Ethylene, an early marker of systemic inflammation in humans

Abstract Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy...

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Autores principales:	Laurent M. Paardekooper, Geert van den Bogaart, Matthijs Kox, Ilse Dingjan, Anne H. Neerincx, Maura B. Bendix, Martin ter Beest, Frans J. M. Harren, Terence Risby, Peter Pickkers, Nandor Marczin, Simona M. Cristescu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9a802f93af543d483e64381ac7b1581
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id	oai:doaj.org-article:d9a802f93af543d483e64381ac7b1581
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spelling	oai:doaj.org-article:d9a802f93af543d483e64381ac7b15812021-12-02T15:05:43ZEthylene, an early marker of systemic inflammation in humans10.1038/s41598-017-05930-92045-2322https://doaj.org/article/d9a802f93af543d483e64381ac7b15812017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05930-9https://doaj.org/toc/2045-2322Abstract Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy both in vitro in isolated blood leukocytes exposed to bacterial lipopolysaccharide (LPS) as well as in vivo following LPS administration in healthy volunteers. Exposure to LPS triggers formation of ethylene as a product of lipid peroxidation induced by the respiratory burst. In humans, ethylene was detected prior to the increase of blood levels of inflammatory cytokines and stress-related hormones. Our results highlight that ethylene release is an early and integral component of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial infection.Laurent M. PaardekooperGeert van den BogaartMatthijs KoxIlse DingjanAnne H. NeerincxMaura B. BendixMartin ter BeestFrans J. M. HarrenTerence RisbyPeter PickkersNandor MarczinSimona M. CristescuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laurent M. Paardekooper Geert van den Bogaart Matthijs Kox Ilse Dingjan Anne H. Neerincx Maura B. Bendix Martin ter Beest Frans J. M. Harren Terence Risby Peter Pickkers Nandor Marczin Simona M. Cristescu Ethylene, an early marker of systemic inflammation in humans
description	Abstract Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy both in vitro in isolated blood leukocytes exposed to bacterial lipopolysaccharide (LPS) as well as in vivo following LPS administration in healthy volunteers. Exposure to LPS triggers formation of ethylene as a product of lipid peroxidation induced by the respiratory burst. In humans, ethylene was detected prior to the increase of blood levels of inflammatory cytokines and stress-related hormones. Our results highlight that ethylene release is an early and integral component of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial infection.
format	article
author	Laurent M. Paardekooper Geert van den Bogaart Matthijs Kox Ilse Dingjan Anne H. Neerincx Maura B. Bendix Martin ter Beest Frans J. M. Harren Terence Risby Peter Pickkers Nandor Marczin Simona M. Cristescu
author_facet	Laurent M. Paardekooper Geert van den Bogaart Matthijs Kox Ilse Dingjan Anne H. Neerincx Maura B. Bendix Martin ter Beest Frans J. M. Harren Terence Risby Peter Pickkers Nandor Marczin Simona M. Cristescu
author_sort	Laurent M. Paardekooper
title	Ethylene, an early marker of systemic inflammation in humans
title_short	Ethylene, an early marker of systemic inflammation in humans
title_full	Ethylene, an early marker of systemic inflammation in humans
title_fullStr	Ethylene, an early marker of systemic inflammation in humans
title_full_unstemmed	Ethylene, an early marker of systemic inflammation in humans
title_sort	ethylene, an early marker of systemic inflammation in humans
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d9a802f93af543d483e64381ac7b1581
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_version_	1718388737412431872

Ethylene, an early marker of systemic inflammation in humans

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