High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa.

As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and HPV types distribution among the unvaccinated population. Information on the prevalence of HPV and the distribution of HPV types in adolescents and young women i...

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Autores principales:	Zizipho Z A Mbulawa, Nontuthuzelo I Somdyala, Sikhumbuzo A Mabunda, Anna-Lise Williamson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9aaab34a22943e39212a81e76fdf989
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spelling	oai:doaj.org-article:d9aaab34a22943e39212a81e76fdf9892021-12-02T20:07:05ZHigh human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa.1932-620310.1371/journal.pone.0253074https://doaj.org/article/d9aaab34a22943e39212a81e76fdf9892021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253074https://doaj.org/toc/1932-6203As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and HPV types distribution among the unvaccinated population. Information on the prevalence of HPV and the distribution of HPV types in adolescents and young women in South Africa's Eastern Cape Province is minimal. Therefore, this study investigates the prevalence, distribution of HPV types, and factors associated with HPV infection amongst unvaccinated female learners. A sample composed of 213 sexually active female learners attending high schools in the Eastern Cape Province of South Africa; median age 18 years, who provided self-collected vaginal specimens. Roche Linear Array HPV genotyping assay that detects 37 HPV genotypes was used to detect HPV infection. HPV infection was detected in 76.06% (162/213) of participants. Of these 14.55% (31/213) were positive for HPV types targeted by the Cervarix® HPV vaccine (HPV-16 and/or 18), 20.66% (44/213) by Gardasil®4 (HPV-6, -11, -16 and/or -18) and 37.09% (79/213) by Gardasil®9 (HPV-6, -11, -16, -18, -31, -33, -45, -52 and/or -58). HPV-35, commonly detected in cervical cancer cases among women of African ancestry, was frequently detected (9.40%). Participants who reported to have ever consumed alcohol had a significantly higher risk of HPV infection (OR: 2.91, 95% CI: 1.38-6.11, p = 0.005). High HPV prevalence was observed among participants. The high prevalence of HPV types targeted by the Gardasil®9 vaccine encourages the introduction of the Gardasil®9 vaccine. Data from this study will inform both vaccination campaigns and monitor the impact on HPV types after vaccination.Zizipho Z A MbulawaNontuthuzelo I SomdyalaSikhumbuzo A MabundaAnna-Lise WilliamsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253074 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zizipho Z A Mbulawa Nontuthuzelo I Somdyala Sikhumbuzo A Mabunda Anna-Lise Williamson High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa.
description	As part of the human papillomavirus (HPV) vaccination strategy in South Africa, it is essential to have information on HPV prevalence, and HPV types distribution among the unvaccinated population. Information on the prevalence of HPV and the distribution of HPV types in adolescents and young women in South Africa's Eastern Cape Province is minimal. Therefore, this study investigates the prevalence, distribution of HPV types, and factors associated with HPV infection amongst unvaccinated female learners. A sample composed of 213 sexually active female learners attending high schools in the Eastern Cape Province of South Africa; median age 18 years, who provided self-collected vaginal specimens. Roche Linear Array HPV genotyping assay that detects 37 HPV genotypes was used to detect HPV infection. HPV infection was detected in 76.06% (162/213) of participants. Of these 14.55% (31/213) were positive for HPV types targeted by the Cervarix® HPV vaccine (HPV-16 and/or 18), 20.66% (44/213) by Gardasil®4 (HPV-6, -11, -16 and/or -18) and 37.09% (79/213) by Gardasil®9 (HPV-6, -11, -16, -18, -31, -33, -45, -52 and/or -58). HPV-35, commonly detected in cervical cancer cases among women of African ancestry, was frequently detected (9.40%). Participants who reported to have ever consumed alcohol had a significantly higher risk of HPV infection (OR: 2.91, 95% CI: 1.38-6.11, p = 0.005). High HPV prevalence was observed among participants. The high prevalence of HPV types targeted by the Gardasil®9 vaccine encourages the introduction of the Gardasil®9 vaccine. Data from this study will inform both vaccination campaigns and monitor the impact on HPV types after vaccination.
format	article
author	Zizipho Z A Mbulawa Nontuthuzelo I Somdyala Sikhumbuzo A Mabunda Anna-Lise Williamson
author_facet	Zizipho Z A Mbulawa Nontuthuzelo I Somdyala Sikhumbuzo A Mabunda Anna-Lise Williamson
author_sort	Zizipho Z A Mbulawa
title	High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa.
title_short	High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa.
title_full	High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa.
title_fullStr	High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa.
title_full_unstemmed	High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa.
title_sort	high human papillomavirus prevalence among females attending high school in the eastern cape province of south africa.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d9aaab34a22943e39212a81e76fdf989
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High human papillomavirus prevalence among females attending high school in the Eastern Cape Province of South Africa.

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