How to make evolution-proof insecticides for malaria control.

Insecticides are one of the cheapest, most effective, and best proven methods of controlling malaria, but mosquitoes can rapidly evolve resistance. Such evolution, first seen in the 1950s in areas of widespread DDT use, is a major challenge because attempts to comprehensively control and even elimin...

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Autores principales:	Andrew F Read, Penelope A Lynch, Matthew B Thomas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d972821e33764ac98e12c104b657df1c
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spelling	oai:doaj.org-article:d972821e33764ac98e12c104b657df1c2021-11-25T05:33:44ZHow to make evolution-proof insecticides for malaria control.1544-91731545-788510.1371/journal.pbio.1000058https://doaj.org/article/d972821e33764ac98e12c104b657df1c2009-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19355786/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Insecticides are one of the cheapest, most effective, and best proven methods of controlling malaria, but mosquitoes can rapidly evolve resistance. Such evolution, first seen in the 1950s in areas of widespread DDT use, is a major challenge because attempts to comprehensively control and even eliminate malaria rely heavily on indoor house spraying and insecticide-treated bed nets. Current strategies for dealing with resistance evolution are expensive and open ended, and their sustainability has yet to be demonstrated. Here we show that if insecticides targeted old mosquitoes, and ideally old malaria-infected mosquitoes, they could provide effective malaria control while only weakly selecting for resistance. This alone would greatly enhance the useful life span of an insecticide. However,such weak selection for resistance can easily be overwhelmed if resistance is associated with fitness costs. In that case, late-life-acting insecticides would never be undermined by mosquito evolution.We discuss a number of practical ways to achieve this, including different use of existing chemical insecticides,biopesticides, and novel chemistry. Done right, a one-off investment in a single insecticide would solve the problem of mosquito resistance forever.Andrew F ReadPenelope A LynchMatthew B ThomasPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 7, Iss 4, p e1000058 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Andrew F Read Penelope A Lynch Matthew B Thomas How to make evolution-proof insecticides for malaria control.
description	Insecticides are one of the cheapest, most effective, and best proven methods of controlling malaria, but mosquitoes can rapidly evolve resistance. Such evolution, first seen in the 1950s in areas of widespread DDT use, is a major challenge because attempts to comprehensively control and even eliminate malaria rely heavily on indoor house spraying and insecticide-treated bed nets. Current strategies for dealing with resistance evolution are expensive and open ended, and their sustainability has yet to be demonstrated. Here we show that if insecticides targeted old mosquitoes, and ideally old malaria-infected mosquitoes, they could provide effective malaria control while only weakly selecting for resistance. This alone would greatly enhance the useful life span of an insecticide. However,such weak selection for resistance can easily be overwhelmed if resistance is associated with fitness costs. In that case, late-life-acting insecticides would never be undermined by mosquito evolution.We discuss a number of practical ways to achieve this, including different use of existing chemical insecticides,biopesticides, and novel chemistry. Done right, a one-off investment in a single insecticide would solve the problem of mosquito resistance forever.
format	article
author	Andrew F Read Penelope A Lynch Matthew B Thomas
author_facet	Andrew F Read Penelope A Lynch Matthew B Thomas
author_sort	Andrew F Read
title	How to make evolution-proof insecticides for malaria control.
title_short	How to make evolution-proof insecticides for malaria control.
title_full	How to make evolution-proof insecticides for malaria control.
title_fullStr	How to make evolution-proof insecticides for malaria control.
title_full_unstemmed	How to make evolution-proof insecticides for malaria control.
title_sort	how to make evolution-proof insecticides for malaria control.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/d972821e33764ac98e12c104b657df1c
work_keys_str_mv	AT andrewfread howtomakeevolutionproofinsecticidesformalariacontrol AT penelopealynch howtomakeevolutionproofinsecticidesformalariacontrol AT matthewbthomas howtomakeevolutionproofinsecticidesformalariacontrol
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How to make evolution-proof insecticides for malaria control.

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