Progress in Nanocarriers Codelivery System to Enhance the Anticancer Effect of Photodynamic Therapy

Photodynamic therapy (PDT) is a promising anticancer noninvasive method and has great potential for clinical applications. Unfortunately, PDT still has many limitations, such as metastatic tumor at unknown sites, inadequate light delivery and a lack of sufficient oxygen. Recent studies have demonstr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yu-Ling Yang, Ke Lin, Li Yang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	codelivery nanocarriers photodynamic therapy anticancer therapies combination therapy Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/d9419bfb755146a5b962a5b90ffc0857
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d9419bfb755146a5b962a5b90ffc0857
record_format	dspace
spelling	oai:doaj.org-article:d9419bfb755146a5b962a5b90ffc08572021-11-25T18:42:19ZProgress in Nanocarriers Codelivery System to Enhance the Anticancer Effect of Photodynamic Therapy10.3390/pharmaceutics131119511999-4923https://doaj.org/article/d9419bfb755146a5b962a5b90ffc08572021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1951https://doaj.org/toc/1999-4923Photodynamic therapy (PDT) is a promising anticancer noninvasive method and has great potential for clinical applications. Unfortunately, PDT still has many limitations, such as metastatic tumor at unknown sites, inadequate light delivery and a lack of sufficient oxygen. Recent studies have demonstrated that photodynamic therapy in combination with other therapies can enhance anticancer effects. The development of new nanomaterials provides a platform for the codelivery of two or more therapeutic drugs, which is a promising cancer treatment method. The use of multifunctional nanocarriers for the codelivery of two or more drugs can improve physical and chemical properties, increase tumor site aggregation, and enhance the antitumor effect through synergistic actions, which is worthy of further study. This review focuses on the latest research progress on the synergistic enhancement of PDT by simultaneous multidrug administration using codelivery nanocarriers. We introduce the design of codelivery nanocarriers and discuss the mechanism of PDT combined with other antitumor methods. The combination of PDT and chemotherapy, gene therapy, immunotherapy, photothermal therapy, hyperthermia, radiotherapy, sonodynamic therapy and even multidrug therapy are discussed to provide a comprehensive understanding.Yu-Ling YangKe LinLi YangMDPI AGarticlecodelivery nanocarriersphotodynamic therapyanticancer therapiescombination therapyPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1951, p 1951 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	codelivery nanocarriers photodynamic therapy anticancer therapies combination therapy Pharmacy and materia medica RS1-441
spellingShingle	codelivery nanocarriers photodynamic therapy anticancer therapies combination therapy Pharmacy and materia medica RS1-441 Yu-Ling Yang Ke Lin Li Yang Progress in Nanocarriers Codelivery System to Enhance the Anticancer Effect of Photodynamic Therapy
description	Photodynamic therapy (PDT) is a promising anticancer noninvasive method and has great potential for clinical applications. Unfortunately, PDT still has many limitations, such as metastatic tumor at unknown sites, inadequate light delivery and a lack of sufficient oxygen. Recent studies have demonstrated that photodynamic therapy in combination with other therapies can enhance anticancer effects. The development of new nanomaterials provides a platform for the codelivery of two or more therapeutic drugs, which is a promising cancer treatment method. The use of multifunctional nanocarriers for the codelivery of two or more drugs can improve physical and chemical properties, increase tumor site aggregation, and enhance the antitumor effect through synergistic actions, which is worthy of further study. This review focuses on the latest research progress on the synergistic enhancement of PDT by simultaneous multidrug administration using codelivery nanocarriers. We introduce the design of codelivery nanocarriers and discuss the mechanism of PDT combined with other antitumor methods. The combination of PDT and chemotherapy, gene therapy, immunotherapy, photothermal therapy, hyperthermia, radiotherapy, sonodynamic therapy and even multidrug therapy are discussed to provide a comprehensive understanding.
format	article
author	Yu-Ling Yang Ke Lin Li Yang
author_facet	Yu-Ling Yang Ke Lin Li Yang
author_sort	Yu-Ling Yang
title	Progress in Nanocarriers Codelivery System to Enhance the Anticancer Effect of Photodynamic Therapy
title_short	Progress in Nanocarriers Codelivery System to Enhance the Anticancer Effect of Photodynamic Therapy
title_full	Progress in Nanocarriers Codelivery System to Enhance the Anticancer Effect of Photodynamic Therapy
title_fullStr	Progress in Nanocarriers Codelivery System to Enhance the Anticancer Effect of Photodynamic Therapy
title_full_unstemmed	Progress in Nanocarriers Codelivery System to Enhance the Anticancer Effect of Photodynamic Therapy
title_sort	progress in nanocarriers codelivery system to enhance the anticancer effect of photodynamic therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d9419bfb755146a5b962a5b90ffc0857
work_keys_str_mv	AT yulingyang progressinnanocarrierscodeliverysystemtoenhancetheanticancereffectofphotodynamictherapy AT kelin progressinnanocarrierscodeliverysystemtoenhancetheanticancereffectofphotodynamictherapy AT liyang progressinnanocarrierscodeliverysystemtoenhancetheanticancereffectofphotodynamictherapy
_version_	1718410803613270016

Progress in Nanocarriers Codelivery System to Enhance the Anticancer Effect of Photodynamic Therapy

Ejemplares similares