Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.

Nuclear receptor-mediated signaling via RARs and PPARδ is involved in the regulation of skin homeostasis. Moreover, activation of both RAR and PPARδ was shown to alter skin inflammation. Endogenous all-trans retinoic acid (ATRA) can activate both receptors depending on specific transport proteins: F...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Janine Gericke, Jan Ittensohn, Johanna Mihály, Sandrine Dubrac, Ralph Rühl
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d99614339a384b1ebd01177f7207c1d3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d99614339a384b1ebd01177f7207c1d3
record_format	dspace
spelling	oai:doaj.org-article:d99614339a384b1ebd01177f7207c1d32021-11-18T08:59:27ZAllergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.1932-620310.1371/journal.pone.0071244https://doaj.org/article/d99614339a384b1ebd01177f7207c1d32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977003/?tool=EBIhttps://doaj.org/toc/1932-6203Nuclear receptor-mediated signaling via RARs and PPARδ is involved in the regulation of skin homeostasis. Moreover, activation of both RAR and PPARδ was shown to alter skin inflammation. Endogenous all-trans retinoic acid (ATRA) can activate both receptors depending on specific transport proteins: Fabp5 initiates PPARδ signaling whereas Crabp2 promotes RAR signaling. Repetitive topical applications of ovalbumin (OVA) in combination with intraperitoneal injections of OVA or only intraperitoneal OVA applications were used to induce allergic dermatitis. In our mouse model, expression of IL-4, and Hbegf increased whereas expression of involucrin, Abca12 and Spink5 decreased in inflamed skin, demonstrating altered immune response and epidermal barrier homeostasis. Comprehensive gene expression analysis showed alterations of the cutaneous retinoid metabolism and retinoid-mediated signaling in allergic skin immune response. Notably, ATRA synthesis was increased as indicated by the elevated expression of retinaldehyde dehydrogenases and increased levels of ATRA. Consequently, the expression pattern of genes downstream to RAR was altered. Furthermore, the increased ratio of Fabp5 vs. Crabp2 may indicate an up-regulation of the PPARδ pathway in allergen-induced dermatitis in addition to the altered RAR signaling. Thus, our findings suggest that ATRA levels, RAR-mediated signaling and signaling involved in PPARδ pathways are mainly increased in allergen-induced dermatitis and may contribute to the development and/or maintenance of allergic skin diseases.Janine GerickeJan IttensohnJohanna MihálySandrine DubracRalph RühlPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71244 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Janine Gericke Jan Ittensohn Johanna Mihály Sandrine Dubrac Ralph Rühl Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.
description	Nuclear receptor-mediated signaling via RARs and PPARδ is involved in the regulation of skin homeostasis. Moreover, activation of both RAR and PPARδ was shown to alter skin inflammation. Endogenous all-trans retinoic acid (ATRA) can activate both receptors depending on specific transport proteins: Fabp5 initiates PPARδ signaling whereas Crabp2 promotes RAR signaling. Repetitive topical applications of ovalbumin (OVA) in combination with intraperitoneal injections of OVA or only intraperitoneal OVA applications were used to induce allergic dermatitis. In our mouse model, expression of IL-4, and Hbegf increased whereas expression of involucrin, Abca12 and Spink5 decreased in inflamed skin, demonstrating altered immune response and epidermal barrier homeostasis. Comprehensive gene expression analysis showed alterations of the cutaneous retinoid metabolism and retinoid-mediated signaling in allergic skin immune response. Notably, ATRA synthesis was increased as indicated by the elevated expression of retinaldehyde dehydrogenases and increased levels of ATRA. Consequently, the expression pattern of genes downstream to RAR was altered. Furthermore, the increased ratio of Fabp5 vs. Crabp2 may indicate an up-regulation of the PPARδ pathway in allergen-induced dermatitis in addition to the altered RAR signaling. Thus, our findings suggest that ATRA levels, RAR-mediated signaling and signaling involved in PPARδ pathways are mainly increased in allergen-induced dermatitis and may contribute to the development and/or maintenance of allergic skin diseases.
format	article
author	Janine Gericke Jan Ittensohn Johanna Mihály Sandrine Dubrac Ralph Rühl
author_facet	Janine Gericke Jan Ittensohn Johanna Mihály Sandrine Dubrac Ralph Rühl
author_sort	Janine Gericke
title	Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.
title_short	Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.
title_full	Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.
title_fullStr	Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.
title_full_unstemmed	Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.
title_sort	allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d99614339a384b1ebd01177f7207c1d3
work_keys_str_mv	AT janinegericke allergeninduceddermatitiscausesalterationsincutaneousretinoidmediatedsignalinginmice AT janittensohn allergeninduceddermatitiscausesalterationsincutaneousretinoidmediatedsignalinginmice AT johannamihaly allergeninduceddermatitiscausesalterationsincutaneousretinoidmediatedsignalinginmice AT sandrinedubrac allergeninduceddermatitiscausesalterationsincutaneousretinoidmediatedsignalinginmice AT ralphruhl allergeninduceddermatitiscausesalterationsincutaneousretinoidmediatedsignalinginmice
_version_	1718421112399855616

Allergen-induced dermatitis causes alterations in cutaneous retinoid-mediated signaling in mice.

Ejemplares similares