Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress

Biofilm formation: Architecture and antibiotics Studying how the architecture of bacterial biofilms can change on exposure to antibiotics could help tackle persistent clinical infections. Enterococcus faecalis is one of the most prevalent bacteria involved in healthcare situations. Its resistance to...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jennifer L. Dale, Jennifer L. Nilson, Aaron M. T. Barnes, Gary M. Dunny
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Acceso en línea:https://doaj.org/article/d966cb626f414f7188a6d59db0172cec
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:d966cb626f414f7188a6d59db0172cec
record_format dspace
spelling oai:doaj.org-article:d966cb626f414f7188a6d59db0172cec2021-12-02T11:42:16ZRestructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress10.1038/s41522-017-0023-42055-5008https://doaj.org/article/d966cb626f414f7188a6d59db0172cec2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41522-017-0023-4https://doaj.org/toc/2055-5008Biofilm formation: Architecture and antibiotics Studying how the architecture of bacterial biofilms can change on exposure to antibiotics could help tackle persistent clinical infections. Enterococcus faecalis is one of the most prevalent bacteria involved in healthcare situations. Its resistance to antibiotics is elevated by the formation of biofilms. Gary Dunny and colleagues at the University of Minnesota, USA studied genetic factors related to the response of E. faecalis biofilms to antibiotics. They identified mutations that caused the bacterial cells to produce structurally altered biofilms and found that similar structural alterations were induced in biofilms made by normal cells in the presence of antibiotics. The altered architecture can make the biofilms less stable and therefore more easily disrupted by treatments. Learning more about the mechanisms underlying these structural changes in biofilms might lead to new options in treating antibiotic resistant infections.Jennifer L. DaleJennifer L. NilsonAaron M. T. BarnesGary M. DunnyNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 3, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Microbial ecology
QR100-130
spellingShingle Microbial ecology
QR100-130
Jennifer L. Dale
Jennifer L. Nilson
Aaron M. T. Barnes
Gary M. Dunny
Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
description Biofilm formation: Architecture and antibiotics Studying how the architecture of bacterial biofilms can change on exposure to antibiotics could help tackle persistent clinical infections. Enterococcus faecalis is one of the most prevalent bacteria involved in healthcare situations. Its resistance to antibiotics is elevated by the formation of biofilms. Gary Dunny and colleagues at the University of Minnesota, USA studied genetic factors related to the response of E. faecalis biofilms to antibiotics. They identified mutations that caused the bacterial cells to produce structurally altered biofilms and found that similar structural alterations were induced in biofilms made by normal cells in the presence of antibiotics. The altered architecture can make the biofilms less stable and therefore more easily disrupted by treatments. Learning more about the mechanisms underlying these structural changes in biofilms might lead to new options in treating antibiotic resistant infections.
format article
author Jennifer L. Dale
Jennifer L. Nilson
Aaron M. T. Barnes
Gary M. Dunny
author_facet Jennifer L. Dale
Jennifer L. Nilson
Aaron M. T. Barnes
Gary M. Dunny
author_sort Jennifer L. Dale
title Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
title_short Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
title_full Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
title_fullStr Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
title_full_unstemmed Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
title_sort restructuring of enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/d966cb626f414f7188a6d59db0172cec
work_keys_str_mv AT jenniferldale restructuringofenterococcusfaecalisbiofilmarchitectureinresponsetoantibioticinducedstress
AT jenniferlnilson restructuringofenterococcusfaecalisbiofilmarchitectureinresponsetoantibioticinducedstress
AT aaronmtbarnes restructuringofenterococcusfaecalisbiofilmarchitectureinresponsetoantibioticinducedstress
AT garymdunny restructuringofenterococcusfaecalisbiofilmarchitectureinresponsetoantibioticinducedstress
_version_ 1718395372027510784