The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease

Jing Yan,1,* Chengye Hou,1,2,* Ying Liang1 1National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China; 2Liaoning Province Demobilized Soldiers Kangning...

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Autores principales:	Yan J, Hou C, Liang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Schizophrenia NAFLD risk risk factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d9921709ea3c4ab2ab2c34032376e28a
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spelling	oai:doaj.org-article:d9921709ea3c4ab2ab2c34032376e28a2021-12-02T00:48:35ZThe prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease1178-2021https://doaj.org/article/d9921709ea3c4ab2ab2c34032376e28a2017-06-01T00:00:00Zhttps://www.dovepress.com/the-prevalence-and-risk-factors-of-young-male-schizophrenics-with-non--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jing Yan,1,* Chengye Hou,1,2,* Ying Liang1 1National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China; 2Liaoning Province Demobilized Soldiers Kangning Hospital, Huludao, China *These authors contributed equally to this work Objective: In this study, we compared the prevalence rate of non-alcoholic fatty liver disease (NAFLD) between young males with schizophrenia and the general young males as the control group, and we also investigated the risk factors of NAFLD in young males with schizophrenia.Materials and methods: This is a large cross-sectional study consisting of the study group and parallel control group. The study group comprises 202 cases of young males with schizophrenia recruited from Liaoning province Demobilized Soldiers Kangning Hospital, and 149 healthy young males were recruited as the control group. The clinical evaluation included Positive and Negative Syndrome Scale (PANSS), basic information, disease-related information, and physical examination information. The laboratory tests included fasting blood glucose, total cholesterol, triglyceride, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). The physical examination included liver ultrasonography.Results: No statistical difference was observed between the study and control groups regarding age (30.5±3.9 vs 30.7±3.6), body mass index (BMI), blood pressure, fasting glucose level, and total cholesterol. NAFLD was observed in both the study and control groups. The prevalence of NAFLD was 49.5% (100/202) in the study group, and 20.1% (30/149) in the control group. The study group was further divided into NAFLD group and non-NAFLD group. There were significant differences in medication combination, drug dosage, negative factor score in PANSS (14.1±4.0 vs 12.7±4.5), BMI, fasting glucose level, total cholesterol, triglyceride, ALT, and AST between NAFLD group and non-NAFLD group. According to the results of the multiple-factor analysis, the onset of NAFLD among young males with schizophrenia was significantly correlated with the following factors: triglyceride, BMI, medication combination, drug dosage, and negative factor score in PANSS.Conclusion: The prevalence of NAFLD in the study group was significantly higher than that in the control group. Multivariate analysis indicated that, triglyceride, BMI, medication combination, drug dosage, and negative factor score in PANSS were significantly related to NAFLD in patients with schizophrenia. Keywords: schizophrenia, NAFLD, risk, risk factors, maleYan JHou CLiang YDove Medical PressarticleSchizophreniaNAFLDriskrisk factorsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1493-1498 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Schizophrenia NAFLD risk risk factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Schizophrenia NAFLD risk risk factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yan J Hou C Liang Y The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease
description	Jing Yan,1,* Chengye Hou,1,2,* Ying Liang1 1National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China; 2Liaoning Province Demobilized Soldiers Kangning Hospital, Huludao, China *These authors contributed equally to this work Objective: In this study, we compared the prevalence rate of non-alcoholic fatty liver disease (NAFLD) between young males with schizophrenia and the general young males as the control group, and we also investigated the risk factors of NAFLD in young males with schizophrenia.Materials and methods: This is a large cross-sectional study consisting of the study group and parallel control group. The study group comprises 202 cases of young males with schizophrenia recruited from Liaoning province Demobilized Soldiers Kangning Hospital, and 149 healthy young males were recruited as the control group. The clinical evaluation included Positive and Negative Syndrome Scale (PANSS), basic information, disease-related information, and physical examination information. The laboratory tests included fasting blood glucose, total cholesterol, triglyceride, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). The physical examination included liver ultrasonography.Results: No statistical difference was observed between the study and control groups regarding age (30.5±3.9 vs 30.7±3.6), body mass index (BMI), blood pressure, fasting glucose level, and total cholesterol. NAFLD was observed in both the study and control groups. The prevalence of NAFLD was 49.5% (100/202) in the study group, and 20.1% (30/149) in the control group. The study group was further divided into NAFLD group and non-NAFLD group. There were significant differences in medication combination, drug dosage, negative factor score in PANSS (14.1±4.0 vs 12.7±4.5), BMI, fasting glucose level, total cholesterol, triglyceride, ALT, and AST between NAFLD group and non-NAFLD group. According to the results of the multiple-factor analysis, the onset of NAFLD among young males with schizophrenia was significantly correlated with the following factors: triglyceride, BMI, medication combination, drug dosage, and negative factor score in PANSS.Conclusion: The prevalence of NAFLD in the study group was significantly higher than that in the control group. Multivariate analysis indicated that, triglyceride, BMI, medication combination, drug dosage, and negative factor score in PANSS were significantly related to NAFLD in patients with schizophrenia. Keywords: schizophrenia, NAFLD, risk, risk factors, male
format	article
author	Yan J Hou C Liang Y
author_facet	Yan J Hou C Liang Y
author_sort	Yan J
title	The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease
title_short	The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease
title_full	The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease
title_fullStr	The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease
title_full_unstemmed	The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease
title_sort	prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/d9921709ea3c4ab2ab2c34032376e28a
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The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease

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