IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology

Cytokines are powerful mediators of inflammation. Consequently, their potency is regulated in many ways to protect the host. Several cytokines, including IL-22, have coordinating binding proteins or soluble receptors that bind to the cytokine, block the interaction with the cellular receptor, and th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Lauren A. Zenewicz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	IL-22 IL-22 binding protein cytokines inflammation immune regulation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d99dc9d30f9849c5b8d69b893c6383c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d99dc9d30f9849c5b8d69b893c6383c1
record_format	dspace
spelling	oai:doaj.org-article:d99dc9d30f9849c5b8d69b893c6383c12021-11-16T04:32:12ZIL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology1664-322410.3389/fimmu.2021.766586https://doaj.org/article/d99dc9d30f9849c5b8d69b893c6383c12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.766586/fullhttps://doaj.org/toc/1664-3224Cytokines are powerful mediators of inflammation. Consequently, their potency is regulated in many ways to protect the host. Several cytokines, including IL-22, have coordinating binding proteins or soluble receptors that bind to the cytokine, block the interaction with the cellular receptor, and thus prevent cellular signaling. IL-22 is a critical cytokine in the modulation of tissue responses during inflammation and is highly upregulated in many chronic inflammatory disease patients, including those with psoriasis, rheumatoid arthritis, and inflammatory bowel disease (IBD). In healthy individuals, low levels of IL-22 are secreted by immune cells, mainly in the gastrointestinal (GI) tract. However, much of this IL-22 is likely not biologically active due to the high levels of IL-22 binding protein (IL-22BP) produced by intestinal dendritic cells (DCs). IL-22BP is a soluble receptor homolog that binds to IL-22 with greater affinity than the membrane spanning receptor. Much is known regarding the regulation and function of IL-22 in health and disease. However, less is known about IL-22BP. In this review, we will focus on IL-22BP, including its regulation, role in IL-22 biology and inflammation, and promise as a therapeutic. IL-22 can be protective or pathogenic, depending on the context of inflammation. IL-22BP also has divergent roles. Ongoing and forthcoming studies will expand our knowledge of IL-22BP and IL-22 biology, and suggest that IL-22BP holds promise as a way to regulate IL-22 biology in patients with chronic inflammatory disease.Lauren A. ZenewiczFrontiers Media S.A.articleIL-22IL-22 binding proteincytokinesinflammationimmune regulationImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IL-22 IL-22 binding protein cytokines inflammation immune regulation Immunologic diseases. Allergy RC581-607
spellingShingle	IL-22 IL-22 binding protein cytokines inflammation immune regulation Immunologic diseases. Allergy RC581-607 Lauren A. Zenewicz IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology
description	Cytokines are powerful mediators of inflammation. Consequently, their potency is regulated in many ways to protect the host. Several cytokines, including IL-22, have coordinating binding proteins or soluble receptors that bind to the cytokine, block the interaction with the cellular receptor, and thus prevent cellular signaling. IL-22 is a critical cytokine in the modulation of tissue responses during inflammation and is highly upregulated in many chronic inflammatory disease patients, including those with psoriasis, rheumatoid arthritis, and inflammatory bowel disease (IBD). In healthy individuals, low levels of IL-22 are secreted by immune cells, mainly in the gastrointestinal (GI) tract. However, much of this IL-22 is likely not biologically active due to the high levels of IL-22 binding protein (IL-22BP) produced by intestinal dendritic cells (DCs). IL-22BP is a soluble receptor homolog that binds to IL-22 with greater affinity than the membrane spanning receptor. Much is known regarding the regulation and function of IL-22 in health and disease. However, less is known about IL-22BP. In this review, we will focus on IL-22BP, including its regulation, role in IL-22 biology and inflammation, and promise as a therapeutic. IL-22 can be protective or pathogenic, depending on the context of inflammation. IL-22BP also has divergent roles. Ongoing and forthcoming studies will expand our knowledge of IL-22BP and IL-22 biology, and suggest that IL-22BP holds promise as a way to regulate IL-22 biology in patients with chronic inflammatory disease.
format	article
author	Lauren A. Zenewicz
author_facet	Lauren A. Zenewicz
author_sort	Lauren A. Zenewicz
title	IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology
title_short	IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology
title_full	IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology
title_fullStr	IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology
title_full_unstemmed	IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology
title_sort	il-22 binding protein (il-22bp) in the regulation of il-22 biology
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d99dc9d30f9849c5b8d69b893c6383c1
work_keys_str_mv	AT laurenazenewicz il22bindingproteinil22bpintheregulationofil22biology
_version_	1718426756010999808

IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology

Ejemplares similares