Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress

Biofilm formation: Architecture and antibiotics Studying how the architecture of bacterial biofilms can change on exposure to antibiotics could help tackle persistent clinical infections. Enterococcus faecalis is one of the most prevalent bacteria involved in healthcare situations. Its resistance to...

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Auteurs principaux:	Jennifer L. Dale, Jennifer L. Nilson, Aaron M. T. Barnes, Gary M. Dunny
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Microbial ecology QR100-130
Accès en ligne:	https://doaj.org/article/d966cb626f414f7188a6d59db0172cec
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spelling	oai:doaj.org-article:d966cb626f414f7188a6d59db0172cec2021-12-02T11:42:16ZRestructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress10.1038/s41522-017-0023-42055-5008https://doaj.org/article/d966cb626f414f7188a6d59db0172cec2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41522-017-0023-4https://doaj.org/toc/2055-5008Biofilm formation: Architecture and antibiotics Studying how the architecture of bacterial biofilms can change on exposure to antibiotics could help tackle persistent clinical infections. Enterococcus faecalis is one of the most prevalent bacteria involved in healthcare situations. Its resistance to antibiotics is elevated by the formation of biofilms. Gary Dunny and colleagues at the University of Minnesota, USA studied genetic factors related to the response of E. faecalis biofilms to antibiotics. They identified mutations that caused the bacterial cells to produce structurally altered biofilms and found that similar structural alterations were induced in biofilms made by normal cells in the presence of antibiotics. The altered architecture can make the biofilms less stable and therefore more easily disrupted by treatments. Learning more about the mechanisms underlying these structural changes in biofilms might lead to new options in treating antibiotic resistant infections.Jennifer L. DaleJennifer L. NilsonAaron M. T. BarnesGary M. DunnyNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 3, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Jennifer L. Dale Jennifer L. Nilson Aaron M. T. Barnes Gary M. Dunny Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
description	Biofilm formation: Architecture and antibiotics Studying how the architecture of bacterial biofilms can change on exposure to antibiotics could help tackle persistent clinical infections. Enterococcus faecalis is one of the most prevalent bacteria involved in healthcare situations. Its resistance to antibiotics is elevated by the formation of biofilms. Gary Dunny and colleagues at the University of Minnesota, USA studied genetic factors related to the response of E. faecalis biofilms to antibiotics. They identified mutations that caused the bacterial cells to produce structurally altered biofilms and found that similar structural alterations were induced in biofilms made by normal cells in the presence of antibiotics. The altered architecture can make the biofilms less stable and therefore more easily disrupted by treatments. Learning more about the mechanisms underlying these structural changes in biofilms might lead to new options in treating antibiotic resistant infections.
format	article
author	Jennifer L. Dale Jennifer L. Nilson Aaron M. T. Barnes Gary M. Dunny
author_facet	Jennifer L. Dale Jennifer L. Nilson Aaron M. T. Barnes Gary M. Dunny
author_sort	Jennifer L. Dale
title	Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
title_short	Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
title_full	Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
title_fullStr	Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
title_full_unstemmed	Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
title_sort	restructuring of enterococcus faecalis biofilm architecture in response to antibiotic-induced stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d966cb626f414f7188a6d59db0172cec
work_keys_str_mv	AT jenniferldale restructuringofenterococcusfaecalisbiofilmarchitectureinresponsetoantibioticinducedstress AT jenniferlnilson restructuringofenterococcusfaecalisbiofilmarchitectureinresponsetoantibioticinducedstress AT aaronmtbarnes restructuringofenterococcusfaecalisbiofilmarchitectureinresponsetoantibioticinducedstress AT garymdunny restructuringofenterococcusfaecalisbiofilmarchitectureinresponsetoantibioticinducedstress
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Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress

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