Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel

A mutation in Shugoshin-1 causes the Chronic Atrial and Intestinal Dysrhythmia (CAID) Syndrome, but the underlying mechanisms are unknown. Here, the authors show that Shugoshin-1 controls cardiac pacemaker activity by interacting with HCN4 to enhance its cell-surface expression, and that the CAID-Sy...

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Autores principales:	Donghai Liu, Andrew Taehun Song, Xiaoyan Qi, Patrick Piet van Vliet, Jiening Xiao, Feng Xiong, Gregor Andelfinger, Stanley Nattel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d98ddf71fbdb43a688a704b3014cfe3c
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spelling	oai:doaj.org-article:d98ddf71fbdb43a688a704b3014cfe3c2021-12-02T14:29:13ZCohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel10.1038/s41467-021-22737-52041-1723https://doaj.org/article/d98ddf71fbdb43a688a704b3014cfe3c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22737-5https://doaj.org/toc/2041-1723A mutation in Shugoshin-1 causes the Chronic Atrial and Intestinal Dysrhythmia (CAID) Syndrome, but the underlying mechanisms are unknown. Here, the authors show that Shugoshin-1 controls cardiac pacemaker activity by interacting with HCN4 to enhance its cell-surface expression, and that the CAID-Syndrome mutation disrupts cardiac pacemaking by interfering with this important non-canonical interaction.Donghai LiuAndrew Taehun SongXiaoyan QiPatrick Piet van VlietJiening XiaoFeng XiongGregor AndelfingerStanley NattelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Donghai Liu Andrew Taehun Song Xiaoyan Qi Patrick Piet van Vliet Jiening Xiao Feng Xiong Gregor Andelfinger Stanley Nattel Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel
description	A mutation in Shugoshin-1 causes the Chronic Atrial and Intestinal Dysrhythmia (CAID) Syndrome, but the underlying mechanisms are unknown. Here, the authors show that Shugoshin-1 controls cardiac pacemaker activity by interacting with HCN4 to enhance its cell-surface expression, and that the CAID-Syndrome mutation disrupts cardiac pacemaking by interfering with this important non-canonical interaction.
format	article
author	Donghai Liu Andrew Taehun Song Xiaoyan Qi Patrick Piet van Vliet Jiening Xiao Feng Xiong Gregor Andelfinger Stanley Nattel
author_facet	Donghai Liu Andrew Taehun Song Xiaoyan Qi Patrick Piet van Vliet Jiening Xiao Feng Xiong Gregor Andelfinger Stanley Nattel
author_sort	Donghai Liu
title	Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel
title_short	Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel
title_full	Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel
title_fullStr	Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel
title_full_unstemmed	Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel
title_sort	cohesin-protein shugoshin-1 controls cardiac automaticity via hcn4 pacemaker channel
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d98ddf71fbdb43a688a704b3014cfe3c
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Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel

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