Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations

Abstract Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption...

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Autores principales:	Jessica L. Cooperstone, Kathleen L. Tober, Ken M. Riedl, Matthew D. Teegarden, Morgan J. Cichon, David M. Francis, Steven J. Schwartz, Tatiana M. Oberyszyn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d973517e38364948a0aa953cfed6d45e
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spelling	oai:doaj.org-article:d973517e38364948a0aa953cfed6d45e2021-12-02T12:32:52ZTomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations10.1038/s41598-017-05568-72045-2322https://doaj.org/article/d973517e38364948a0aa953cfed6d45e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05568-7https://doaj.org/toc/2045-2322Abstract Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin cancer. SKH-1 hairless and immunocompetent mice (n = 180) were fed AIN-93G or AIN-93G + 10% tangerine or red tomato powder for 35 weeks. From weeks 11–20, mice (n = 120) were exposed to 2240 J/m2 UV-B light, 3x/week, and tumors were tracked weekly. Control mice were fed the same diets but not exposed to UV. Tumor number was significantly lower in male mice consuming red tomato diets (1.73 ± 0.50, P = 0.015) or pooled tomato diets (2.03 ± 0.45, P = 0.017) compared to controls (4.04 ± 0.65). Carotenoid levels in plasma and skin were quantitated, with total lycopene higher in skin of tangerine fed animals despite a lower dose. Metabolomic analyses elucidated compounds derived from tomato glycoalkaloids (including tomatidine and hydroxylated-tomatidine) as significantly different metabolites in skin after tomato exposure. Here, we describe that tomato consumption can modulate risk for keratinocyte carcinomas; however, the role of the newly identified specific phytochemicals possibly responsible for this action require further investigation.Jessica L. CooperstoneKathleen L. ToberKen M. RiedlMatthew D. TeegardenMorgan J. CichonDavid M. FrancisSteven J. SchwartzTatiana M. OberyszynNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jessica L. Cooperstone Kathleen L. Tober Ken M. Riedl Matthew D. Teegarden Morgan J. Cichon David M. Francis Steven J. Schwartz Tatiana M. Oberyszyn Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations
description	Abstract Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin cancer. SKH-1 hairless and immunocompetent mice (n = 180) were fed AIN-93G or AIN-93G + 10% tangerine or red tomato powder for 35 weeks. From weeks 11–20, mice (n = 120) were exposed to 2240 J/m2 UV-B light, 3x/week, and tumors were tracked weekly. Control mice were fed the same diets but not exposed to UV. Tumor number was significantly lower in male mice consuming red tomato diets (1.73 ± 0.50, P = 0.015) or pooled tomato diets (2.03 ± 0.45, P = 0.017) compared to controls (4.04 ± 0.65). Carotenoid levels in plasma and skin were quantitated, with total lycopene higher in skin of tangerine fed animals despite a lower dose. Metabolomic analyses elucidated compounds derived from tomato glycoalkaloids (including tomatidine and hydroxylated-tomatidine) as significantly different metabolites in skin after tomato exposure. Here, we describe that tomato consumption can modulate risk for keratinocyte carcinomas; however, the role of the newly identified specific phytochemicals possibly responsible for this action require further investigation.
format	article
author	Jessica L. Cooperstone Kathleen L. Tober Ken M. Riedl Matthew D. Teegarden Morgan J. Cichon David M. Francis Steven J. Schwartz Tatiana M. Oberyszyn
author_facet	Jessica L. Cooperstone Kathleen L. Tober Ken M. Riedl Matthew D. Teegarden Morgan J. Cichon David M. Francis Steven J. Schwartz Tatiana M. Oberyszyn
author_sort	Jessica L. Cooperstone
title	Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations
title_short	Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations
title_full	Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations
title_fullStr	Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations
title_full_unstemmed	Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations
title_sort	tomatoes protect against development of uv-induced keratinocyte carcinoma via metabolomic alterations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d973517e38364948a0aa953cfed6d45e
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Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations

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