Kinome Expansion in the <named-content content-type="genus-species">Fusarium oxysporum</named-content> Species Complex Driven by Accessory Chromosomes

ABSTRACT The Fusarium oxysporum species complex (FOSC) is a group of soilborne pathogens causing severe disease in more than 100 plant hosts, while individual strains exhibit strong host specificity. Both chromosome transfer and comparative genomics experiments have demonstrated that lineage-specifi...

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Autores principales:	Gregory A. DeIulio, Li Guo, Yong Zhang, Jonathan M. Goldberg, H. Corby Kistler, Li-Jun Ma
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	Fusarium oxysporum species complex TOR kinase accessory chromosome histidine kinase kinome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d9a664ae35754c9e924e404b9e2e71bf
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spelling	oai:doaj.org-article:d9a664ae35754c9e924e404b9e2e71bf2021-11-15T15:24:23ZKinome Expansion in the <named-content content-type="genus-species">Fusarium oxysporum</named-content> Species Complex Driven by Accessory Chromosomes10.1128/mSphere.00231-182379-5042https://doaj.org/article/d9a664ae35754c9e924e404b9e2e71bf2018-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00231-18https://doaj.org/toc/2379-5042ABSTRACT The Fusarium oxysporum species complex (FOSC) is a group of soilborne pathogens causing severe disease in more than 100 plant hosts, while individual strains exhibit strong host specificity. Both chromosome transfer and comparative genomics experiments have demonstrated that lineage-specific (LS) chromosomes contribute to the host-specific pathogenicity. However, little is known about the functional importance of genes encoded in these LS chromosomes. Focusing on signaling transduction, this study compared the kinomes of 12 F. oxysporum isolates, including both plant and human pathogens and 1 nonpathogenic biocontrol strain, with 7 additional publicly available ascomycete genomes. Overall, F. oxysporum kinomes are the largest, facilitated in part by the acquisitions of the LS chromosomes. The comparative study identified 99 kinases that are present in almost all examined fungal genomes, forming the core signaling network of ascomycete fungi. Compared to the conserved ascomycete kinome, the expansion of the F. oxysporum kinome occurs in several kinase families such as histidine kinases that are involved in environmental signal sensing and target of rapamycin (TOR) kinase that mediates cellular responses. Comparative kinome analysis suggests a convergent evolution that shapes individual F. oxysporum isolates with an enhanced and unique capacity for environmental perception and associated downstream responses. IMPORTANCE Isolates of Fusarium oxysporum are adapted to survive a wide range of host and nonhost conditions. In addition, F. oxysporum was recently recognized as the top emerging opportunistic fungal pathogen infecting immunocompromised humans. The sensory and response networks of these fungi undoubtedly play a fundamental role in establishing the adaptability of this group. We have examined the kinomes of 12 F. oxysporum isolates and highlighted kinase families that distinguish F. oxysporum from other fungi, as well as different isolates from one another. The amplification of kinases involved in environmental signal relay and regulating downstream cellular responses clearly sets Fusarium apart from other Ascomycetes. Although the functions of many of these kinases are still unclear, their specific proliferation highlights them as a result of the evolutionary forces that have shaped this species complex and clearly marks them as targets for exploitation in order to combat disease.Gregory A. DeIulioLi GuoYong ZhangJonathan M. GoldbergH. Corby KistlerLi-Jun MaAmerican Society for MicrobiologyarticleFusarium oxysporum species complexTOR kinaseaccessory chromosomehistidine kinasekinomeMicrobiologyQR1-502ENmSphere, Vol 3, Iss 3 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fusarium oxysporum species complex TOR kinase accessory chromosome histidine kinase kinome Microbiology QR1-502
spellingShingle	Fusarium oxysporum species complex TOR kinase accessory chromosome histidine kinase kinome Microbiology QR1-502 Gregory A. DeIulio Li Guo Yong Zhang Jonathan M. Goldberg H. Corby Kistler Li-Jun Ma Kinome Expansion in the <named-content content-type="genus-species">Fusarium oxysporum</named-content> Species Complex Driven by Accessory Chromosomes
description	ABSTRACT The Fusarium oxysporum species complex (FOSC) is a group of soilborne pathogens causing severe disease in more than 100 plant hosts, while individual strains exhibit strong host specificity. Both chromosome transfer and comparative genomics experiments have demonstrated that lineage-specific (LS) chromosomes contribute to the host-specific pathogenicity. However, little is known about the functional importance of genes encoded in these LS chromosomes. Focusing on signaling transduction, this study compared the kinomes of 12 F. oxysporum isolates, including both plant and human pathogens and 1 nonpathogenic biocontrol strain, with 7 additional publicly available ascomycete genomes. Overall, F. oxysporum kinomes are the largest, facilitated in part by the acquisitions of the LS chromosomes. The comparative study identified 99 kinases that are present in almost all examined fungal genomes, forming the core signaling network of ascomycete fungi. Compared to the conserved ascomycete kinome, the expansion of the F. oxysporum kinome occurs in several kinase families such as histidine kinases that are involved in environmental signal sensing and target of rapamycin (TOR) kinase that mediates cellular responses. Comparative kinome analysis suggests a convergent evolution that shapes individual F. oxysporum isolates with an enhanced and unique capacity for environmental perception and associated downstream responses. IMPORTANCE Isolates of Fusarium oxysporum are adapted to survive a wide range of host and nonhost conditions. In addition, F. oxysporum was recently recognized as the top emerging opportunistic fungal pathogen infecting immunocompromised humans. The sensory and response networks of these fungi undoubtedly play a fundamental role in establishing the adaptability of this group. We have examined the kinomes of 12 F. oxysporum isolates and highlighted kinase families that distinguish F. oxysporum from other fungi, as well as different isolates from one another. The amplification of kinases involved in environmental signal relay and regulating downstream cellular responses clearly sets Fusarium apart from other Ascomycetes. Although the functions of many of these kinases are still unclear, their specific proliferation highlights them as a result of the evolutionary forces that have shaped this species complex and clearly marks them as targets for exploitation in order to combat disease.
format	article
author	Gregory A. DeIulio Li Guo Yong Zhang Jonathan M. Goldberg H. Corby Kistler Li-Jun Ma
author_facet	Gregory A. DeIulio Li Guo Yong Zhang Jonathan M. Goldberg H. Corby Kistler Li-Jun Ma
author_sort	Gregory A. DeIulio
title	Kinome Expansion in the <named-content content-type="genus-species">Fusarium oxysporum</named-content> Species Complex Driven by Accessory Chromosomes
title_short	Kinome Expansion in the <named-content content-type="genus-species">Fusarium oxysporum</named-content> Species Complex Driven by Accessory Chromosomes
title_full	Kinome Expansion in the <named-content content-type="genus-species">Fusarium oxysporum</named-content> Species Complex Driven by Accessory Chromosomes
title_fullStr	Kinome Expansion in the <named-content content-type="genus-species">Fusarium oxysporum</named-content> Species Complex Driven by Accessory Chromosomes
title_full_unstemmed	Kinome Expansion in the <named-content content-type="genus-species">Fusarium oxysporum</named-content> Species Complex Driven by Accessory Chromosomes
title_sort	kinome expansion in the <named-content content-type="genus-species">fusarium oxysporum</named-content> species complex driven by accessory chromosomes
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/d9a664ae35754c9e924e404b9e2e71bf
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Kinome Expansion in the <named-content content-type="genus-species">Fusarium oxysporum</named-content> Species Complex Driven by Accessory Chromosomes

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