Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases

Mesenchymal stromal cells (MSCs) are a mesodermal stem cell population, with known self-renewal and multilineage differentiation properties. In the last century, MSCs have been widely used in regenerative medicine and tissue engineering approaches. MSCs initially were isolated from bone marrow aspir...

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Autores principales:	Panagiotis Mallis, Efstathios Michalopoulos, Theofanis Chatzistamatiou, Catherine Stavropoulos Giokas
Formato:	article
Lenguaje:	EN
Publicado:	Open Exploration Publishing Inc. 2021
Materias:	mesenchymal stromal cells immunomodulation adaptive immunity graft versus host disease autoimmune disorders covid-19 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d941e78d1e4b4652af18478cca33e576
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spelling	oai:doaj.org-article:d941e78d1e4b4652af18478cca33e5762021-11-24T06:00:16ZInterplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases10.37349/ei.2021.000102768-6655https://doaj.org/article/d941e78d1e4b4652af18478cca33e5762021-06-01T00:00:00Zhttps://www.explorationpub.com/Journals/ei/Article/100310https://doaj.org/toc/2768-6655Mesenchymal stromal cells (MSCs) are a mesodermal stem cell population, with known self-renewal and multilineage differentiation properties. In the last century, MSCs have been widely used in regenerative medicine and tissue engineering approaches. MSCs initially were isolated from bone marrow aspirates, but currently have been identified in a great number of tissues of the human body. Besides their utilization in regenerative medicine, MSCs possess significant immunoregulatory/immunosuppressive properties, through interaction with the cells of innate and adaptive immunity. MSCs can exert their immunomodulatory properties with either cell-cell contact or via paracrine secretion of molecules, such as cytokines, growth factors and chemokines. Of particular importance, the MSCs’ immunomodulatory properties are explored as promising therapeutic strategies in immune-related disorders, such as autoimmune diseases, graft versus host disease, cancer. MSCs may also have an additional impact on coronavirus disease-19 (COVID-19), by attenuating the severe symptoms of this disorder. Nowadays, a great number of clinical trials, of MSC-mediated therapies are evaluated for their therapeutic potential. In this review, the current knowledge on cellular and molecular mechanisms involved in MSC-mediated immunomodulation were highlighted. Also, the most important aspects, regarding their potential application in immune-related diseases, will be highlighted. The broad application of MSCs has emerged their role as key immunomodulatory players, therefore their utilization in many disease situations is full of possibilities for future clinical treatment.Panagiotis MallisEfstathios MichalopoulosTheofanis ChatzistamatiouCatherine Stavropoulos GiokasOpen Exploration Publishing Inc.articlemesenchymal stromal cellsimmunomodulationadaptive immunitygraft versus host diseaseautoimmune disorderscovid-19Immunologic diseases. AllergyRC581-607ENExploration of Immunology, Vol 1, Iss 2, Pp 112-139 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesenchymal stromal cells immunomodulation adaptive immunity graft versus host disease autoimmune disorders covid-19 Immunologic diseases. Allergy RC581-607
spellingShingle	mesenchymal stromal cells immunomodulation adaptive immunity graft versus host disease autoimmune disorders covid-19 Immunologic diseases. Allergy RC581-607 Panagiotis Mallis Efstathios Michalopoulos Theofanis Chatzistamatiou Catherine Stavropoulos Giokas Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
description	Mesenchymal stromal cells (MSCs) are a mesodermal stem cell population, with known self-renewal and multilineage differentiation properties. In the last century, MSCs have been widely used in regenerative medicine and tissue engineering approaches. MSCs initially were isolated from bone marrow aspirates, but currently have been identified in a great number of tissues of the human body. Besides their utilization in regenerative medicine, MSCs possess significant immunoregulatory/immunosuppressive properties, through interaction with the cells of innate and adaptive immunity. MSCs can exert their immunomodulatory properties with either cell-cell contact or via paracrine secretion of molecules, such as cytokines, growth factors and chemokines. Of particular importance, the MSCs’ immunomodulatory properties are explored as promising therapeutic strategies in immune-related disorders, such as autoimmune diseases, graft versus host disease, cancer. MSCs may also have an additional impact on coronavirus disease-19 (COVID-19), by attenuating the severe symptoms of this disorder. Nowadays, a great number of clinical trials, of MSC-mediated therapies are evaluated for their therapeutic potential. In this review, the current knowledge on cellular and molecular mechanisms involved in MSC-mediated immunomodulation were highlighted. Also, the most important aspects, regarding their potential application in immune-related diseases, will be highlighted. The broad application of MSCs has emerged their role as key immunomodulatory players, therefore their utilization in many disease situations is full of possibilities for future clinical treatment.
format	article
author	Panagiotis Mallis Efstathios Michalopoulos Theofanis Chatzistamatiou Catherine Stavropoulos Giokas
author_facet	Panagiotis Mallis Efstathios Michalopoulos Theofanis Chatzistamatiou Catherine Stavropoulos Giokas
author_sort	Panagiotis Mallis
title	Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
title_short	Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
title_full	Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
title_fullStr	Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
title_full_unstemmed	Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
title_sort	interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases
publisher	Open Exploration Publishing Inc.
publishDate	2021
url	https://doaj.org/article/d941e78d1e4b4652af18478cca33e576
work_keys_str_mv	AT panagiotismallis interplaybetweenmesenchymalstromalcellsandimmunesystemclinicalapplicationsinimmunerelateddiseases AT efstathiosmichalopoulos interplaybetweenmesenchymalstromalcellsandimmunesystemclinicalapplicationsinimmunerelateddiseases AT theofanischatzistamatiou interplaybetweenmesenchymalstromalcellsandimmunesystemclinicalapplicationsinimmunerelateddiseases AT catherinestavropoulosgiokas interplaybetweenmesenchymalstromalcellsandimmunesystemclinicalapplicationsinimmunerelateddiseases
_version_	1718415947145936896

Interplay between mesenchymal stromal cells and immune system: clinical applications in immune-related diseases

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