Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups

Cellular associations in the bone microenvironment are involved in modulating the balance between bone remodeling and resorption, which is necessary for maintaining a normal bone morphology. Macrophages and osteoclasts are both vital components of the bone marrow. Macrophages can interact with osteo...

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Autores principales:	Yang Sun, Jiangbi Li, Xiaoping Xie, Feng Gu, Zhenjiang Sui, Ke Zhang, Tiecheng Yu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	macrophages osteoclasts associations origin polarization cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d94827f826ce4ca2ae729e02a4e6c35e
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spelling	oai:doaj.org-article:d94827f826ce4ca2ae729e02a4e6c35e2021-12-02T00:21:23ZMacrophage-Osteoclast Associations: Origin, Polarization, and Subgroups1664-322410.3389/fimmu.2021.778078https://doaj.org/article/d94827f826ce4ca2ae729e02a4e6c35e2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.778078/fullhttps://doaj.org/toc/1664-3224Cellular associations in the bone microenvironment are involved in modulating the balance between bone remodeling and resorption, which is necessary for maintaining a normal bone morphology. Macrophages and osteoclasts are both vital components of the bone marrow. Macrophages can interact with osteoclasts and regulate bone metabolism by secreting a variety of cytokines, which make a significant contribution to the associations. Although, recent studies have fully explored either macrophages or osteoclasts, indicating the significance of these two types of cells. However, it is of high importance to report the latest discoveries on the relationships between these two myeloid-derived cells in the field of osteoimmunology. Therefore, this paper reviews this topic from three novel aspects of the origin, polarization, and subgroups based on the previous work, to provide a reference for future research and treatment of bone-related diseases.Yang SunJiangbi LiXiaoping XieFeng GuZhenjiang SuiKe ZhangTiecheng YuFrontiers Media S.A.articlemacrophagesosteoclastsassociationsoriginpolarizationcytokinesImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	macrophages osteoclasts associations origin polarization cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	macrophages osteoclasts associations origin polarization cytokines Immunologic diseases. Allergy RC581-607 Yang Sun Jiangbi Li Xiaoping Xie Feng Gu Zhenjiang Sui Ke Zhang Tiecheng Yu Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups
description	Cellular associations in the bone microenvironment are involved in modulating the balance between bone remodeling and resorption, which is necessary for maintaining a normal bone morphology. Macrophages and osteoclasts are both vital components of the bone marrow. Macrophages can interact with osteoclasts and regulate bone metabolism by secreting a variety of cytokines, which make a significant contribution to the associations. Although, recent studies have fully explored either macrophages or osteoclasts, indicating the significance of these two types of cells. However, it is of high importance to report the latest discoveries on the relationships between these two myeloid-derived cells in the field of osteoimmunology. Therefore, this paper reviews this topic from three novel aspects of the origin, polarization, and subgroups based on the previous work, to provide a reference for future research and treatment of bone-related diseases.
format	article
author	Yang Sun Jiangbi Li Xiaoping Xie Feng Gu Zhenjiang Sui Ke Zhang Tiecheng Yu
author_facet	Yang Sun Jiangbi Li Xiaoping Xie Feng Gu Zhenjiang Sui Ke Zhang Tiecheng Yu
author_sort	Yang Sun
title	Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups
title_short	Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups
title_full	Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups
title_fullStr	Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups
title_full_unstemmed	Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups
title_sort	macrophage-osteoclast associations: origin, polarization, and subgroups
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d94827f826ce4ca2ae729e02a4e6c35e
work_keys_str_mv	AT yangsun macrophageosteoclastassociationsoriginpolarizationandsubgroups AT jiangbili macrophageosteoclastassociationsoriginpolarizationandsubgroups AT xiaopingxie macrophageosteoclastassociationsoriginpolarizationandsubgroups AT fenggu macrophageosteoclastassociationsoriginpolarizationandsubgroups AT zhenjiangsui macrophageosteoclastassociationsoriginpolarizationandsubgroups AT kezhang macrophageosteoclastassociationsoriginpolarizationandsubgroups AT tiechengyu macrophageosteoclastassociationsoriginpolarizationandsubgroups
_version_	1718403833627934720

Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups

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