Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference

Steffen Naegel, Mark ObermannDepartment of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyAbstract: Migraine is a very common disorder characterized by the combination of typical headache with associated autonomic symptoms and/or the presence of aura. Considerable adva...

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Autores principales:	Steffen Naegel, Mark Obermann
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d98a33ce43c74944b5851239c03d8138
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spelling	oai:doaj.org-article:d98a33ce43c74944b5851239c03d81382021-12-02T01:03:03ZTopiramate in the prevention and treatment of migraine: efficacy, safety and patient preference1176-63281178-2021https://doaj.org/article/d98a33ce43c74944b5851239c03d81382009-12-01T00:00:00Zhttp://www.dovepress.com/topiramate-in-the-prevention-and-treatment-of-migraine-efficacy-safety-a3874https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Steffen Naegel, Mark ObermannDepartment of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyAbstract: Migraine is a very common disorder characterized by the combination of typical headache with associated autonomic symptoms and/or the presence of aura. Considerable advances have been made in recent years to understand the pathophysiology of migraine, which has led to improved treatment options for the acute migraine attack as well as migraine prophylaxis. Unfortunately, preventive treatment is often insufficient to decrease migraine frequency substantially or is not well tolerated. Topiramate is an antipileptic drug with a complex mode of action which has proven its efficacy and safety in the prophylactic treatment of episodic migraine in a number of randomized controlled clinical trials. Topiramate is also effective in treating patients with chronic migraine. It has little pharmacological interaction with other drugs and is generally well tolerated by patients.Keywords: migraine, antiepileptic drugs, topiramate Steffen NaegelMark ObermannDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 17-28 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Steffen Naegel Mark Obermann Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference
description	Steffen Naegel, Mark ObermannDepartment of Neurology, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, GermanyAbstract: Migraine is a very common disorder characterized by the combination of typical headache with associated autonomic symptoms and/or the presence of aura. Considerable advances have been made in recent years to understand the pathophysiology of migraine, which has led to improved treatment options for the acute migraine attack as well as migraine prophylaxis. Unfortunately, preventive treatment is often insufficient to decrease migraine frequency substantially or is not well tolerated. Topiramate is an antipileptic drug with a complex mode of action which has proven its efficacy and safety in the prophylactic treatment of episodic migraine in a number of randomized controlled clinical trials. Topiramate is also effective in treating patients with chronic migraine. It has little pharmacological interaction with other drugs and is generally well tolerated by patients.Keywords: migraine, antiepileptic drugs, topiramate
format	article
author	Steffen Naegel Mark Obermann
author_facet	Steffen Naegel Mark Obermann
author_sort	Steffen Naegel
title	Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference
title_short	Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference
title_full	Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference
title_fullStr	Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference
title_full_unstemmed	Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference
title_sort	topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/d98a33ce43c74944b5851239c03d8138
work_keys_str_mv	AT steffennaegel topiramateinthepreventionandtreatmentofmigraineefficacysafetyandpatientpreference AT markobermann topiramateinthepreventionandtreatmentofmigraineefficacysafetyandpatientpreference
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Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference

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