EXPRESSION OF рSTAT3 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD MONONUCLEAR CELLS AND ITS LEPTIN-INDUCED MODULATION IN BRONCHIAL ASTHMA

The aim of this study was to evaluate expression rates of phosphorylated STAT3 (рSTAT3) transcription factor in peripheral blood mononuclear cells (PBMC) and some features of its modulation by leptin in various clinical forma of bronchial asthma (BA). Materials and methods. We evaluated 25 healthy p...

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Autores principales:	V. N. Mineev, T. M. Lalaeva, T. S. Vasilieva, A. A. Kuzmina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	leptin stat-3 bronchial asthma Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d987c631aef94ff7bdb7cd1c9dc42e53
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spelling	oai:doaj.org-article:d987c631aef94ff7bdb7cd1c9dc42e532021-11-18T08:03:44ZEXPRESSION OF рSTAT3 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD MONONUCLEAR CELLS AND ITS LEPTIN-INDUCED MODULATION IN BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2014-6-551-558https://doaj.org/article/d987c631aef94ff7bdb7cd1c9dc42e532015-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/767https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of this study was to evaluate expression rates of phosphorylated STAT3 (рSTAT3) transcription factor in peripheral blood mononuclear cells (PBMC) and some features of its modulation by leptin in various clinical forma of bronchial asthma (BA). Materials and methods. We evaluated 25 healthy persons and 62 BA patients. pSTAT3 expression in PBMC was measured by means of flow cytometry.Results. A phenomenon of increased pSTAT3 expression was registered in PBMC from BA patients. A most sufficient elevation of pSTAT3 levels was revealed in allergic clinical variant of the disorder. Leptin was shown to increase pSTAT3 expression in PBMCs from healthy persons only. In allergic BA, such effect of leptin was not observed, whereas a trend for pSTAT increase was shown in non-allergic BA. In allergic BA, we have revealed a direct correlation between the STAT3-mediated leptin signaling index and bronchial patency parameters. Appropriate inverse correlation was registered in non-allergic BA.Conclusion. We have revealed some characteristics of рSTAT3 expression in PBMCs and its modulation by leptin in various clinical forms of BA, thus providing a potential basis for development of targeted therapy aimed for transduction of different cytokine signals mediated by STAT3 transcription factor.V. N. MineevT. M. LalaevaT. S. VasilievaA. A. KuzminaSPb RAACIarticleleptinstat-3bronchial asthmaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 6, Pp 551-558 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	leptin stat-3 bronchial asthma Immunologic diseases. Allergy RC581-607
spellingShingle	leptin stat-3 bronchial asthma Immunologic diseases. Allergy RC581-607 V. N. Mineev T. M. Lalaeva T. S. Vasilieva A. A. Kuzmina EXPRESSION OF рSTAT3 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD MONONUCLEAR CELLS AND ITS LEPTIN-INDUCED MODULATION IN BRONCHIAL ASTHMA
description	The aim of this study was to evaluate expression rates of phosphorylated STAT3 (рSTAT3) transcription factor in peripheral blood mononuclear cells (PBMC) and some features of its modulation by leptin in various clinical forma of bronchial asthma (BA). Materials and methods. We evaluated 25 healthy persons and 62 BA patients. pSTAT3 expression in PBMC was measured by means of flow cytometry.Results. A phenomenon of increased pSTAT3 expression was registered in PBMC from BA patients. A most sufficient elevation of pSTAT3 levels was revealed in allergic clinical variant of the disorder. Leptin was shown to increase pSTAT3 expression in PBMCs from healthy persons only. In allergic BA, such effect of leptin was not observed, whereas a trend for pSTAT increase was shown in non-allergic BA. In allergic BA, we have revealed a direct correlation between the STAT3-mediated leptin signaling index and bronchial patency parameters. Appropriate inverse correlation was registered in non-allergic BA.Conclusion. We have revealed some characteristics of рSTAT3 expression in PBMCs and its modulation by leptin in various clinical forms of BA, thus providing a potential basis for development of targeted therapy aimed for transduction of different cytokine signals mediated by STAT3 transcription factor.
format	article
author	V. N. Mineev T. M. Lalaeva T. S. Vasilieva A. A. Kuzmina
author_facet	V. N. Mineev T. M. Lalaeva T. S. Vasilieva A. A. Kuzmina
author_sort	V. N. Mineev
title	EXPRESSION OF рSTAT3 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD MONONUCLEAR CELLS AND ITS LEPTIN-INDUCED MODULATION IN BRONCHIAL ASTHMA
title_short	EXPRESSION OF рSTAT3 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD MONONUCLEAR CELLS AND ITS LEPTIN-INDUCED MODULATION IN BRONCHIAL ASTHMA
title_full	EXPRESSION OF рSTAT3 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD MONONUCLEAR CELLS AND ITS LEPTIN-INDUCED MODULATION IN BRONCHIAL ASTHMA
title_fullStr	EXPRESSION OF рSTAT3 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD MONONUCLEAR CELLS AND ITS LEPTIN-INDUCED MODULATION IN BRONCHIAL ASTHMA
title_full_unstemmed	EXPRESSION OF рSTAT3 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD MONONUCLEAR CELLS AND ITS LEPTIN-INDUCED MODULATION IN BRONCHIAL ASTHMA
title_sort	expression of рstat3 transcription factor in peripheral blood mononuclear cells and its leptin-induced modulation in bronchial asthma
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/d987c631aef94ff7bdb7cd1c9dc42e53
work_keys_str_mv	AT vnmineev expressionofrstat3transcriptionfactorinperipheralbloodmononuclearcellsanditsleptininducedmodulationinbronchialasthma AT tmlalaeva expressionofrstat3transcriptionfactorinperipheralbloodmononuclearcellsanditsleptininducedmodulationinbronchialasthma AT tsvasilieva expressionofrstat3transcriptionfactorinperipheralbloodmononuclearcellsanditsleptininducedmodulationinbronchialasthma AT aakuzmina expressionofrstat3transcriptionfactorinperipheralbloodmononuclearcellsanditsleptininducedmodulationinbronchialasthma
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EXPRESSION OF рSTAT3 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD MONONUCLEAR CELLS AND ITS LEPTIN-INDUCED MODULATION IN BRONCHIAL ASTHMA

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