A ‘dynamic adder model’ for cell size homeostasis in Dictyostelium cells

Abstract After a cell divides into two daughter cells, the total cell surface area of the daughter cells should increase to the original size to maintain cell size homeostasis in a single cell cycle. Previously, three models have been proposed to explain the regulation of cell size homeostasis: size...

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Autores principales:	Masahito Tanaka, Toshiko Kitanishi-Yumura, Shigehiko Yumura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d961b13b39cf46c5aa988d7e14694eca
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spelling	oai:doaj.org-article:d961b13b39cf46c5aa988d7e14694eca2021-12-02T16:32:13ZA ‘dynamic adder model’ for cell size homeostasis in Dictyostelium cells10.1038/s41598-021-92700-32045-2322https://doaj.org/article/d961b13b39cf46c5aa988d7e14694eca2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92700-3https://doaj.org/toc/2045-2322Abstract After a cell divides into two daughter cells, the total cell surface area of the daughter cells should increase to the original size to maintain cell size homeostasis in a single cell cycle. Previously, three models have been proposed to explain the regulation of cell size homeostasis: sizer, timer, and adder models. Here, we precisely measured the total cell surface area of Dictyostelium cells in a whole cell cycle by using the agar-overlay method, which eliminated the influence of surface membrane reservoirs, such as microvilli and membrane wrinkles. The total cell surface area exponentially increased during interphase, slightly decreased at metaphase, and then increased by approximately 20% during cytokinesis. From the analysis of the added surface area, we concluded that the cell size was regulated by the adder or near-adder model in interphase. This adder model is not caused by a simple cell membrane addition, but is more dynamic due to the rapid cell membrane turnover. We propose a ‘dynamic adder model’ to explain cell size homeostasis in interphase.Masahito TanakaToshiko Kitanishi-YumuraShigehiko YumuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masahito Tanaka Toshiko Kitanishi-Yumura Shigehiko Yumura A ‘dynamic adder model’ for cell size homeostasis in Dictyostelium cells
description	Abstract After a cell divides into two daughter cells, the total cell surface area of the daughter cells should increase to the original size to maintain cell size homeostasis in a single cell cycle. Previously, three models have been proposed to explain the regulation of cell size homeostasis: sizer, timer, and adder models. Here, we precisely measured the total cell surface area of Dictyostelium cells in a whole cell cycle by using the agar-overlay method, which eliminated the influence of surface membrane reservoirs, such as microvilli and membrane wrinkles. The total cell surface area exponentially increased during interphase, slightly decreased at metaphase, and then increased by approximately 20% during cytokinesis. From the analysis of the added surface area, we concluded that the cell size was regulated by the adder or near-adder model in interphase. This adder model is not caused by a simple cell membrane addition, but is more dynamic due to the rapid cell membrane turnover. We propose a ‘dynamic adder model’ to explain cell size homeostasis in interphase.
format	article
author	Masahito Tanaka Toshiko Kitanishi-Yumura Shigehiko Yumura
author_facet	Masahito Tanaka Toshiko Kitanishi-Yumura Shigehiko Yumura
author_sort	Masahito Tanaka
title	A ‘dynamic adder model’ for cell size homeostasis in Dictyostelium cells
title_short	A ‘dynamic adder model’ for cell size homeostasis in Dictyostelium cells
title_full	A ‘dynamic adder model’ for cell size homeostasis in Dictyostelium cells
title_fullStr	A ‘dynamic adder model’ for cell size homeostasis in Dictyostelium cells
title_full_unstemmed	A ‘dynamic adder model’ for cell size homeostasis in Dictyostelium cells
title_sort	‘dynamic adder model’ for cell size homeostasis in dictyostelium cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d961b13b39cf46c5aa988d7e14694eca
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A ‘dynamic adder model’ for cell size homeostasis in Dictyostelium cells

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