Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis

Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis

Autoimmune pulmonary alveolar proteinosis (aPAP) is a complex lung disease caused by abnormal surfactant homeostasis. Here, the authors carry out a genome-wide association study of aPAP in a Japanese cohort, finding variants in the MHC and suggesting predisposition to abnormal antibody production.

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Autores principales: Saori Sakaue, Etsuro Yamaguchi, Yoshikazu Inoue, Meiko Takahashi, Jun Hirata, Ken Suzuki, Satoru Ito, Toru Arai, Masaki Hirose, Yoshinori Tanino, Takefumi Nikaido, Toshio Ichiwata, Shinya Ohkouchi, Taizou Hirano, Toshinori Takada, Satoru Miyawaki, Shogo Dofuku, Yuichi Maeda, Takuro Nii, Toshihiro Kishikawa, Kotaro Ogawa, Tatsuo Masuda, Kenichi Yamamoto, Kyuto Sonehara, Ryushi Tazawa, Konosuke Morimoto, Masahiro Takaki, Satoshi Konno, Masaru Suzuki, Keisuke Tomii, Atsushi Nakagawa, Tomohiro Handa, Kiminobu Tanizawa, Haruyuki Ishii, Manabu Ishida, Toshiyuki Kato, Naoya Takeda, Koshi Yokomura, Takashi Matsui, Masaki Watanabe, Hiromasa Inoue, Kazuyoshi Imaizumi, Yasuhiro Goto, Hiroshi Kida, Tomoyuki Fujisawa, Takafumi Suda, Takashi Yamada, Yasuomi Satake, Hidenori Ibata, Nobuyuki Hizawa, Hideki Mochizuki, Atsushi Kumanogoh, Fumihiko Matsuda, Koh Nakata, Tomomitsu Hirota, Mayumi Tamari, Yukinori Okada
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d9a62f084a8e4179916af621aeb86739
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spelling oai:doaj.org-article:d9a62f084a8e4179916af621aeb867392021-12-02T12:11:51ZGenetic determinants of risk in autoimmune pulmonary alveolar proteinosis10.1038/s41467-021-21011-y2041-1723https://doaj.org/article/d9a62f084a8e4179916af621aeb867392021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21011-yhttps://doaj.org/toc/2041-1723Autoimmune pulmonary alveolar proteinosis (aPAP) is a complex lung disease caused by abnormal surfactant homeostasis. Here, the authors carry out a genome-wide association study of aPAP in a Japanese cohort, finding variants in the MHC and suggesting predisposition to abnormal antibody production.Saori SakaueEtsuro YamaguchiYoshikazu InoueMeiko TakahashiJun HirataKen SuzukiSatoru ItoToru AraiMasaki HiroseYoshinori TaninoTakefumi NikaidoToshio IchiwataShinya OhkouchiTaizou HiranoToshinori TakadaSatoru MiyawakiShogo DofukuYuichi MaedaTakuro NiiToshihiro KishikawaKotaro OgawaTatsuo MasudaKenichi YamamotoKyuto SoneharaRyushi TazawaKonosuke MorimotoMasahiro TakakiSatoshi KonnoMasaru SuzukiKeisuke TomiiAtsushi NakagawaTomohiro HandaKiminobu TanizawaHaruyuki IshiiManabu IshidaToshiyuki KatoNaoya TakedaKoshi YokomuraTakashi MatsuiMasaki WatanabeHiromasa InoueKazuyoshi ImaizumiYasuhiro GotoHiroshi KidaTomoyuki FujisawaTakafumi SudaTakashi YamadaYasuomi SatakeHidenori IbataNobuyuki HizawaHideki MochizukiAtsushi KumanogohFumihiko MatsudaKoh NakataTomomitsu HirotaMayumi TamariYukinori OkadaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Saori Sakaue
Etsuro Yamaguchi
Yoshikazu Inoue
Meiko Takahashi
Jun Hirata
Ken Suzuki
Satoru Ito
Toru Arai
Masaki Hirose
Yoshinori Tanino
Takefumi Nikaido
Toshio Ichiwata
Shinya Ohkouchi
Taizou Hirano
Toshinori Takada
Satoru Miyawaki
Shogo Dofuku
Yuichi Maeda
Takuro Nii
Toshihiro Kishikawa
Kotaro Ogawa
Tatsuo Masuda
Kenichi Yamamoto
Kyuto Sonehara
Ryushi Tazawa
Konosuke Morimoto
Masahiro Takaki
Satoshi Konno
Masaru Suzuki
Keisuke Tomii
Atsushi Nakagawa
Tomohiro Handa
Kiminobu Tanizawa
Haruyuki Ishii
Manabu Ishida
Toshiyuki Kato
Naoya Takeda
Koshi Yokomura
Takashi Matsui
Masaki Watanabe
Hiromasa Inoue
Kazuyoshi Imaizumi
Yasuhiro Goto
Hiroshi Kida
Tomoyuki Fujisawa
Takafumi Suda
Takashi Yamada
Yasuomi Satake
Hidenori Ibata
Nobuyuki Hizawa
Hideki Mochizuki
Atsushi Kumanogoh
Fumihiko Matsuda
Koh Nakata
Tomomitsu Hirota
Mayumi Tamari
Yukinori Okada
Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis
description Autoimmune pulmonary alveolar proteinosis (aPAP) is a complex lung disease caused by abnormal surfactant homeostasis. Here, the authors carry out a genome-wide association study of aPAP in a Japanese cohort, finding variants in the MHC and suggesting predisposition to abnormal antibody production.
format article
author Saori Sakaue
Etsuro Yamaguchi
Yoshikazu Inoue
Meiko Takahashi
Jun Hirata
Ken Suzuki
Satoru Ito
Toru Arai
Masaki Hirose
Yoshinori Tanino
Takefumi Nikaido
Toshio Ichiwata
Shinya Ohkouchi
Taizou Hirano
Toshinori Takada
Satoru Miyawaki
Shogo Dofuku
Yuichi Maeda
Takuro Nii
Toshihiro Kishikawa
Kotaro Ogawa
Tatsuo Masuda
Kenichi Yamamoto
Kyuto Sonehara
Ryushi Tazawa
Konosuke Morimoto
Masahiro Takaki
Satoshi Konno
Masaru Suzuki
Keisuke Tomii
Atsushi Nakagawa
Tomohiro Handa
Kiminobu Tanizawa
Haruyuki Ishii
Manabu Ishida
Toshiyuki Kato
Naoya Takeda
Koshi Yokomura
Takashi Matsui
Masaki Watanabe
Hiromasa Inoue
Kazuyoshi Imaizumi
Yasuhiro Goto
Hiroshi Kida
Tomoyuki Fujisawa
Takafumi Suda
Takashi Yamada
Yasuomi Satake
Hidenori Ibata
Nobuyuki Hizawa
Hideki Mochizuki
Atsushi Kumanogoh
Fumihiko Matsuda
Koh Nakata
Tomomitsu Hirota
Mayumi Tamari
Yukinori Okada
author_facet Saori Sakaue
Etsuro Yamaguchi
Yoshikazu Inoue
Meiko Takahashi
Jun Hirata
Ken Suzuki
Satoru Ito
Toru Arai
Masaki Hirose
Yoshinori Tanino
Takefumi Nikaido
Toshio Ichiwata
Shinya Ohkouchi
Taizou Hirano
Toshinori Takada
Satoru Miyawaki
Shogo Dofuku
Yuichi Maeda
Takuro Nii
Toshihiro Kishikawa
Kotaro Ogawa
Tatsuo Masuda
Kenichi Yamamoto
Kyuto Sonehara
Ryushi Tazawa
Konosuke Morimoto
Masahiro Takaki
Satoshi Konno
Masaru Suzuki
Keisuke Tomii
Atsushi Nakagawa
Tomohiro Handa
Kiminobu Tanizawa
Haruyuki Ishii
Manabu Ishida
Toshiyuki Kato
Naoya Takeda
Koshi Yokomura
Takashi Matsui
Masaki Watanabe
Hiromasa Inoue
Kazuyoshi Imaizumi
Yasuhiro Goto
Hiroshi Kida
Tomoyuki Fujisawa
Takafumi Suda
Takashi Yamada
Yasuomi Satake
Hidenori Ibata
Nobuyuki Hizawa
Hideki Mochizuki
Atsushi Kumanogoh
Fumihiko Matsuda
Koh Nakata
Tomomitsu Hirota
Mayumi Tamari
Yukinori Okada
author_sort Saori Sakaue
title Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis
title_short Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis
title_full Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis
title_fullStr Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis
title_full_unstemmed Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis
title_sort genetic determinants of risk in autoimmune pulmonary alveolar proteinosis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d9a62f084a8e4179916af621aeb86739
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