Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity

Dependency of diverse cancers on specific BCL-2 family members and their combinations is unknown. Here they perform drug screening and find most cell lines to be dependent on at least one combination of BCL-2 family members, and using a CRISPR screen find BCL-w and BFL-1 to mediate resistance to BH3...

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Main Authors:	Ryan S. Soderquist, Lorin Crawford, Esther Liu, Min Lu, Anika Agarwal, Grace R. Anderson, Kevin H. Lin, Peter S. Winter, Merve Cakir, Kris C. Wood
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/d950f5d4286b4fd19e6d199b06c153c5
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spelling	oai:doaj.org-article:d950f5d4286b4fd19e6d199b06c153c52021-12-02T14:40:10ZSystematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity10.1038/s41467-018-05815-z2041-1723https://doaj.org/article/d950f5d4286b4fd19e6d199b06c153c52018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05815-zhttps://doaj.org/toc/2041-1723Dependency of diverse cancers on specific BCL-2 family members and their combinations is unknown. Here they perform drug screening and find most cell lines to be dependent on at least one combination of BCL-2 family members, and using a CRISPR screen find BCL-w and BFL-1 to mediate resistance to BH3 mimeticsRyan S. SoderquistLorin CrawfordEsther LiuMin LuAnika AgarwalGrace R. AndersonKevin H. LinPeter S. WinterMerve CakirKris C. WoodNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryan S. Soderquist Lorin Crawford Esther Liu Min Lu Anika Agarwal Grace R. Anderson Kevin H. Lin Peter S. Winter Merve Cakir Kris C. Wood Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
description	Dependency of diverse cancers on specific BCL-2 family members and their combinations is unknown. Here they perform drug screening and find most cell lines to be dependent on at least one combination of BCL-2 family members, and using a CRISPR screen find BCL-w and BFL-1 to mediate resistance to BH3 mimetics
format	article
author	Ryan S. Soderquist Lorin Crawford Esther Liu Min Lu Anika Agarwal Grace R. Anderson Kevin H. Lin Peter S. Winter Merve Cakir Kris C. Wood
author_facet	Ryan S. Soderquist Lorin Crawford Esther Liu Min Lu Anika Agarwal Grace R. Anderson Kevin H. Lin Peter S. Winter Merve Cakir Kris C. Wood
author_sort	Ryan S. Soderquist
title	Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
title_short	Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
title_full	Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
title_fullStr	Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
title_full_unstemmed	Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
title_sort	systematic mapping of bcl-2 gene dependencies in cancer reveals molecular determinants of bh3 mimetic sensitivity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d950f5d4286b4fd19e6d199b06c153c5
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Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity

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