Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements

Mobile genetic elements have evolved anti-CRISPR (Acr) proteins to bypass the immunity provided by prokaryotic CRISPR–Cas systems. Here, the authors identify 11 type I Acrs encoded on mobile genetic elements, and show that acr loci neighborhoods can be used to discover inhibitors of other bacterial...

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Autores principales:	Rafael Pinilla-Redondo, Saadlee Shehreen, Nicole D. Marino, Robert D. Fagerlund, Chris M. Brown, Søren J. Sørensen, Peter C. Fineran, Joseph Bondy-Denomy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d9475332a4d84a3d8ba6e1f2654da4ac
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spelling	oai:doaj.org-article:d9475332a4d84a3d8ba6e1f2654da4ac2021-12-02T14:40:41ZDiscovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements10.1038/s41467-020-19415-32041-1723https://doaj.org/article/d9475332a4d84a3d8ba6e1f2654da4ac2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19415-3https://doaj.org/toc/2041-1723Mobile genetic elements have evolved anti-CRISPR (Acr) proteins to bypass the immunity provided by prokaryotic CRISPR–Cas systems. Here, the authors identify 11 type I Acrs encoded on mobile genetic elements, and show that acr loci neighborhoods can be used to discover inhibitors of other bacterial defense systems.Rafael Pinilla-RedondoSaadlee ShehreenNicole D. MarinoRobert D. FagerlundChris M. BrownSøren J. SørensenPeter C. FineranJoseph Bondy-DenomyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rafael Pinilla-Redondo Saadlee Shehreen Nicole D. Marino Robert D. Fagerlund Chris M. Brown Søren J. Sørensen Peter C. Fineran Joseph Bondy-Denomy Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements
description	Mobile genetic elements have evolved anti-CRISPR (Acr) proteins to bypass the immunity provided by prokaryotic CRISPR–Cas systems. Here, the authors identify 11 type I Acrs encoded on mobile genetic elements, and show that acr loci neighborhoods can be used to discover inhibitors of other bacterial defense systems.
format	article
author	Rafael Pinilla-Redondo Saadlee Shehreen Nicole D. Marino Robert D. Fagerlund Chris M. Brown Søren J. Sørensen Peter C. Fineran Joseph Bondy-Denomy
author_facet	Rafael Pinilla-Redondo Saadlee Shehreen Nicole D. Marino Robert D. Fagerlund Chris M. Brown Søren J. Sørensen Peter C. Fineran Joseph Bondy-Denomy
author_sort	Rafael Pinilla-Redondo
title	Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements
title_short	Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements
title_full	Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements
title_fullStr	Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements
title_full_unstemmed	Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements
title_sort	discovery of multiple anti-crisprs highlights anti-defense gene clustering in mobile genetic elements
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d9475332a4d84a3d8ba6e1f2654da4ac
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Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements

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