Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy

Pure drug-assembled nanomedicines (PDANs) are currently under intensive investigation as promising nanoplatforms for cancer therapy. However, poor colloidal stability and less tumor-homing ability remain critical unresolved problems that impede their clinical translation. Herein, we report a core-ma...

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Autores principales:	Shenwu Zhang, Yuequan Wang, Zhiqiang Kong, Xuanbo Zhang, Bingjun Sun, Han Yu, Qin Chen, Cong Luo, Jin Sun, Zhonggui He
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Pure drug-assembled nanomedicines Pure photosensitizer Pyropheophorbide a Core-matched Self-assembly Nanoassembly Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d94be8487dc14dd48106e3a8f0d08b7e
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spelling	oai:doaj.org-article:d94be8487dc14dd48106e3a8f0d08b7e2021-12-02T05:01:22ZPure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy2211-383510.1016/j.apsb.2021.04.005https://doaj.org/article/d94be8487dc14dd48106e3a8f0d08b7e2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211383521001325https://doaj.org/toc/2211-3835Pure drug-assembled nanomedicines (PDANs) are currently under intensive investigation as promising nanoplatforms for cancer therapy. However, poor colloidal stability and less tumor-homing ability remain critical unresolved problems that impede their clinical translation. Herein, we report a core-matched nanoassembly of pyropheophorbide a (PPa) for photodynamic therapy (PDT). Pure PPa molecules are found to self-assemble into nanoparticles (NPs), and an amphiphilic PEG polymer (PPa-PEG2K) is utilized to achieve core-matched PEGylating modification via the π‒π stacking effect and hydrophobic interaction between the PPa core and the PPa-PEG2K shell. Compared to PCL-PEG2K with similar molecular weight, PPa-PEG2K significantly increases the stability, prolongs the systemic circulation and improves the tumor-homing ability and ROS generation efficiency of PPa-nanoassembly. As a result, PPa/PPa-PEG2K NPs exert potent antitumor activity in a 4T1 breast tumor-bearing BALB/c mouse xenograft model. Together, such a core-matched nanoassembly of pure photosensitizer provides a new strategy for the development of imaging-guided theragnostic nanomedicines.Shenwu ZhangYuequan WangZhiqiang KongXuanbo ZhangBingjun SunHan YuQin ChenCong LuoJin SunZhonggui HeElsevierarticlePure drug-assembled nanomedicinesPure photosensitizerPyropheophorbide aCore-matchedSelf-assemblyNanoassemblyTherapeutics. PharmacologyRM1-950ENActa Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3636-3647 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pure drug-assembled nanomedicines Pure photosensitizer Pyropheophorbide a Core-matched Self-assembly Nanoassembly Therapeutics. Pharmacology RM1-950
spellingShingle	Pure drug-assembled nanomedicines Pure photosensitizer Pyropheophorbide a Core-matched Self-assembly Nanoassembly Therapeutics. Pharmacology RM1-950 Shenwu Zhang Yuequan Wang Zhiqiang Kong Xuanbo Zhang Bingjun Sun Han Yu Qin Chen Cong Luo Jin Sun Zhonggui He Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy
description	Pure drug-assembled nanomedicines (PDANs) are currently under intensive investigation as promising nanoplatforms for cancer therapy. However, poor colloidal stability and less tumor-homing ability remain critical unresolved problems that impede their clinical translation. Herein, we report a core-matched nanoassembly of pyropheophorbide a (PPa) for photodynamic therapy (PDT). Pure PPa molecules are found to self-assemble into nanoparticles (NPs), and an amphiphilic PEG polymer (PPa-PEG2K) is utilized to achieve core-matched PEGylating modification via the π‒π stacking effect and hydrophobic interaction between the PPa core and the PPa-PEG2K shell. Compared to PCL-PEG2K with similar molecular weight, PPa-PEG2K significantly increases the stability, prolongs the systemic circulation and improves the tumor-homing ability and ROS generation efficiency of PPa-nanoassembly. As a result, PPa/PPa-PEG2K NPs exert potent antitumor activity in a 4T1 breast tumor-bearing BALB/c mouse xenograft model. Together, such a core-matched nanoassembly of pure photosensitizer provides a new strategy for the development of imaging-guided theragnostic nanomedicines.
format	article
author	Shenwu Zhang Yuequan Wang Zhiqiang Kong Xuanbo Zhang Bingjun Sun Han Yu Qin Chen Cong Luo Jin Sun Zhonggui He
author_facet	Shenwu Zhang Yuequan Wang Zhiqiang Kong Xuanbo Zhang Bingjun Sun Han Yu Qin Chen Cong Luo Jin Sun Zhonggui He
author_sort	Shenwu Zhang
title	Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy
title_short	Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy
title_full	Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy
title_fullStr	Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy
title_full_unstemmed	Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy
title_sort	pure photosensitizer-driven nanoassembly with core-matched pegylation for imaging-guided photodynamic therapy
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d94be8487dc14dd48106e3a8f0d08b7e
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Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy

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