Imaging Markers of Subcortical Vascular Dementia in Patients With Multiple-Lobar Cerebral Microbleeds

Background and Purpose: Small vessel disease (SVD) imaging markers are related to ischemic and hemorrhage stroke and to cognitive dysfunction. This study aimed to clarify the relationship between SVD imaging markers and subcortical vascular dementia in severe SVD burden.Methods: A total of 57 subjec...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chia-Yen Lin, Song-Ru Jhan, Wei-Ju Lee, Po-Lin Chen, Jun-Peng Chen, Hung-Chieh Chen, Ting-Bin Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hypertensive angiopathy amyloid angiopathy lacune microbleed white matter hyperintensities Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d969c2a17d334199bbfe68a68186dc53
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d969c2a17d334199bbfe68a68186dc53
record_format	dspace
spelling	oai:doaj.org-article:d969c2a17d334199bbfe68a68186dc532021-11-12T06:26:33ZImaging Markers of Subcortical Vascular Dementia in Patients With Multiple-Lobar Cerebral Microbleeds1664-229510.3389/fneur.2021.747536https://doaj.org/article/d969c2a17d334199bbfe68a68186dc532021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.747536/fullhttps://doaj.org/toc/1664-2295Background and Purpose: Small vessel disease (SVD) imaging markers are related to ischemic and hemorrhage stroke and to cognitive dysfunction. This study aimed to clarify the relationship between SVD imaging markers and subcortical vascular dementia in severe SVD burden.Methods: A total of 57 subjects with multiple lobar cerebral microbleeds (CMBs) and four established SVD imaging markers were enrolled from the dementia and stroke registries of a single center. Visual rating scales that are used to semi-quantify SVD imaging changes were analyzed individually and compositely to make correlations with cognitive domains and subcortical vascular dementia.Results: Dementia group had higher subcortical and total white matter hyperintensities (WMHs) and SVD composite scores than non-dementia group. Individual imaging markers correlated differently with one another and had distinct cognitive correlations. After adjusting for demographic factors, multivariate logistic regression indicated associations of subcortical WMHs (odds ratio [OR] 2.03, CI 1.24–3.32), total WMHs (OR 1.43, CI 1.09–1.89), lacunes (OR 1.18, CI 1.02–1.35), cerebral amyloid angiopathy-SVD scores (OR 2.33, CI 1.01–5.40), C1 scores (imaging composite scores of CMB and WMH) (OR 1.41, CI 1.09–1.83), and C2 scores (imaging composite scores of CMB, WMH, perivascular space, and lacune) (OR 1.38, CI 1.08–1.76) with dementia.Conclusions: SVD imaging markers might have differing associations with cognitive domains and dementia. They may provide valuable complementary information in support of personalized treatment planning against cognitive impairment, particularly in patients with a heavy SVD load.Chia-Yen LinSong-Ru JhanWei-Ju LeeWei-Ju LeeWei-Ju LeePo-Lin ChenPo-Lin ChenJun-Peng ChenHung-Chieh ChenHung-Chieh ChenTing-Bin ChenTing-Bin ChenTing-Bin ChenFrontiers Media S.A.articlehypertensive angiopathyamyloid angiopathylacunemicrobleedwhite matter hyperintensitiesNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hypertensive angiopathy amyloid angiopathy lacune microbleed white matter hyperintensities Neurology. Diseases of the nervous system RC346-429
spellingShingle	hypertensive angiopathy amyloid angiopathy lacune microbleed white matter hyperintensities Neurology. Diseases of the nervous system RC346-429 Chia-Yen Lin Song-Ru Jhan Wei-Ju Lee Wei-Ju Lee Wei-Ju Lee Po-Lin Chen Po-Lin Chen Jun-Peng Chen Hung-Chieh Chen Hung-Chieh Chen Ting-Bin Chen Ting-Bin Chen Ting-Bin Chen Imaging Markers of Subcortical Vascular Dementia in Patients With Multiple-Lobar Cerebral Microbleeds
description	Background and Purpose: Small vessel disease (SVD) imaging markers are related to ischemic and hemorrhage stroke and to cognitive dysfunction. This study aimed to clarify the relationship between SVD imaging markers and subcortical vascular dementia in severe SVD burden.Methods: A total of 57 subjects with multiple lobar cerebral microbleeds (CMBs) and four established SVD imaging markers were enrolled from the dementia and stroke registries of a single center. Visual rating scales that are used to semi-quantify SVD imaging changes were analyzed individually and compositely to make correlations with cognitive domains and subcortical vascular dementia.Results: Dementia group had higher subcortical and total white matter hyperintensities (WMHs) and SVD composite scores than non-dementia group. Individual imaging markers correlated differently with one another and had distinct cognitive correlations. After adjusting for demographic factors, multivariate logistic regression indicated associations of subcortical WMHs (odds ratio [OR] 2.03, CI 1.24–3.32), total WMHs (OR 1.43, CI 1.09–1.89), lacunes (OR 1.18, CI 1.02–1.35), cerebral amyloid angiopathy-SVD scores (OR 2.33, CI 1.01–5.40), C1 scores (imaging composite scores of CMB and WMH) (OR 1.41, CI 1.09–1.83), and C2 scores (imaging composite scores of CMB, WMH, perivascular space, and lacune) (OR 1.38, CI 1.08–1.76) with dementia.Conclusions: SVD imaging markers might have differing associations with cognitive domains and dementia. They may provide valuable complementary information in support of personalized treatment planning against cognitive impairment, particularly in patients with a heavy SVD load.
format	article
author	Chia-Yen Lin Song-Ru Jhan Wei-Ju Lee Wei-Ju Lee Wei-Ju Lee Po-Lin Chen Po-Lin Chen Jun-Peng Chen Hung-Chieh Chen Hung-Chieh Chen Ting-Bin Chen Ting-Bin Chen Ting-Bin Chen
author_facet	Chia-Yen Lin Song-Ru Jhan Wei-Ju Lee Wei-Ju Lee Wei-Ju Lee Po-Lin Chen Po-Lin Chen Jun-Peng Chen Hung-Chieh Chen Hung-Chieh Chen Ting-Bin Chen Ting-Bin Chen Ting-Bin Chen
author_sort	Chia-Yen Lin
title	Imaging Markers of Subcortical Vascular Dementia in Patients With Multiple-Lobar Cerebral Microbleeds
title_short	Imaging Markers of Subcortical Vascular Dementia in Patients With Multiple-Lobar Cerebral Microbleeds
title_full	Imaging Markers of Subcortical Vascular Dementia in Patients With Multiple-Lobar Cerebral Microbleeds
title_fullStr	Imaging Markers of Subcortical Vascular Dementia in Patients With Multiple-Lobar Cerebral Microbleeds
title_full_unstemmed	Imaging Markers of Subcortical Vascular Dementia in Patients With Multiple-Lobar Cerebral Microbleeds
title_sort	imaging markers of subcortical vascular dementia in patients with multiple-lobar cerebral microbleeds
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d969c2a17d334199bbfe68a68186dc53
work_keys_str_mv	AT chiayenlin imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT songrujhan imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT weijulee imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT weijulee imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT weijulee imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT polinchen imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT polinchen imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT junpengchen imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT hungchiehchen imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT hungchiehchen imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT tingbinchen imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT tingbinchen imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds AT tingbinchen imagingmarkersofsubcorticalvasculardementiainpatientswithmultiplelobarcerebralmicrobleeds
_version_	1718431199375917056

Imaging Markers of Subcortical Vascular Dementia in Patients With Multiple-Lobar Cerebral Microbleeds

Ejemplares similares