Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.

To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (desi...

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Autores principales:	Michael Mayerhofer, Andreas Bergmaier, Gerd Datzmann, Hermann Hagn, Ricardo Helm, Johannes Mitteneder, Ralf Schubert, Luigi Picardi, Paolo Nenzi, Concetta Ronsivalle, Hans-Friedrich Wirth, Günther Dollinger
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d96a0edb9f7a46edb82f2a467847e3e1
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spelling	oai:doaj.org-article:d96a0edb9f7a46edb82f2a467847e3e12021-12-02T20:17:03ZConcept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.1932-620310.1371/journal.pone.0258477https://doaj.org/article/d96a0edb9f7a46edb82f2a467847e3e12021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258477https://doaj.org/toc/1932-6203To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (designs: AVO-ADAM S.A, Geneva, Switzerland and ENEA, Frascati, Italy). To enhance the transmission of the tandem beam through the post-accelerator by a factor of 3, two drift tube buncher units were designed and constructed: A brazed 5-gap structure (adapted SCDTL tank of the TOP-IMPLART project (ENEA)) and a non-brazed low budget 4-gap structure. Both are made of copper. The performance of the two differently manufactured units was evaluated using a 16 MeV tandem accelerator beam and a Q3D magnetic spectrograph. Both buncher units achieve the required summed voltage amplitude of 42 kV and amplitude stability at a power feed of less than 800 W.Michael MayerhoferAndreas BergmaierGerd DatzmannHermann HagnRicardo HelmJohannes MittenederRalf SchubertLuigi PicardiPaolo NenziConcetta RonsivalleHans-Friedrich WirthGünther DollingerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258477 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael Mayerhofer Andreas Bergmaier Gerd Datzmann Hermann Hagn Ricardo Helm Johannes Mitteneder Ralf Schubert Luigi Picardi Paolo Nenzi Concetta Ronsivalle Hans-Friedrich Wirth Günther Dollinger Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.
description	To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (designs: AVO-ADAM S.A, Geneva, Switzerland and ENEA, Frascati, Italy). To enhance the transmission of the tandem beam through the post-accelerator by a factor of 3, two drift tube buncher units were designed and constructed: A brazed 5-gap structure (adapted SCDTL tank of the TOP-IMPLART project (ENEA)) and a non-brazed low budget 4-gap structure. Both are made of copper. The performance of the two differently manufactured units was evaluated using a 16 MeV tandem accelerator beam and a Q3D magnetic spectrograph. Both buncher units achieve the required summed voltage amplitude of 42 kV and amplitude stability at a power feed of less than 800 W.
format	article
author	Michael Mayerhofer Andreas Bergmaier Gerd Datzmann Hermann Hagn Ricardo Helm Johannes Mitteneder Ralf Schubert Luigi Picardi Paolo Nenzi Concetta Ronsivalle Hans-Friedrich Wirth Günther Dollinger
author_facet	Michael Mayerhofer Andreas Bergmaier Gerd Datzmann Hermann Hagn Ricardo Helm Johannes Mitteneder Ralf Schubert Luigi Picardi Paolo Nenzi Concetta Ronsivalle Hans-Friedrich Wirth Günther Dollinger
author_sort	Michael Mayerhofer
title	Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.
title_short	Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.
title_full	Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.
title_fullStr	Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.
title_full_unstemmed	Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.
title_sort	concept and performance evaluation of two 3 ghz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d96a0edb9f7a46edb82f2a467847e3e1
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Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.

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