A Hypothetical Model Suggesting Some Possible Ways That the Progesterone Receptor May Be Involved in Cancer Proliferation

Cancer and the fetal-placental semi-allograft share certain characteristics, e.g., rapid proliferation, the capacity to invade normal tissue, and, related to the presence of antigens foreign to the host, the need to evade immune surveillance. Many present-day methods to treat cancer use drugs that c...

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Autores principales:	Jerome H. Check, Diane L. Check
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	progesterone receptors progesterone receptor modulators malignant tumors tumor microenvironment cellular immunity natural killer cells Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d9a248a770754804ba6579e34c806d63
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spelling	oai:doaj.org-article:d9a248a770754804ba6579e34c806d632021-11-25T17:55:38ZA Hypothetical Model Suggesting Some Possible Ways That the Progesterone Receptor May Be Involved in Cancer Proliferation10.3390/ijms2222123511422-00671661-6596https://doaj.org/article/d9a248a770754804ba6579e34c806d632021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12351https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cancer and the fetal-placental semi-allograft share certain characteristics, e.g., rapid proliferation, the capacity to invade normal tissue, and, related to the presence of antigens foreign to the host, the need to evade immune surveillance. Many present-day methods to treat cancer use drugs that can block a key molecule that is important for one or more of these characteristics and thus reduce side effects. The ideal molecule would be one that is essential for both the survival of the fetus and malignant tumor, but not needed for normal cells. There is a potential suitable candidate, the progesterone induced blocking factor (PIBF). The parent 90 kilodalton (kDa) form seems to be required for cell-cycle regulation, required by both the fetal-placental unit and malignant tumors. The parent form may be converted to splice variants that help both the fetus and tumors escape immune surveillance, especially in the fetal and tumor microenvironment. Evidence suggests that membrane progesterone receptors are involved in PIBF production, and indeed there has been anecdotal evidence that progesterone receptor antagonists, e.g., mifepristone, can significantly improve longevity and quality of life, with few side effects.Jerome H. CheckDiane L. CheckMDPI AGarticleprogesterone receptorsprogesterone receptor modulatorsmalignant tumorstumor microenvironmentcellular immunitynatural killer cellsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12351, p 12351 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	progesterone receptors progesterone receptor modulators malignant tumors tumor microenvironment cellular immunity natural killer cells Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	progesterone receptors progesterone receptor modulators malignant tumors tumor microenvironment cellular immunity natural killer cells Biology (General) QH301-705.5 Chemistry QD1-999 Jerome H. Check Diane L. Check A Hypothetical Model Suggesting Some Possible Ways That the Progesterone Receptor May Be Involved in Cancer Proliferation
description	Cancer and the fetal-placental semi-allograft share certain characteristics, e.g., rapid proliferation, the capacity to invade normal tissue, and, related to the presence of antigens foreign to the host, the need to evade immune surveillance. Many present-day methods to treat cancer use drugs that can block a key molecule that is important for one or more of these characteristics and thus reduce side effects. The ideal molecule would be one that is essential for both the survival of the fetus and malignant tumor, but not needed for normal cells. There is a potential suitable candidate, the progesterone induced blocking factor (PIBF). The parent 90 kilodalton (kDa) form seems to be required for cell-cycle regulation, required by both the fetal-placental unit and malignant tumors. The parent form may be converted to splice variants that help both the fetus and tumors escape immune surveillance, especially in the fetal and tumor microenvironment. Evidence suggests that membrane progesterone receptors are involved in PIBF production, and indeed there has been anecdotal evidence that progesterone receptor antagonists, e.g., mifepristone, can significantly improve longevity and quality of life, with few side effects.
format	article
author	Jerome H. Check Diane L. Check
author_facet	Jerome H. Check Diane L. Check
author_sort	Jerome H. Check
title	A Hypothetical Model Suggesting Some Possible Ways That the Progesterone Receptor May Be Involved in Cancer Proliferation
title_short	A Hypothetical Model Suggesting Some Possible Ways That the Progesterone Receptor May Be Involved in Cancer Proliferation
title_full	A Hypothetical Model Suggesting Some Possible Ways That the Progesterone Receptor May Be Involved in Cancer Proliferation
title_fullStr	A Hypothetical Model Suggesting Some Possible Ways That the Progesterone Receptor May Be Involved in Cancer Proliferation
title_full_unstemmed	A Hypothetical Model Suggesting Some Possible Ways That the Progesterone Receptor May Be Involved in Cancer Proliferation
title_sort	hypothetical model suggesting some possible ways that the progesterone receptor may be involved in cancer proliferation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d9a248a770754804ba6579e34c806d63
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A Hypothetical Model Suggesting Some Possible Ways That the Progesterone Receptor May Be Involved in Cancer Proliferation

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