Multi-pinhole fluorescent x-ray computed tomography for molecular imaging

Abstract We propose a multi-pinhole fluorescent x-ray computed tomography (mp-FXCT) technique for preclinical molecular imaging that can provide the complete data necessary to produce 3-D tomographic images during anaesthesia. In this method, multiple projections are simultaneously acquired through...

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Autores principales:	Tenta Sasaya, Naoki Sunaguchi, Kazuyuki Hyodo, Tsutomu Zeniya, Tetsuya Yuasa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d988c5ee89eb4340859c19f76b4cc04f
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spelling	oai:doaj.org-article:d988c5ee89eb4340859c19f76b4cc04f2021-12-02T16:06:48ZMulti-pinhole fluorescent x-ray computed tomography for molecular imaging10.1038/s41598-017-05179-22045-2322https://doaj.org/article/d988c5ee89eb4340859c19f76b4cc04f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05179-2https://doaj.org/toc/2045-2322Abstract We propose a multi-pinhole fluorescent x-ray computed tomography (mp-FXCT) technique for preclinical molecular imaging that can provide the complete data necessary to produce 3-D tomographic images during anaesthesia. In this method, multiple projections are simultaneously acquired through a multi-pinhole collimator with a 2-D detector and full-field volumetric beam to accelerate the data acquisition process and enhance the signal-to-noise ratios of the projections. We constructed a 15-pinhole mp-FXCT imaging system at beamline ARNE-7A at KEK and performed preliminary experiments to investigate its imaging properties using physical phantoms and a non-radioactive I imaging agent. The mp-FXCT system could detect an I concentration of 0.038 mg/ml, the minimum required for in-vivo imaging, at a spatial resolution of about 0.3 mm during a data acquisition time of 90 min, which is less than the time for which anaesthesia is effective and suggests that preclinical molecular imaging is feasible with mp-FXCT.Tenta SasayaNaoki SunaguchiKazuyuki HyodoTsutomu ZeniyaTetsuya YuasaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tenta Sasaya Naoki Sunaguchi Kazuyuki Hyodo Tsutomu Zeniya Tetsuya Yuasa Multi-pinhole fluorescent x-ray computed tomography for molecular imaging
description	Abstract We propose a multi-pinhole fluorescent x-ray computed tomography (mp-FXCT) technique for preclinical molecular imaging that can provide the complete data necessary to produce 3-D tomographic images during anaesthesia. In this method, multiple projections are simultaneously acquired through a multi-pinhole collimator with a 2-D detector and full-field volumetric beam to accelerate the data acquisition process and enhance the signal-to-noise ratios of the projections. We constructed a 15-pinhole mp-FXCT imaging system at beamline ARNE-7A at KEK and performed preliminary experiments to investigate its imaging properties using physical phantoms and a non-radioactive I imaging agent. The mp-FXCT system could detect an I concentration of 0.038 mg/ml, the minimum required for in-vivo imaging, at a spatial resolution of about 0.3 mm during a data acquisition time of 90 min, which is less than the time for which anaesthesia is effective and suggests that preclinical molecular imaging is feasible with mp-FXCT.
format	article
author	Tenta Sasaya Naoki Sunaguchi Kazuyuki Hyodo Tsutomu Zeniya Tetsuya Yuasa
author_facet	Tenta Sasaya Naoki Sunaguchi Kazuyuki Hyodo Tsutomu Zeniya Tetsuya Yuasa
author_sort	Tenta Sasaya
title	Multi-pinhole fluorescent x-ray computed tomography for molecular imaging
title_short	Multi-pinhole fluorescent x-ray computed tomography for molecular imaging
title_full	Multi-pinhole fluorescent x-ray computed tomography for molecular imaging
title_fullStr	Multi-pinhole fluorescent x-ray computed tomography for molecular imaging
title_full_unstemmed	Multi-pinhole fluorescent x-ray computed tomography for molecular imaging
title_sort	multi-pinhole fluorescent x-ray computed tomography for molecular imaging
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d988c5ee89eb4340859c19f76b4cc04f
work_keys_str_mv	AT tentasasaya multipinholefluorescentxraycomputedtomographyformolecularimaging AT naokisunaguchi multipinholefluorescentxraycomputedtomographyformolecularimaging AT kazuyukihyodo multipinholefluorescentxraycomputedtomographyformolecularimaging AT tsutomuzeniya multipinholefluorescentxraycomputedtomographyformolecularimaging AT tetsuyayuasa multipinholefluorescentxraycomputedtomographyformolecularimaging
_version_	1718384872299429888

Multi-pinhole fluorescent x-ray computed tomography for molecular imaging

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