Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications

Nanocellulose, a biopolymer, has received wide attention from researchers owing to its superior physicochemical properties, such as high mechanical strength, low density, biodegradability, and biocompatibility. Nanocellulose can be extracted from wide range of sources, including plants, bacteria, an...

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Autores principales:	Tejal V. Patil, Dinesh K. Patel, Sayan Deb Dutta, Keya Ganguly, Tuhin Subhra Santra, Ki-Taek Lim
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Nanocellulose Chemical functionalization Drug delivery Protein delivery Plasmid delivery Tissue engineering Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d964b24a4030414e928943bc00e23687
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id	oai:doaj.org-article:d964b24a4030414e928943bc00e23687
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spelling	oai:doaj.org-article:d964b24a4030414e928943bc00e236872021-11-10T04:30:29ZNanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications2452-199X10.1016/j.bioactmat.2021.07.006https://doaj.org/article/d964b24a4030414e928943bc00e236872022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X2100339Xhttps://doaj.org/toc/2452-199XNanocellulose, a biopolymer, has received wide attention from researchers owing to its superior physicochemical properties, such as high mechanical strength, low density, biodegradability, and biocompatibility. Nanocellulose can be extracted from wide range of sources, including plants, bacteria, and algae. Depending on the extraction process and dimensions (diameter and length), they are categorized into three main types: cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial nanocellulose (BNC). CNCs are a highly crystalline and needle-like structure, whereas CNFs have both amorphous and crystalline regions in their network. BNC is the purest form of nanocellulose. The nanocellulose properties can be tuned by chemical functionalization, which increases its applicability in biomedical applications. This review highlights the fabrication of different surface-modified nanocellulose to deliver active molecules, such as drugs, proteins, and plasmids. Nanocellulose-mediated delivery of active molecules is profoundly affected by its topographical structure and the interaction between the loaded molecules and nanocellulose. The applications of nanocellulose and its composites in tissue engineering have been discussed. Finally, the review is concluded with further opportunities and challenges in nanocellulose-mediated delivery of active molecules.Tejal V. PatilDinesh K. PatelSayan Deb DuttaKeya GangulyTuhin Subhra SantraKi-Taek LimKeAi Communications Co., Ltd.articleNanocelluloseChemical functionalizationDrug deliveryProtein deliveryPlasmid deliveryTissue engineeringMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 9, Iss , Pp 566-589 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanocellulose Chemical functionalization Drug delivery Protein delivery Plasmid delivery Tissue engineering Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Nanocellulose Chemical functionalization Drug delivery Protein delivery Plasmid delivery Tissue engineering Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Tejal V. Patil Dinesh K. Patel Sayan Deb Dutta Keya Ganguly Tuhin Subhra Santra Ki-Taek Lim Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications
description	Nanocellulose, a biopolymer, has received wide attention from researchers owing to its superior physicochemical properties, such as high mechanical strength, low density, biodegradability, and biocompatibility. Nanocellulose can be extracted from wide range of sources, including plants, bacteria, and algae. Depending on the extraction process and dimensions (diameter and length), they are categorized into three main types: cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial nanocellulose (BNC). CNCs are a highly crystalline and needle-like structure, whereas CNFs have both amorphous and crystalline regions in their network. BNC is the purest form of nanocellulose. The nanocellulose properties can be tuned by chemical functionalization, which increases its applicability in biomedical applications. This review highlights the fabrication of different surface-modified nanocellulose to deliver active molecules, such as drugs, proteins, and plasmids. Nanocellulose-mediated delivery of active molecules is profoundly affected by its topographical structure and the interaction between the loaded molecules and nanocellulose. The applications of nanocellulose and its composites in tissue engineering have been discussed. Finally, the review is concluded with further opportunities and challenges in nanocellulose-mediated delivery of active molecules.
format	article
author	Tejal V. Patil Dinesh K. Patel Sayan Deb Dutta Keya Ganguly Tuhin Subhra Santra Ki-Taek Lim
author_facet	Tejal V. Patil Dinesh K. Patel Sayan Deb Dutta Keya Ganguly Tuhin Subhra Santra Ki-Taek Lim
author_sort	Tejal V. Patil
title	Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications
title_short	Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications
title_full	Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications
title_fullStr	Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications
title_full_unstemmed	Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications
title_sort	nanocellulose, a versatile platform: from the delivery of active molecules to tissue engineering applications
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/d964b24a4030414e928943bc00e23687
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Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications

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