Extracellular vesicles as a new hope for diagnosis and therapeutic intervention for hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is the sixth most common cancer with a high mortality rate. Early diagnosis and treatment before tumor progression into an advanced stage is ideal. The current diagnosis of HCC is mainly based on imaging modalities such as ultrasound, computed tomography, and...

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Autores principales:	Natthaphong Nimitrungtawee, Nakarin Inmutto, Siriporn C. Chattipakorn, Nipon Chattipakorn
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Biomarker Diagnosis Exosome Extracellular vesicle HCC miRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d9a5f4ae272a4f9090a7c230c1a73027
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spelling	oai:doaj.org-article:d9a5f4ae272a4f9090a7c230c1a730272021-12-01T04:49:14ZExtracellular vesicles as a new hope for diagnosis and therapeutic intervention for hepatocellular carcinoma2045-763410.1002/cam4.4370https://doaj.org/article/d9a5f4ae272a4f9090a7c230c1a730272021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4370https://doaj.org/toc/2045-7634Abstract Hepatocellular carcinoma (HCC) is the sixth most common cancer with a high mortality rate. Early diagnosis and treatment before tumor progression into an advanced stage is ideal. The current diagnosis of HCC is mainly based on imaging modalities such as ultrasound, computed tomography, and magnetic resonance imaging. These methods have some limitations including diagnosis in the case of very small tumors with atypical imaging patterns. Extracellular vesicles (EVs) are nanosized vesicles which have been shown to act as an important vector for cell‐to‐cell communication. In the past decade, EVs have been investigated with regard to their roles in HCC formation. Since these EVs contain biomolecular cargo such as nucleic acid, lipids, and proteins, it has been proposed that they could be a potential source of tumor biomarkers and a vector for therapeutic cargo. In this review, reports on the roles of HCC‐derived EVs in tumorigenesis, and clinical investigations using circulating EVs as a biomarker for HCC and their potential diagnostic roles have been comprehensively summarized and discussed. In addition, findings from in vitro and in vivo reports investigating the potential roles of EVs as therapeutic interventions are also presented. These findings regarding the potential benefits of EVs will encourage further investigations and may allow us to devise novel strategies using EVs in the early diagnosis as well as for treatment of HCC in the future.Natthaphong NimitrungtaweeNakarin InmuttoSiriporn C. ChattipakornNipon ChattipakornWileyarticleBiomarkerDiagnosisExosomeExtracellular vesicleHCCmiRNANeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8253-8271 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biomarker Diagnosis Exosome Extracellular vesicle HCC miRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Biomarker Diagnosis Exosome Extracellular vesicle HCC miRNA Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Natthaphong Nimitrungtawee Nakarin Inmutto Siriporn C. Chattipakorn Nipon Chattipakorn Extracellular vesicles as a new hope for diagnosis and therapeutic intervention for hepatocellular carcinoma
description	Abstract Hepatocellular carcinoma (HCC) is the sixth most common cancer with a high mortality rate. Early diagnosis and treatment before tumor progression into an advanced stage is ideal. The current diagnosis of HCC is mainly based on imaging modalities such as ultrasound, computed tomography, and magnetic resonance imaging. These methods have some limitations including diagnosis in the case of very small tumors with atypical imaging patterns. Extracellular vesicles (EVs) are nanosized vesicles which have been shown to act as an important vector for cell‐to‐cell communication. In the past decade, EVs have been investigated with regard to their roles in HCC formation. Since these EVs contain biomolecular cargo such as nucleic acid, lipids, and proteins, it has been proposed that they could be a potential source of tumor biomarkers and a vector for therapeutic cargo. In this review, reports on the roles of HCC‐derived EVs in tumorigenesis, and clinical investigations using circulating EVs as a biomarker for HCC and their potential diagnostic roles have been comprehensively summarized and discussed. In addition, findings from in vitro and in vivo reports investigating the potential roles of EVs as therapeutic interventions are also presented. These findings regarding the potential benefits of EVs will encourage further investigations and may allow us to devise novel strategies using EVs in the early diagnosis as well as for treatment of HCC in the future.
format	article
author	Natthaphong Nimitrungtawee Nakarin Inmutto Siriporn C. Chattipakorn Nipon Chattipakorn
author_facet	Natthaphong Nimitrungtawee Nakarin Inmutto Siriporn C. Chattipakorn Nipon Chattipakorn
author_sort	Natthaphong Nimitrungtawee
title	Extracellular vesicles as a new hope for diagnosis and therapeutic intervention for hepatocellular carcinoma
title_short	Extracellular vesicles as a new hope for diagnosis and therapeutic intervention for hepatocellular carcinoma
title_full	Extracellular vesicles as a new hope for diagnosis and therapeutic intervention for hepatocellular carcinoma
title_fullStr	Extracellular vesicles as a new hope for diagnosis and therapeutic intervention for hepatocellular carcinoma
title_full_unstemmed	Extracellular vesicles as a new hope for diagnosis and therapeutic intervention for hepatocellular carcinoma
title_sort	extracellular vesicles as a new hope for diagnosis and therapeutic intervention for hepatocellular carcinoma
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/d9a5f4ae272a4f9090a7c230c1a73027
work_keys_str_mv	AT natthaphongnimitrungtawee extracellularvesiclesasanewhopefordiagnosisandtherapeuticinterventionforhepatocellularcarcinoma AT nakarininmutto extracellularvesiclesasanewhopefordiagnosisandtherapeuticinterventionforhepatocellularcarcinoma AT siriporncchattipakorn extracellularvesiclesasanewhopefordiagnosisandtherapeuticinterventionforhepatocellularcarcinoma AT niponchattipakorn extracellularvesiclesasanewhopefordiagnosisandtherapeuticinterventionforhepatocellularcarcinoma
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Extracellular vesicles as a new hope for diagnosis and therapeutic intervention for hepatocellular carcinoma

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