Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants

Abstract Environmental pollutants as non-heritable factors are now recognized as triggers for multiple human inflammatory diseases involving T cells. We postulated that lipid antigen presentation mediated by cluster of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophil...

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Autores principales:	Manju Sharma, Xiang Zhang, Shuangmin Zhang, Liang Niu, Shuk-mei Ho, Aimin Chen, Shouxiong Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d95f24983700435e83cca1b3572eeaa3
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spelling	oai:doaj.org-article:d95f24983700435e83cca1b3572eeaa32021-12-02T15:05:19ZInhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants10.1038/s41598-017-02229-72045-2322https://doaj.org/article/d95f24983700435e83cca1b3572eeaa32017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02229-7https://doaj.org/toc/2045-2322Abstract Environmental pollutants as non-heritable factors are now recognized as triggers for multiple human inflammatory diseases involving T cells. We postulated that lipid antigen presentation mediated by cluster of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophilic environmental pollutants. To test this notion, we determined whether the common lipophilic pollutants benzo[a]pyrene and diesel exhaust particles impact on the activation of lipid-specific T cells. Our results demonstrated that the expression of CD1a and CD1d proteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a]pyrene even at the low concentrations detectable in exposed human populations. Similarly, diesel exhaust particles showed a marginal inhibitory effect. Using transcriptomic profiling, we discovered that the gene expression for regulating endocytic and lipid metabolic pathways was perturbed by benzo[a]pyrene. Imaging flow cytometry also showed that CD1a and CD1d proteins were retained in early and late endosomal compartments, respectively, supporting an impaired endocytic lipid antigen presentation for T cell activation upon benzo[a]pyrene exposure. This work conceptually demonstrates that lipid antigen presentation for T cell activation is inhibited by lipophilic pollutants through profound interference with gene expression and endocytic function, likely further disrupting regulatory cytokine secretion and ultimately exacerbating inflammatory diseases.Manju SharmaXiang ZhangShuangmin ZhangLiang NiuShuk-mei HoAimin ChenShouxiong HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manju Sharma Xiang Zhang Shuangmin Zhang Liang Niu Shuk-mei Ho Aimin Chen Shouxiong Huang Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants
description	Abstract Environmental pollutants as non-heritable factors are now recognized as triggers for multiple human inflammatory diseases involving T cells. We postulated that lipid antigen presentation mediated by cluster of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophilic environmental pollutants. To test this notion, we determined whether the common lipophilic pollutants benzo[a]pyrene and diesel exhaust particles impact on the activation of lipid-specific T cells. Our results demonstrated that the expression of CD1a and CD1d proteins, and the activation of CD1a- and CD1d-restricted T cells were sensitively inhibited by benzo[a]pyrene even at the low concentrations detectable in exposed human populations. Similarly, diesel exhaust particles showed a marginal inhibitory effect. Using transcriptomic profiling, we discovered that the gene expression for regulating endocytic and lipid metabolic pathways was perturbed by benzo[a]pyrene. Imaging flow cytometry also showed that CD1a and CD1d proteins were retained in early and late endosomal compartments, respectively, supporting an impaired endocytic lipid antigen presentation for T cell activation upon benzo[a]pyrene exposure. This work conceptually demonstrates that lipid antigen presentation for T cell activation is inhibited by lipophilic pollutants through profound interference with gene expression and endocytic function, likely further disrupting regulatory cytokine secretion and ultimately exacerbating inflammatory diseases.
format	article
author	Manju Sharma Xiang Zhang Shuangmin Zhang Liang Niu Shuk-mei Ho Aimin Chen Shouxiong Huang
author_facet	Manju Sharma Xiang Zhang Shuangmin Zhang Liang Niu Shuk-mei Ho Aimin Chen Shouxiong Huang
author_sort	Manju Sharma
title	Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants
title_short	Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants
title_full	Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants
title_fullStr	Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants
title_full_unstemmed	Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants
title_sort	inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d95f24983700435e83cca1b3572eeaa3
work_keys_str_mv	AT manjusharma inhibitionofendocyticlipidantigenpresentationbycommonlipophilicenvironmentalpollutants AT xiangzhang inhibitionofendocyticlipidantigenpresentationbycommonlipophilicenvironmentalpollutants AT shuangminzhang inhibitionofendocyticlipidantigenpresentationbycommonlipophilicenvironmentalpollutants AT liangniu inhibitionofendocyticlipidantigenpresentationbycommonlipophilicenvironmentalpollutants AT shukmeiho inhibitionofendocyticlipidantigenpresentationbycommonlipophilicenvironmentalpollutants AT aiminchen inhibitionofendocyticlipidantigenpresentationbycommonlipophilicenvironmentalpollutants AT shouxionghuang inhibitionofendocyticlipidantigenpresentationbycommonlipophilicenvironmentalpollutants
_version_	1718388924883140608

Inhibition of endocytic lipid antigen presentation by common lipophilic environmental pollutants

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