Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates

T cell tolerance is established in the thymus via interactions with medullary thymic epithelial cells (mTEC) expressing tissue-restricted self antigens. Here, the authors suggest, using new transgenic mouse lines and single cell transcriptome analyses, that specific mTEC subsets are associated with...

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Autores principales: Marie-Ève Lebel, Marie Coutelier, Maria Galipeau, Claudia L. Kleinman, James J. Moon, Heather J. Melichar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d95861ab2e314e62a5e742bbc1326592
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