Clinical, laboratory, and radiological characteristics of COVID-19-infected children admitted to pediatric intensive care unit: a single-center experience

Abstract Background During the second wave of COVID-19, there is an increasing incidence of reported cases in children compared to the early wave. Data on the clinical and laboratory characteristics of COVID-19 in children are evolving, and reports on the characteristics and outcomes of severe COVID...

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Autores principales:	Heba Mostafa Ahmed, Rehab Muhammad Abd El Kareem, Faten Mohamed Ali, Ahmed Reda Sayed, Yasmen Awadalh Mohamed
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	COVID-19 Pediatric intensive care unit Multisystem inflammatory syndrome in children Medicine (General) R5-920 Science Q
Acceso en línea:	https://doaj.org/article/d94740aa02d14c5783de15bc0da886ad
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spelling	oai:doaj.org-article:d94740aa02d14c5783de15bc0da886ad2021-11-21T12:28:38ZClinical, laboratory, and radiological characteristics of COVID-19-infected children admitted to pediatric intensive care unit: a single-center experience10.1186/s43088-021-00168-x2314-8543https://doaj.org/article/d94740aa02d14c5783de15bc0da886ad2021-11-01T00:00:00Zhttps://doi.org/10.1186/s43088-021-00168-xhttps://doaj.org/toc/2314-8543Abstract Background During the second wave of COVID-19, there is an increasing incidence of reported cases in children compared to the early wave. Data on the clinical and laboratory characteristics of COVID-19 in children are evolving, and reports on the characteristics and outcomes of severe COVID-19 in children are still under evaluation. We aimed to describe the clinical, laboratory, and radiological characteristics and outcomes of children with COVID-19 infection admitted to the pediatric intensive care unit (PICU). Results The study included 27 children with COVID-19 infection. Fever, respiratory, and gastrointestinal (GIT) symptoms were predominant presenting symptoms in our patients. The median age of our patients was 9 months (2 m–12 years). Comorbidity was reported in 59.3%. The typical laboratory findings were leukocytosis, lymphopenia, elevated C-reactive proteins levels, and elevated d-dimer levels. The most frequent radiological findings were ground-glass opacities in 100% of patients and bilateral findings in 96%, while cardiomegaly was found in 44% of patients. The multisystem inflammatory syndrome was reported in 33% of patients with GIT symptoms were the most frequent presenting symptoms. Myocarditis was reported in 22% of patients. The mortality rate in this cohort was 14.8%. On multivariate analysis, the only predictor of mortality was the development of MIS-C. Conclusions COVID-19 is more severe in children with comorbid conditions. Fever, respiratory and gastrointestinal (GIT) symptoms were predominant presenting symptoms. MIS-C is of increasing concern in children with high mortality rates.Heba Mostafa AhmedRehab Muhammad Abd El KareemFaten Mohamed AliAhmed Reda SayedYasmen Awadalh MohamedSpringerOpenarticleCOVID-19Pediatric intensive care unitMultisystem inflammatory syndrome in childrenMedicine (General)R5-920ScienceQENBeni-Suef University Journal of Basic and Applied Sciences, Vol 10, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Pediatric intensive care unit Multisystem inflammatory syndrome in children Medicine (General) R5-920 Science Q
spellingShingle	COVID-19 Pediatric intensive care unit Multisystem inflammatory syndrome in children Medicine (General) R5-920 Science Q Heba Mostafa Ahmed Rehab Muhammad Abd El Kareem Faten Mohamed Ali Ahmed Reda Sayed Yasmen Awadalh Mohamed Clinical, laboratory, and radiological characteristics of COVID-19-infected children admitted to pediatric intensive care unit: a single-center experience
description	Abstract Background During the second wave of COVID-19, there is an increasing incidence of reported cases in children compared to the early wave. Data on the clinical and laboratory characteristics of COVID-19 in children are evolving, and reports on the characteristics and outcomes of severe COVID-19 in children are still under evaluation. We aimed to describe the clinical, laboratory, and radiological characteristics and outcomes of children with COVID-19 infection admitted to the pediatric intensive care unit (PICU). Results The study included 27 children with COVID-19 infection. Fever, respiratory, and gastrointestinal (GIT) symptoms were predominant presenting symptoms in our patients. The median age of our patients was 9 months (2 m–12 years). Comorbidity was reported in 59.3%. The typical laboratory findings were leukocytosis, lymphopenia, elevated C-reactive proteins levels, and elevated d-dimer levels. The most frequent radiological findings were ground-glass opacities in 100% of patients and bilateral findings in 96%, while cardiomegaly was found in 44% of patients. The multisystem inflammatory syndrome was reported in 33% of patients with GIT symptoms were the most frequent presenting symptoms. Myocarditis was reported in 22% of patients. The mortality rate in this cohort was 14.8%. On multivariate analysis, the only predictor of mortality was the development of MIS-C. Conclusions COVID-19 is more severe in children with comorbid conditions. Fever, respiratory and gastrointestinal (GIT) symptoms were predominant presenting symptoms. MIS-C is of increasing concern in children with high mortality rates.
format	article
author	Heba Mostafa Ahmed Rehab Muhammad Abd El Kareem Faten Mohamed Ali Ahmed Reda Sayed Yasmen Awadalh Mohamed
author_facet	Heba Mostafa Ahmed Rehab Muhammad Abd El Kareem Faten Mohamed Ali Ahmed Reda Sayed Yasmen Awadalh Mohamed
author_sort	Heba Mostafa Ahmed
title	Clinical, laboratory, and radiological characteristics of COVID-19-infected children admitted to pediatric intensive care unit: a single-center experience
title_short	Clinical, laboratory, and radiological characteristics of COVID-19-infected children admitted to pediatric intensive care unit: a single-center experience
title_full	Clinical, laboratory, and radiological characteristics of COVID-19-infected children admitted to pediatric intensive care unit: a single-center experience
title_fullStr	Clinical, laboratory, and radiological characteristics of COVID-19-infected children admitted to pediatric intensive care unit: a single-center experience
title_full_unstemmed	Clinical, laboratory, and radiological characteristics of COVID-19-infected children admitted to pediatric intensive care unit: a single-center experience
title_sort	clinical, laboratory, and radiological characteristics of covid-19-infected children admitted to pediatric intensive care unit: a single-center experience
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/d94740aa02d14c5783de15bc0da886ad
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Clinical, laboratory, and radiological characteristics of COVID-19-infected children admitted to pediatric intensive care unit: a single-center experience

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