Allostery through DNA drives phenotype switching

Allostery through DNA drives phenotype switching

Most insights on DNA-mediated allostery upon transcription factor (TF) binding were either based on artificial promoters or found to be short-ranged. Here authors use single-molecule FRET and cryo-EM to show that Bacillus subtilis bacteria utilize long-range allostery in a stochastic and reversible...

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Autores principales: Gabriel Rosenblum, Nadav Elad, Haim Rozenberg, Felix Wiggers, Jakub Jungwirth, Hagen Hofmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/d98248e72e7a43afad2cce3d9fb3924e
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spelling oai:doaj.org-article:d98248e72e7a43afad2cce3d9fb3924e2021-12-02T15:45:24ZAllostery through DNA drives phenotype switching10.1038/s41467-021-23148-22041-1723https://doaj.org/article/d98248e72e7a43afad2cce3d9fb3924e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23148-2https://doaj.org/toc/2041-1723Most insights on DNA-mediated allostery upon transcription factor (TF) binding were either based on artificial promoters or found to be short-ranged. Here authors use single-molecule FRET and cryo-EM to show that Bacillus subtilis bacteria utilize long-range allostery in a stochastic and reversible phenotype switch.Gabriel RosenblumNadav EladHaim RozenbergFelix WiggersJakub JungwirthHagen HofmannNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gabriel Rosenblum
Nadav Elad
Haim Rozenberg
Felix Wiggers
Jakub Jungwirth
Hagen Hofmann
Allostery through DNA drives phenotype switching
description Most insights on DNA-mediated allostery upon transcription factor (TF) binding were either based on artificial promoters or found to be short-ranged. Here authors use single-molecule FRET and cryo-EM to show that Bacillus subtilis bacteria utilize long-range allostery in a stochastic and reversible phenotype switch.
format article
author Gabriel Rosenblum
Nadav Elad
Haim Rozenberg
Felix Wiggers
Jakub Jungwirth
Hagen Hofmann
author_facet Gabriel Rosenblum
Nadav Elad
Haim Rozenberg
Felix Wiggers
Jakub Jungwirth
Hagen Hofmann
author_sort Gabriel Rosenblum
title Allostery through DNA drives phenotype switching
title_short Allostery through DNA drives phenotype switching
title_full Allostery through DNA drives phenotype switching
title_fullStr Allostery through DNA drives phenotype switching
title_full_unstemmed Allostery through DNA drives phenotype switching
title_sort allostery through dna drives phenotype switching
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d98248e72e7a43afad2cce3d9fb3924e
work_keys_str_mv AT gabrielrosenblum allosterythroughdnadrivesphenotypeswitching
AT nadavelad allosterythroughdnadrivesphenotypeswitching
AT haimrozenberg allosterythroughdnadrivesphenotypeswitching
AT felixwiggers allosterythroughdnadrivesphenotypeswitching
AT jakubjungwirth allosterythroughdnadrivesphenotypeswitching
AT hagenhofmann allosterythroughdnadrivesphenotypeswitching
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