Structural connectivity-based segmentation of the human entorhinal cortex

The medial (MEC) and lateral entorhinal cortex (LEC), widely studied in rodents, are well defined and characterized. In humans, however, the exact locations of their homologues remain uncertain. Previous functional magnetic resonance imaging (fMRI) studies have subdivided the human EC into posterome...

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Autores principales:	Ingrid Framås Syversen, Menno P. Witter, Asgeir Kobro-Flatmoen, Pål Erik Goa, Tobias Navarro Schröder, Christian F. Doeller
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Magnetic resonance imaging Diffusion tensor imaging Structural connectivity Medial entorhinal cortex Lateral entorhinal cortex Segmentation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/d962b4dc7ae34d87be57f139cc000a29
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spelling	oai:doaj.org-article:d962b4dc7ae34d87be57f139cc000a292021-11-18T04:44:59ZStructural connectivity-based segmentation of the human entorhinal cortex1095-957210.1016/j.neuroimage.2021.118723https://doaj.org/article/d962b4dc7ae34d87be57f139cc000a292021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921009952https://doaj.org/toc/1095-9572The medial (MEC) and lateral entorhinal cortex (LEC), widely studied in rodents, are well defined and characterized. In humans, however, the exact locations of their homologues remain uncertain. Previous functional magnetic resonance imaging (fMRI) studies have subdivided the human EC into posteromedial (pmEC) and anterolateral (alEC) parts, but uncertainty remains about the choice of imaging modality and seed regions, in particular in light of a substantial revision of the classical model of EC connectivity based on novel insights from rodent anatomy. Here, we used structural, not functional imaging, namely diffusion tensor imaging (DTI) and probabilistic tractography to segment the human EC based on differential connectivity to other brain regions known to project selectively to MEC or LEC. We defined MEC as more strongly connected with presubiculum and retrosplenial cortex (RSC), and LEC as more strongly connected with distal CA1 and proximal subiculum (dCA1pSub) and lateral orbitofrontal cortex (OFC). Although our DTI segmentation had a larger medial-lateral component than in the previous fMRI studies, our results show that the human MEC and LEC homologues have a border oriented both towards the posterior-anterior and medial-lateral axes, supporting the differentiation between pmEC and alEC.Ingrid Framås SyversenMenno P. WitterAsgeir Kobro-FlatmoenPål Erik GoaTobias Navarro SchröderChristian F. DoellerElsevierarticleMagnetic resonance imagingDiffusion tensor imagingStructural connectivityMedial entorhinal cortexLateral entorhinal cortexSegmentationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118723- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Magnetic resonance imaging Diffusion tensor imaging Structural connectivity Medial entorhinal cortex Lateral entorhinal cortex Segmentation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Magnetic resonance imaging Diffusion tensor imaging Structural connectivity Medial entorhinal cortex Lateral entorhinal cortex Segmentation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Ingrid Framås Syversen Menno P. Witter Asgeir Kobro-Flatmoen Pål Erik Goa Tobias Navarro Schröder Christian F. Doeller Structural connectivity-based segmentation of the human entorhinal cortex
description	The medial (MEC) and lateral entorhinal cortex (LEC), widely studied in rodents, are well defined and characterized. In humans, however, the exact locations of their homologues remain uncertain. Previous functional magnetic resonance imaging (fMRI) studies have subdivided the human EC into posteromedial (pmEC) and anterolateral (alEC) parts, but uncertainty remains about the choice of imaging modality and seed regions, in particular in light of a substantial revision of the classical model of EC connectivity based on novel insights from rodent anatomy. Here, we used structural, not functional imaging, namely diffusion tensor imaging (DTI) and probabilistic tractography to segment the human EC based on differential connectivity to other brain regions known to project selectively to MEC or LEC. We defined MEC as more strongly connected with presubiculum and retrosplenial cortex (RSC), and LEC as more strongly connected with distal CA1 and proximal subiculum (dCA1pSub) and lateral orbitofrontal cortex (OFC). Although our DTI segmentation had a larger medial-lateral component than in the previous fMRI studies, our results show that the human MEC and LEC homologues have a border oriented both towards the posterior-anterior and medial-lateral axes, supporting the differentiation between pmEC and alEC.
format	article
author	Ingrid Framås Syversen Menno P. Witter Asgeir Kobro-Flatmoen Pål Erik Goa Tobias Navarro Schröder Christian F. Doeller
author_facet	Ingrid Framås Syversen Menno P. Witter Asgeir Kobro-Flatmoen Pål Erik Goa Tobias Navarro Schröder Christian F. Doeller
author_sort	Ingrid Framås Syversen
title	Structural connectivity-based segmentation of the human entorhinal cortex
title_short	Structural connectivity-based segmentation of the human entorhinal cortex
title_full	Structural connectivity-based segmentation of the human entorhinal cortex
title_fullStr	Structural connectivity-based segmentation of the human entorhinal cortex
title_full_unstemmed	Structural connectivity-based segmentation of the human entorhinal cortex
title_sort	structural connectivity-based segmentation of the human entorhinal cortex
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d962b4dc7ae34d87be57f139cc000a29
work_keys_str_mv	AT ingridframassyversen structuralconnectivitybasedsegmentationofthehumanentorhinalcortex AT mennopwitter structuralconnectivitybasedsegmentationofthehumanentorhinalcortex AT asgeirkobroflatmoen structuralconnectivitybasedsegmentationofthehumanentorhinalcortex AT palerikgoa structuralconnectivitybasedsegmentationofthehumanentorhinalcortex AT tobiasnavarroschroder structuralconnectivitybasedsegmentationofthehumanentorhinalcortex AT christianfdoeller structuralconnectivitybasedsegmentationofthehumanentorhinalcortex
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Structural connectivity-based segmentation of the human entorhinal cortex

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