Prognostic value of occult lymph node metastases in patients with completely resected esophageal squamous cell carcinoma

Abstract To investigate the prognostic value of occult lymph node metastases (OLNMs) in patients with pathologically lymph node negative (pN0) esophageal squamous cell carcinoma (ESCC). OLNMs were detected in 516 pN0 ESCC patients by immunohistochemical staining. The correlation between the clinicop...

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Autores principales:	Shao-bin Chen, Di-tian Liu, Shu-jie Huang, Hong-rui Weng, Geng Wang, Hua Li, Yu-ping Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d96749730a954f7e84c578fb4c9dd839
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spelling	oai:doaj.org-article:d96749730a954f7e84c578fb4c9dd8392021-12-02T11:57:58ZPrognostic value of occult lymph node metastases in patients with completely resected esophageal squamous cell carcinoma10.1038/s41598-020-79073-92045-2322https://doaj.org/article/d96749730a954f7e84c578fb4c9dd8392020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79073-9https://doaj.org/toc/2045-2322Abstract To investigate the prognostic value of occult lymph node metastases (OLNMs) in patients with pathologically lymph node negative (pN0) esophageal squamous cell carcinoma (ESCC). OLNMs were detected in 516 pN0 ESCC patients by immunohistochemical staining. The correlation between the clinicopathological features and OLNM, and the prognostic value of OLNM was explored. Eighty-eight patients (17.1%) had OLNMs, including 37 patients with isolated tumor cells (ITCs), 49 patients with micrometastases, and 2 patients with macrometastases (> 2 mm). The OLNM-positive group had poorer differentiation and a more advanced pT category. The 5-year overall survival and disease-free survival for patients with OLNMs were significantly worse than those of IHC-negative patients (P < 0.001), but similar to those of the pN1 patients (P > 0.05). The multivariate analysis showed that OLNM was an independent prognostic factor. In subgroup analyses, the IHC-negative patients had significant survival advantages compared with the ITC group and the micrometastasis group, whereas the survival for the ITC group was similar to that of the micrometastasis group. IHC staining in pN0 ESCC patients might help to identify patients at high risk of death after resection, and ITCs in the lymph nodes appear to have a prognostic value equal to that of micrometastases.Shao-bin ChenDi-tian LiuShu-jie HuangHong-rui WengGeng WangHua LiYu-ping ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shao-bin Chen Di-tian Liu Shu-jie Huang Hong-rui Weng Geng Wang Hua Li Yu-ping Chen Prognostic value of occult lymph node metastases in patients with completely resected esophageal squamous cell carcinoma
description	Abstract To investigate the prognostic value of occult lymph node metastases (OLNMs) in patients with pathologically lymph node negative (pN0) esophageal squamous cell carcinoma (ESCC). OLNMs were detected in 516 pN0 ESCC patients by immunohistochemical staining. The correlation between the clinicopathological features and OLNM, and the prognostic value of OLNM was explored. Eighty-eight patients (17.1%) had OLNMs, including 37 patients with isolated tumor cells (ITCs), 49 patients with micrometastases, and 2 patients with macrometastases (> 2 mm). The OLNM-positive group had poorer differentiation and a more advanced pT category. The 5-year overall survival and disease-free survival for patients with OLNMs were significantly worse than those of IHC-negative patients (P < 0.001), but similar to those of the pN1 patients (P > 0.05). The multivariate analysis showed that OLNM was an independent prognostic factor. In subgroup analyses, the IHC-negative patients had significant survival advantages compared with the ITC group and the micrometastasis group, whereas the survival for the ITC group was similar to that of the micrometastasis group. IHC staining in pN0 ESCC patients might help to identify patients at high risk of death after resection, and ITCs in the lymph nodes appear to have a prognostic value equal to that of micrometastases.
format	article
author	Shao-bin Chen Di-tian Liu Shu-jie Huang Hong-rui Weng Geng Wang Hua Li Yu-ping Chen
author_facet	Shao-bin Chen Di-tian Liu Shu-jie Huang Hong-rui Weng Geng Wang Hua Li Yu-ping Chen
author_sort	Shao-bin Chen
title	Prognostic value of occult lymph node metastases in patients with completely resected esophageal squamous cell carcinoma
title_short	Prognostic value of occult lymph node metastases in patients with completely resected esophageal squamous cell carcinoma
title_full	Prognostic value of occult lymph node metastases in patients with completely resected esophageal squamous cell carcinoma
title_fullStr	Prognostic value of occult lymph node metastases in patients with completely resected esophageal squamous cell carcinoma
title_full_unstemmed	Prognostic value of occult lymph node metastases in patients with completely resected esophageal squamous cell carcinoma
title_sort	prognostic value of occult lymph node metastases in patients with completely resected esophageal squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d96749730a954f7e84c578fb4c9dd839
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Prognostic value of occult lymph node metastases in patients with completely resected esophageal squamous cell carcinoma

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