Protective effect of thymoquinone against lung intoxication induced by malathion inhalation

Abstract Malathion is considered one of the vastest pesticides use all over the world. Malathion-inhalation toxicity commonly occurred in many occupational farmers. Therefore, this study aimed to ameliorate the possible malathion-induced pulmonary toxicity through thymoquinone administration. Forty...

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Autores principales:	Walied Abdo, Mostafa A. Elmadawy, Ehab Yahya Abdelhiee, Mona A. Abdel-Kareem, Amira Farag, Mohamed Aboubakr, Emad Ghazy, Sabreen E. Fadl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9744746283e463ea16ea26e78c96bfe
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spelling	oai:doaj.org-article:d9744746283e463ea16ea26e78c96bfe2021-12-02T13:57:58ZProtective effect of thymoquinone against lung intoxication induced by malathion inhalation10.1038/s41598-021-82083-w2045-2322https://doaj.org/article/d9744746283e463ea16ea26e78c96bfe2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82083-whttps://doaj.org/toc/2045-2322Abstract Malathion is considered one of the vastest pesticides use all over the world. Malathion-inhalation toxicity commonly occurred in many occupational farmers. Therefore, this study aimed to ameliorate the possible malathion-induced pulmonary toxicity through thymoquinone administration. Forty animals were used to conduct our study, divided into five groups; G1 control group, G2 thymoquinone (50 mg/kg) group, G3 malathion group (animals inhaled 100 mg/ml/m3 for 15 min for 5 days/week for three weeks), G4 and G5 were subjected to the same malathion inhalation protocol beside oral thymoquinone administration at doses of 25 and 50 (mg/kg), respectively. Malathion-inhalation induced marked systemic toxicity as hepatotoxicity and nephrotoxicity associated with increased serum hepatic and renal enzymes, and hypersensitivity accompanied with increased total IgE serum level. The lung showed severe interstitial pneumonia associated with severe vascular damage and marked eosinophil infiltration. Moreover, the lung showed a marked decrease in the pulmonary surfactant protein, especially SP-D gene expression. While, thymoquinone treatment to malathion-inhaled animals decremented the following; hepatic enzymes and renal function tests, total IgE as well as pneumonia and hypersensitivity pathological features, and augmented the expression of SP-D. In conclusion, thymoquinone could be potentially used in pest control workers to ameliorate the systemic and pulmonary intoxication caused by one of the most field-used pesticides.Walied AbdoMostafa A. ElmadawyEhab Yahya AbdelhieeMona A. Abdel-KareemAmira FaragMohamed AboubakrEmad GhazySabreen E. FadlNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Walied Abdo Mostafa A. Elmadawy Ehab Yahya Abdelhiee Mona A. Abdel-Kareem Amira Farag Mohamed Aboubakr Emad Ghazy Sabreen E. Fadl Protective effect of thymoquinone against lung intoxication induced by malathion inhalation
description	Abstract Malathion is considered one of the vastest pesticides use all over the world. Malathion-inhalation toxicity commonly occurred in many occupational farmers. Therefore, this study aimed to ameliorate the possible malathion-induced pulmonary toxicity through thymoquinone administration. Forty animals were used to conduct our study, divided into five groups; G1 control group, G2 thymoquinone (50 mg/kg) group, G3 malathion group (animals inhaled 100 mg/ml/m3 for 15 min for 5 days/week for three weeks), G4 and G5 were subjected to the same malathion inhalation protocol beside oral thymoquinone administration at doses of 25 and 50 (mg/kg), respectively. Malathion-inhalation induced marked systemic toxicity as hepatotoxicity and nephrotoxicity associated with increased serum hepatic and renal enzymes, and hypersensitivity accompanied with increased total IgE serum level. The lung showed severe interstitial pneumonia associated with severe vascular damage and marked eosinophil infiltration. Moreover, the lung showed a marked decrease in the pulmonary surfactant protein, especially SP-D gene expression. While, thymoquinone treatment to malathion-inhaled animals decremented the following; hepatic enzymes and renal function tests, total IgE as well as pneumonia and hypersensitivity pathological features, and augmented the expression of SP-D. In conclusion, thymoquinone could be potentially used in pest control workers to ameliorate the systemic and pulmonary intoxication caused by one of the most field-used pesticides.
format	article
author	Walied Abdo Mostafa A. Elmadawy Ehab Yahya Abdelhiee Mona A. Abdel-Kareem Amira Farag Mohamed Aboubakr Emad Ghazy Sabreen E. Fadl
author_facet	Walied Abdo Mostafa A. Elmadawy Ehab Yahya Abdelhiee Mona A. Abdel-Kareem Amira Farag Mohamed Aboubakr Emad Ghazy Sabreen E. Fadl
author_sort	Walied Abdo
title	Protective effect of thymoquinone against lung intoxication induced by malathion inhalation
title_short	Protective effect of thymoquinone against lung intoxication induced by malathion inhalation
title_full	Protective effect of thymoquinone against lung intoxication induced by malathion inhalation
title_fullStr	Protective effect of thymoquinone against lung intoxication induced by malathion inhalation
title_full_unstemmed	Protective effect of thymoquinone against lung intoxication induced by malathion inhalation
title_sort	protective effect of thymoquinone against lung intoxication induced by malathion inhalation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d9744746283e463ea16ea26e78c96bfe
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Protective effect of thymoquinone against lung intoxication induced by malathion inhalation

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