.2 ng/ml (0.1–0.3)] (p < 0.001). In the T2DM/obese group, users of metformin alone or in combination had significantly lower asprosin levels than those whose medication history was unknown [0.03 ng/ml (0.02–0.05) versus 0.2 ng/ml (0.1–0.4); p < 0.001]. Stepwise multiple linear regression analysis revealed that only glucose, insulin and adiponectin were the most important predictors of asprosin, explaining 61.3% (p < 0.001) of the variances perceived. Conclusion: Asprosin levels are associated with markers of IR independent of adiposity and inflammation and are influenced by oral hypoglycemics, particularly metformin.
format	article
author	Nasser M. Al-Daghri Reem M.I. Alokeel Abir Alamro Mohammed G.A. Ansari Syed D. Hussain Osama E. Amer Sobhy M. Yakout Abdullah M. Alnaami Shaun Sabico
author_facet	Nasser M. Al-Daghri Reem M.I. Alokeel Abir Alamro Mohammed G.A. Ansari Syed D. Hussain Osama E. Amer Sobhy M. Yakout Abdullah M. Alnaami Shaun Sabico
author_sort	Nasser M. Al-Daghri
title	Serum asprosin levels are associated with obesity and insulin resistance in Arab adults
title_short	Serum asprosin levels are associated with obesity and insulin resistance in Arab adults
title_full	Serum asprosin levels are associated with obesity and insulin resistance in Arab adults
title_fullStr	Serum asprosin levels are associated with obesity and insulin resistance in Arab adults
title_full_unstemmed	Serum asprosin levels are associated with obesity and insulin resistance in Arab adults
title_sort	serum asprosin levels are associated with obesity and insulin resistance in arab adults
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/d93e1554f7924b519277d05f2e9ea057
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Serum asprosin levels are associated with obesity and insulin resistance in Arab adults

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