Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition

Abstract Metabolic syndrome, which increases the risk of obesity and type 2 diabetes has emerged as a significant issue worldwide. Recent studies have highlighted the relationship between metabolic imbalance and neurological pathologies such as memory loss. Glucagon-like peptide 1 (GLP-1) secreted f...

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Autores principales:	Ming Wang, Gwangho Yoon, Juhyun Song, Jihoon Jo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d943b03039be4c6d9379d30b950d4ed8
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spelling	oai:doaj.org-article:d943b03039be4c6d9379d30b950d4ed82021-12-02T15:51:14ZExendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition10.1038/s41598-021-87809-42045-2322https://doaj.org/article/d943b03039be4c6d9379d30b950d4ed82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87809-4https://doaj.org/toc/2045-2322Abstract Metabolic syndrome, which increases the risk of obesity and type 2 diabetes has emerged as a significant issue worldwide. Recent studies have highlighted the relationship between metabolic imbalance and neurological pathologies such as memory loss. Glucagon-like peptide 1 (GLP-1) secreted from gut L-cells and specific brain nuclei plays multiple roles including regulation of insulin sensitivity, inflammation and synaptic plasticity. Although GLP-1 and GLP-1 receptor agonists appear to have neuroprotective function, the specific mechanism of their action in brain remains unclear. We investigated whether exendin-4, as a GLP-1RA, improves cognitive function and brain insulin resistance in metabolic-imbalanced mice fed a high-fat diet. Considering the result of electrophysiological experiments, exendin-4 inhibits the reduction of long term potentiation (LTP) in high fat diet mouse brain. Further, we identified the neuroprotective effect of exendin-4 in primary cultured hippocampal and cortical neurons in in vitro metabolic imbalanced condition. Our results showed the improvement of IRS-1 phosphorylation, neuronal complexity, and the mature of dendritic spine shape by exendin-4 treatment in metabolic imbalanced in vitro condition. Here, we provides significant evidences on the effect of exendin-4 on synaptic plasticity, long-term potentiation, and neural structure. We suggest that GLP-1 is important to treat neuropathology caused by metabolic syndrome.Ming WangGwangho YoonJuhyun SongJihoon JoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ming Wang Gwangho Yoon Juhyun Song Jihoon Jo Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition
description	Abstract Metabolic syndrome, which increases the risk of obesity and type 2 diabetes has emerged as a significant issue worldwide. Recent studies have highlighted the relationship between metabolic imbalance and neurological pathologies such as memory loss. Glucagon-like peptide 1 (GLP-1) secreted from gut L-cells and specific brain nuclei plays multiple roles including regulation of insulin sensitivity, inflammation and synaptic plasticity. Although GLP-1 and GLP-1 receptor agonists appear to have neuroprotective function, the specific mechanism of their action in brain remains unclear. We investigated whether exendin-4, as a GLP-1RA, improves cognitive function and brain insulin resistance in metabolic-imbalanced mice fed a high-fat diet. Considering the result of electrophysiological experiments, exendin-4 inhibits the reduction of long term potentiation (LTP) in high fat diet mouse brain. Further, we identified the neuroprotective effect of exendin-4 in primary cultured hippocampal and cortical neurons in in vitro metabolic imbalanced condition. Our results showed the improvement of IRS-1 phosphorylation, neuronal complexity, and the mature of dendritic spine shape by exendin-4 treatment in metabolic imbalanced in vitro condition. Here, we provides significant evidences on the effect of exendin-4 on synaptic plasticity, long-term potentiation, and neural structure. We suggest that GLP-1 is important to treat neuropathology caused by metabolic syndrome.
format	article
author	Ming Wang Gwangho Yoon Juhyun Song Jihoon Jo
author_facet	Ming Wang Gwangho Yoon Juhyun Song Jihoon Jo
author_sort	Ming Wang
title	Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition
title_short	Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition
title_full	Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition
title_fullStr	Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition
title_full_unstemmed	Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition
title_sort	exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d943b03039be4c6d9379d30b950d4ed8
work_keys_str_mv	AT mingwang exendin4improveslongtermpotentiationandneuronaldendriticgrowthinvivoandinvitroobesitycondition AT gwanghoyoon exendin4improveslongtermpotentiationandneuronaldendriticgrowthinvivoandinvitroobesitycondition AT juhyunsong exendin4improveslongtermpotentiationandneuronaldendriticgrowthinvivoandinvitroobesitycondition AT jihoonjo exendin4improveslongtermpotentiationandneuronaldendriticgrowthinvivoandinvitroobesitycondition
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Exendin-4 improves long-term potentiation and neuronal dendritic growth in vivo and in vitro obesity condition

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