Short-Term Relocation Stress-Induced Hematological and Immunological Changes in Saimiri boliviensis boliviensis

Nonhuman primates are frequently transported to a new location or temporarily relocated within their colony. Both transportation and relocation expose animals to new environments, causing them to undergo a stress response (before adapting). In our NHP colony, the mentioned situations are not infrequ...

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Autores principales:	Pramod N. Nehete, Bharti P. Nehete, Akash G. Patel, Sriram Chitta, Henrieta Scholtzova, Lawrence E. Williams
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d9706f9b82c340d581b00ba74b266e7b
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spelling	oai:doaj.org-article:d9706f9b82c340d581b00ba74b266e7b2021-11-29T00:55:41ZShort-Term Relocation Stress-Induced Hematological and Immunological Changes in Saimiri boliviensis boliviensis2314-715610.1155/2021/5318590https://doaj.org/article/d9706f9b82c340d581b00ba74b266e7b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5318590https://doaj.org/toc/2314-7156Nonhuman primates are frequently transported to a new location or temporarily relocated within their colony. Both transportation and relocation expose animals to new environments, causing them to undergo a stress response (before adapting). In our NHP colony, the mentioned situations are not infrequent for many reasons, including maintenance. The objective of this study was to determine whether abrupt changes consisting of relocation, housing, separation, and grouping could influence hematological and immunological parameters and thereby functional activity. The current study used squirrel monkeys as a model to investigate the stress-inducing effects of relocation within a facility, while animals acclimated to new situations (physical, housing). A detailed blood analysis revealed significant changes in lymphocytes, triglycerides, total protein, creatinine, and ALT. Flow cytometric analysis of peripheral blood showed reduction in CD3+, CD4+, and CD8+ T cells and monocytes, while B cells and natural killer (NK) cells changed with relocation. Simultaneously, changes in functional activity of immune cells altered proliferative responses and as shown by ELISpot (IFN γ). Though the parameters studied are not affected as severely as those in animals transported by road or air, stress responses induced by intrafacility relocation are significant and worth consideration. Our findings indicate that squirrel monkeys mimic the features seen in humans exposed to social stressors and may serve an important model for understanding the mechanisms of stress-induced immune dysfunction in humans.Pramod N. NeheteBharti P. NeheteAkash G. PatelSriram ChittaHenrieta ScholtzovaLawrence E. WilliamsHindawi LimitedarticleImmunologic diseases. AllergyRC581-607ENJournal of Immunology Research, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607
spellingShingle	Immunologic diseases. Allergy RC581-607 Pramod N. Nehete Bharti P. Nehete Akash G. Patel Sriram Chitta Henrieta Scholtzova Lawrence E. Williams Short-Term Relocation Stress-Induced Hematological and Immunological Changes in Saimiri boliviensis boliviensis
description	Nonhuman primates are frequently transported to a new location or temporarily relocated within their colony. Both transportation and relocation expose animals to new environments, causing them to undergo a stress response (before adapting). In our NHP colony, the mentioned situations are not infrequent for many reasons, including maintenance. The objective of this study was to determine whether abrupt changes consisting of relocation, housing, separation, and grouping could influence hematological and immunological parameters and thereby functional activity. The current study used squirrel monkeys as a model to investigate the stress-inducing effects of relocation within a facility, while animals acclimated to new situations (physical, housing). A detailed blood analysis revealed significant changes in lymphocytes, triglycerides, total protein, creatinine, and ALT. Flow cytometric analysis of peripheral blood showed reduction in CD3+, CD4+, and CD8+ T cells and monocytes, while B cells and natural killer (NK) cells changed with relocation. Simultaneously, changes in functional activity of immune cells altered proliferative responses and as shown by ELISpot (IFN γ). Though the parameters studied are not affected as severely as those in animals transported by road or air, stress responses induced by intrafacility relocation are significant and worth consideration. Our findings indicate that squirrel monkeys mimic the features seen in humans exposed to social stressors and may serve an important model for understanding the mechanisms of stress-induced immune dysfunction in humans.
format	article
author	Pramod N. Nehete Bharti P. Nehete Akash G. Patel Sriram Chitta Henrieta Scholtzova Lawrence E. Williams
author_facet	Pramod N. Nehete Bharti P. Nehete Akash G. Patel Sriram Chitta Henrieta Scholtzova Lawrence E. Williams
author_sort	Pramod N. Nehete
title	Short-Term Relocation Stress-Induced Hematological and Immunological Changes in Saimiri boliviensis boliviensis
title_short	Short-Term Relocation Stress-Induced Hematological and Immunological Changes in Saimiri boliviensis boliviensis
title_full	Short-Term Relocation Stress-Induced Hematological and Immunological Changes in Saimiri boliviensis boliviensis
title_fullStr	Short-Term Relocation Stress-Induced Hematological and Immunological Changes in Saimiri boliviensis boliviensis
title_full_unstemmed	Short-Term Relocation Stress-Induced Hematological and Immunological Changes in Saimiri boliviensis boliviensis
title_sort	short-term relocation stress-induced hematological and immunological changes in saimiri boliviensis boliviensis
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/d9706f9b82c340d581b00ba74b266e7b
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Short-Term Relocation Stress-Induced Hematological and Immunological Changes in Saimiri boliviensis boliviensis

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