Asymmetric division events promote variability in cell cycle duration in animal cells and Escherichia coli

We know that variations in cell cycle duration between cells naturally occur but the mechanisms are largely unknown. Here, using lineage tracking, hierarchical clustering and Monte Carlo methods, the authors show that large differences in granddaughter cell cycle duration are driven by asymmetric di...

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Autores principales: Ulrich Berge, Daria Bochenek, Ralf Schnabel, Arne Wehling, Timm Schroeder, Tanja Stadler, Ruth Kroschewski
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d99e5c021b4647a79e4a74857f23b574
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Sumario:We know that variations in cell cycle duration between cells naturally occur but the mechanisms are largely unknown. Here, using lineage tracking, hierarchical clustering and Monte Carlo methods, the authors show that large differences in granddaughter cell cycle duration are driven by asymmetric divisions.