Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes

The therapeutic landscape for the treatment of cancer has evolved significantly in recent decades, aided by the development of effective oncology drugs. However, many cancer drugs are often poorly tolerated by the body and in particular the cardiovascular system, causing adverse and sometimes fatal...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mo-Fan Huang, Lon Kai Pang, Yi-Hung Chen, Ruiying Zhao, Dung-Fang Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stem cell disease model induced pluripotency reprogramming differentiation chemotherapy Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d997cfa149d14d118a45b22d671915dd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d997cfa149d14d118a45b22d671915dd
record_format	dspace
spelling	oai:doaj.org-article:d997cfa149d14d118a45b22d671915dd2021-11-25T17:07:35ZCardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes10.3390/cells101128232073-4409https://doaj.org/article/d997cfa149d14d118a45b22d671915dd2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2823https://doaj.org/toc/2073-4409The therapeutic landscape for the treatment of cancer has evolved significantly in recent decades, aided by the development of effective oncology drugs. However, many cancer drugs are often poorly tolerated by the body and in particular the cardiovascular system, causing adverse and sometimes fatal side effects that negate the chemotherapeutic benefits. The prevalence and severity of chemotherapy-induced cardiotoxicity warrants a deeper investigation of the mechanisms and implicating factors in this phenomenon, and a consolidation of scientific efforts to develop mitigating strategies. Aiding these efforts is the emergence of induced pluripotent stem cells (iPSCs) in recent years, which has allowed for the generation of iPSC-derived cardiomyocytes (iPSC-CMs): a human-based, patient-derived, and genetically variable platform that can be applied to the study of chemotherapy-induced cardiotoxicity and beyond. After surveying chemotherapy-induced cardiotoxicity and the associated chemotherapeutic agents, we discuss the use of iPSC-CMs in cardiotoxicity modeling, drug screening, and other potential applications. Improvements to the iPSC-CM platform, such as the development of more adult-like cardiomyocytes and ongoing advances in biotechnology, will only enhance the utility of iPSC-CMs in both basic science and clinical applications.Mo-Fan HuangLon Kai PangYi-Hung ChenRuiying ZhaoDung-Fang LeeMDPI AGarticlestem celldisease modelinduced pluripotencyreprogrammingdifferentiationchemotherapyBiology (General)QH301-705.5ENCells, Vol 10, Iss 2823, p 2823 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stem cell disease model induced pluripotency reprogramming differentiation chemotherapy Biology (General) QH301-705.5
spellingShingle	stem cell disease model induced pluripotency reprogramming differentiation chemotherapy Biology (General) QH301-705.5 Mo-Fan Huang Lon Kai Pang Yi-Hung Chen Ruiying Zhao Dung-Fang Lee Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
description	The therapeutic landscape for the treatment of cancer has evolved significantly in recent decades, aided by the development of effective oncology drugs. However, many cancer drugs are often poorly tolerated by the body and in particular the cardiovascular system, causing adverse and sometimes fatal side effects that negate the chemotherapeutic benefits. The prevalence and severity of chemotherapy-induced cardiotoxicity warrants a deeper investigation of the mechanisms and implicating factors in this phenomenon, and a consolidation of scientific efforts to develop mitigating strategies. Aiding these efforts is the emergence of induced pluripotent stem cells (iPSCs) in recent years, which has allowed for the generation of iPSC-derived cardiomyocytes (iPSC-CMs): a human-based, patient-derived, and genetically variable platform that can be applied to the study of chemotherapy-induced cardiotoxicity and beyond. After surveying chemotherapy-induced cardiotoxicity and the associated chemotherapeutic agents, we discuss the use of iPSC-CMs in cardiotoxicity modeling, drug screening, and other potential applications. Improvements to the iPSC-CM platform, such as the development of more adult-like cardiomyocytes and ongoing advances in biotechnology, will only enhance the utility of iPSC-CMs in both basic science and clinical applications.
format	article
author	Mo-Fan Huang Lon Kai Pang Yi-Hung Chen Ruiying Zhao Dung-Fang Lee
author_facet	Mo-Fan Huang Lon Kai Pang Yi-Hung Chen Ruiying Zhao Dung-Fang Lee
author_sort	Mo-Fan Huang
title	Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
title_short	Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
title_full	Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
title_fullStr	Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
title_full_unstemmed	Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes
title_sort	cardiotoxicity of antineoplastic therapies and applications of induced pluripotent stem cell-derived cardiomyocytes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d997cfa149d14d118a45b22d671915dd
work_keys_str_mv	AT mofanhuang cardiotoxicityofantineoplastictherapiesandapplicationsofinducedpluripotentstemcellderivedcardiomyocytes AT lonkaipang cardiotoxicityofantineoplastictherapiesandapplicationsofinducedpluripotentstemcellderivedcardiomyocytes AT yihungchen cardiotoxicityofantineoplastictherapiesandapplicationsofinducedpluripotentstemcellderivedcardiomyocytes AT ruiyingzhao cardiotoxicityofantineoplastictherapiesandapplicationsofinducedpluripotentstemcellderivedcardiomyocytes AT dungfanglee cardiotoxicityofantineoplastictherapiesandapplicationsofinducedpluripotentstemcellderivedcardiomyocytes
_version_	1718412745326460928

Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Ejemplares similares