Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting

Cation-proton antiporters mediate selective ion exchange across cellular membranes to control pH, salt concentration and cell volume. Here the authors present a transition-path sampling method that overcomes the timescale gap between simulations (µs) and transport processes (s), which allows them to...

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Autores principales:	Kei-ichi Okazaki, David Wöhlert, Judith Warnau, Hendrik Jung, Özkan Yildiz, Werner Kühlbrandt, Gerhard Hummer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d96f57b101b645f8954b444ea2b082fa
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spelling	oai:doaj.org-article:d96f57b101b645f8954b444ea2b082fa2021-12-02T16:58:26ZMechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting10.1038/s41467-019-09739-02041-1723https://doaj.org/article/d96f57b101b645f8954b444ea2b082fa2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09739-0https://doaj.org/toc/2041-1723Cation-proton antiporters mediate selective ion exchange across cellular membranes to control pH, salt concentration and cell volume. Here the authors present a transition-path sampling method that overcomes the timescale gap between simulations (µs) and transport processes (s), which allows them to resolve the Na+ and H+ transport cycle of the Na+/H+ antiporter NhaP from Pyrococcus abyssi.Kei-ichi OkazakiDavid WöhlertJudith WarnauHendrik JungÖzkan YildizWerner KühlbrandtGerhard HummerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kei-ichi Okazaki David Wöhlert Judith Warnau Hendrik Jung Özkan Yildiz Werner Kühlbrandt Gerhard Hummer Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
description	Cation-proton antiporters mediate selective ion exchange across cellular membranes to control pH, salt concentration and cell volume. Here the authors present a transition-path sampling method that overcomes the timescale gap between simulations (µs) and transport processes (s), which allows them to resolve the Na+ and H+ transport cycle of the Na+/H+ antiporter NhaP from Pyrococcus abyssi.
format	article
author	Kei-ichi Okazaki David Wöhlert Judith Warnau Hendrik Jung Özkan Yildiz Werner Kühlbrandt Gerhard Hummer
author_facet	Kei-ichi Okazaki David Wöhlert Judith Warnau Hendrik Jung Özkan Yildiz Werner Kühlbrandt Gerhard Hummer
author_sort	Kei-ichi Okazaki
title	Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
title_short	Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
title_full	Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
title_fullStr	Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
title_full_unstemmed	Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting
title_sort	mechanism of the electroneutral sodium/proton antiporter panhap from transition-path shooting
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d96f57b101b645f8954b444ea2b082fa
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Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting

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