Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease

Abstract This study investigated the relationships among plasma biomarkers, regional brain atrophy, and clinical symptoms in patients with Alzheimer’s disease (AD; n = 177), mild cognitive impairment (MCI; N = 60) and controls (n = 108). The Mini-Mental Status Examination (MMSE), Clinical Dementia R...

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Autores principales:	Jung-Lung Hsu, Wei-Ju Lee, Yi-Chu Liao, Jiing-Feng Lirng, Shuu-Jiun Wang, Jong-Ling Fuh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d99495a9982945c99a4047207fbf8b9d
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spelling	oai:doaj.org-article:d99495a9982945c99a4047207fbf8b9d2021-12-02T16:06:19ZPlasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease10.1038/s41598-017-05390-12045-2322https://doaj.org/article/d99495a9982945c99a4047207fbf8b9d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05390-1https://doaj.org/toc/2045-2322Abstract This study investigated the relationships among plasma biomarkers, regional brain atrophy, and clinical symptoms in patients with Alzheimer’s disease (AD; n = 177), mild cognitive impairment (MCI; N = 60) and controls (n = 108). The Mini-Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), and Neuropsychiatric Inventory (NPI) subscales were administered to subjects. Magnetic resonance imaging was performed and medial temporal atrophy (MTA) and posterior atrophy (PA) were assessed visually. We examined associations among cognition, NPI score, plasma β-amyloid (Aβ) and clusterin levels, and regional brain atrophy in patients with AD by regression analysis. The mean MTA score was associated with the plasma Aβ1-42/Aβ1-40 ratio (r = 0.38, p = 0.01) and with MMSE scores (r = 0.43, p < 0.01). The plasma clusterin level was correlated with CDR sum of box and right-side PA scores (r = 0.28, p = 0.01 and r = 0.30, p = 0.03, respectively). Right-side PA scores were correlated significantly with NPI agitation/aggression (r = 0.30, p = 0.03) subscale scores. In conclusion, the plasma ratio of Aβ1-42/Aβ1-40 and clusterin level may be associated with different patterns of regional brain atrophy, which in turn may account for the clinical symptoms in patients with AD.Jung-Lung HsuWei-Ju LeeYi-Chu LiaoJiing-Feng LirngShuu-Jiun WangJong-Ling FuhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jung-Lung Hsu Wei-Ju Lee Yi-Chu Liao Jiing-Feng Lirng Shuu-Jiun Wang Jong-Ling Fuh Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease
description	Abstract This study investigated the relationships among plasma biomarkers, regional brain atrophy, and clinical symptoms in patients with Alzheimer’s disease (AD; n = 177), mild cognitive impairment (MCI; N = 60) and controls (n = 108). The Mini-Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), and Neuropsychiatric Inventory (NPI) subscales were administered to subjects. Magnetic resonance imaging was performed and medial temporal atrophy (MTA) and posterior atrophy (PA) were assessed visually. We examined associations among cognition, NPI score, plasma β-amyloid (Aβ) and clusterin levels, and regional brain atrophy in patients with AD by regression analysis. The mean MTA score was associated with the plasma Aβ1-42/Aβ1-40 ratio (r = 0.38, p = 0.01) and with MMSE scores (r = 0.43, p < 0.01). The plasma clusterin level was correlated with CDR sum of box and right-side PA scores (r = 0.28, p = 0.01 and r = 0.30, p = 0.03, respectively). Right-side PA scores were correlated significantly with NPI agitation/aggression (r = 0.30, p = 0.03) subscale scores. In conclusion, the plasma ratio of Aβ1-42/Aβ1-40 and clusterin level may be associated with different patterns of regional brain atrophy, which in turn may account for the clinical symptoms in patients with AD.
format	article
author	Jung-Lung Hsu Wei-Ju Lee Yi-Chu Liao Jiing-Feng Lirng Shuu-Jiun Wang Jong-Ling Fuh
author_facet	Jung-Lung Hsu Wei-Ju Lee Yi-Chu Liao Jiing-Feng Lirng Shuu-Jiun Wang Jong-Ling Fuh
author_sort	Jung-Lung Hsu
title	Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease
title_short	Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease
title_full	Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease
title_fullStr	Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease
title_full_unstemmed	Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease
title_sort	plasma biomarkers are associated with agitation and regional brain atrophy in alzheimer’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d99495a9982945c99a4047207fbf8b9d
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_version_	1718385058927083520

Plasma biomarkers are associated with agitation and regional brain atrophy in Alzheimer’s disease

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