Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates

T cell tolerance is established in the thymus via interactions with medullary thymic epithelial cells (mTEC) expressing tissue-restricted self antigens. Here, the authors suggest, using new transgenic mouse lines and single cell transcriptome analyses, that specific mTEC subsets are associated with...

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Autores principales:	Marie-Ève Lebel, Marie Coutelier, Maria Galipeau, Claudia L. Kleinman, James J. Moon, Heather J. Melichar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d95861ab2e314e62a5e742bbc1326592
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spelling	oai:doaj.org-article:d95861ab2e314e62a5e742bbc13265922021-12-02T16:26:32ZDifferential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates10.1038/s41467-020-17544-32041-1723https://doaj.org/article/d95861ab2e314e62a5e742bbc13265922020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17544-3https://doaj.org/toc/2041-1723T cell tolerance is established in the thymus via interactions with medullary thymic epithelial cells (mTEC) expressing tissue-restricted self antigens. Here, the authors suggest, using new transgenic mouse lines and single cell transcriptome analyses, that specific mTEC subsets are associated with distinct T cell fates.Marie-Ève LebelMarie CoutelierMaria GalipeauClaudia L. KleinmanJames J. MoonHeather J. MelicharNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marie-Ève Lebel Marie Coutelier Maria Galipeau Claudia L. Kleinman James J. Moon Heather J. Melichar Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates
description	T cell tolerance is established in the thymus via interactions with medullary thymic epithelial cells (mTEC) expressing tissue-restricted self antigens. Here, the authors suggest, using new transgenic mouse lines and single cell transcriptome analyses, that specific mTEC subsets are associated with distinct T cell fates.
format	article
author	Marie-Ève Lebel Marie Coutelier Maria Galipeau Claudia L. Kleinman James J. Moon Heather J. Melichar
author_facet	Marie-Ève Lebel Marie Coutelier Maria Galipeau Claudia L. Kleinman James J. Moon Heather J. Melichar
author_sort	Marie-Ève Lebel
title	Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates
title_short	Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates
title_full	Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates
title_fullStr	Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates
title_full_unstemmed	Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates
title_sort	differential expression of tissue-restricted antigens among mtec is associated with distinct autoreactive t cell fates
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d95861ab2e314e62a5e742bbc1326592
work_keys_str_mv	AT marieevelebel differentialexpressionoftissuerestrictedantigensamongmtecisassociatedwithdistinctautoreactivetcellfates AT mariecoutelier differentialexpressionoftissuerestrictedantigensamongmtecisassociatedwithdistinctautoreactivetcellfates AT mariagalipeau differentialexpressionoftissuerestrictedantigensamongmtecisassociatedwithdistinctautoreactivetcellfates AT claudialkleinman differentialexpressionoftissuerestrictedantigensamongmtecisassociatedwithdistinctautoreactivetcellfates AT jamesjmoon differentialexpressionoftissuerestrictedantigensamongmtecisassociatedwithdistinctautoreactivetcellfates AT heatherjmelichar differentialexpressionoftissuerestrictedantigensamongmtecisassociatedwithdistinctautoreactivetcellfates
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Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates

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