High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells

He Tian,1 Xing Li,2 Wenli Jiang,3 Cuiting Lv,3 Weizhang Sun,4 Caiguo Huang,3 Ruohua Chen,51Department of Pediatrics of Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; 2Department of Gynecology and Obstetrics of Changhai Hospital, Second Military M...

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Autores principales:	Tian H, Li X, Jiang W, Lv C, Sun W, Huang C, Chen R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	AKR1C1 migration NCI-H446 proliferation SCLC. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d98bc22f5d1b4f669fe3df770af822e1
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spelling	oai:doaj.org-article:d98bc22f5d1b4f669fe3df770af822e12021-12-02T00:30:40ZHigh expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells1179-2728https://doaj.org/article/d98bc22f5d1b4f669fe3df770af822e12016-05-01T00:00:00Zhttps://www.dovepress.com/high-expression-of-akr1c1-is-associated-with-proliferation-and-migrati-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728He Tian,1 Xing Li,2 Wenli Jiang,3 Cuiting Lv,3 Weizhang Sun,4 Caiguo Huang,3 Ruohua Chen,51Department of Pediatrics of Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; 2Department of Gynecology and Obstetrics of Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; 3Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, People's Republic of China; 4PET Center, Chengdu Military Command Region General Hospital, Chengdu, People's Republic of China; 5VIP Clinic of Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China Abstract: AKR1C1 is a member of the AKR1C family, which not only plays an important role in hormone metabolism but is believed to be involved in carcinogen metabolism. Our previous study demonstrated that AKR1C1 was highly expressed in lung tumor tissues as compared with the tumor-adjacent tissues. Small-cell lung cancer (SCLC) is a special type of lung cancer. Surgical treatment of SCLC is usually difficult due to the high degree of malignancy and early metastasis, and difficulty in obtaining clinical specimens. There is not much basic or clinical research on SCLC in the People's Republic of China even in recent years. To investigate the mechanism of AKR1C1 in the pathogenesis of SCLC, the present study used H446 cell line to see whether AKR1C1 could affect the proliferation or migration of SCLC cells, and used a lentivirus to build the AKR1C1 overexpression and under-expression cell lines. The results indicated that AKR1C1 was an important inducement in the proliferation and migration of H446 cells. AKR1C1 promoted cell proliferation and played a vital role in the migration of SCLC cells. These results were also verified in nude mice in vivo. In conclusion, AKR1C1 plays an important role in the development and progression of SCLC and may represent an independent biomarker for assessment of the primary prognosis and therapy of SCLC. Keywords: AKR1C1, migration, NCI-H446, proliferation, small-cell lung cancer (SCLC) Tian HLi XJiang WLv CSun WHuang CChen RDove Medical PressarticleAKR1C1migrationNCI-H446proliferationSCLC.Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 53-61 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	AKR1C1 migration NCI-H446 proliferation SCLC. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	AKR1C1 migration NCI-H446 proliferation SCLC. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Tian H Li X Jiang W Lv C Sun W Huang C Chen R High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells
description	He Tian,1 Xing Li,2 Wenli Jiang,3 Cuiting Lv,3 Weizhang Sun,4 Caiguo Huang,3 Ruohua Chen,51Department of Pediatrics of Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; 2Department of Gynecology and Obstetrics of Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; 3Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, People's Republic of China; 4PET Center, Chengdu Military Command Region General Hospital, Chengdu, People's Republic of China; 5VIP Clinic of Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China Abstract: AKR1C1 is a member of the AKR1C family, which not only plays an important role in hormone metabolism but is believed to be involved in carcinogen metabolism. Our previous study demonstrated that AKR1C1 was highly expressed in lung tumor tissues as compared with the tumor-adjacent tissues. Small-cell lung cancer (SCLC) is a special type of lung cancer. Surgical treatment of SCLC is usually difficult due to the high degree of malignancy and early metastasis, and difficulty in obtaining clinical specimens. There is not much basic or clinical research on SCLC in the People's Republic of China even in recent years. To investigate the mechanism of AKR1C1 in the pathogenesis of SCLC, the present study used H446 cell line to see whether AKR1C1 could affect the proliferation or migration of SCLC cells, and used a lentivirus to build the AKR1C1 overexpression and under-expression cell lines. The results indicated that AKR1C1 was an important inducement in the proliferation and migration of H446 cells. AKR1C1 promoted cell proliferation and played a vital role in the migration of SCLC cells. These results were also verified in nude mice in vivo. In conclusion, AKR1C1 plays an important role in the development and progression of SCLC and may represent an independent biomarker for assessment of the primary prognosis and therapy of SCLC. Keywords: AKR1C1, migration, NCI-H446, proliferation, small-cell lung cancer (SCLC)
format	article
author	Tian H Li X Jiang W Lv C Sun W Huang C Chen R
author_facet	Tian H Li X Jiang W Lv C Sun W Huang C Chen R
author_sort	Tian H
title	High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells
title_short	High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells
title_full	High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells
title_fullStr	High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells
title_full_unstemmed	High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells
title_sort	high expression of akr1c1 is associated with proliferation and migration of small-cell lung cancer cells
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/d98bc22f5d1b4f669fe3df770af822e1
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High expression of AKR1C1 is associated with proliferation and migration of small-cell lung cancer cells

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