Synaptic Loss in Multiple Sclerosis: A Systematic Review of Human Post-mortem Studies

Background: Gray matter pathology plays a central role in the progression of multiple sclerosis (MS). The occurrence of synaptic loss appears to be important but, to date, still poorly investigated aspect of MS pathology. In this systematic review, we drew from the recent knowledge about synaptic lo...

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Autores principales:	E. E. Amelie Möck, Eveliina Honkonen, Laura Airas
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	synapses synaptic density synaptic loss gray matter multiple sclerosis review Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d9ab4e7a282c4356ba6931d7de350788
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spelling	oai:doaj.org-article:d9ab4e7a282c4356ba6931d7de3507882021-12-01T11:02:49ZSynaptic Loss in Multiple Sclerosis: A Systematic Review of Human Post-mortem Studies1664-229510.3389/fneur.2021.782599https://doaj.org/article/d9ab4e7a282c4356ba6931d7de3507882021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.782599/fullhttps://doaj.org/toc/1664-2295Background: Gray matter pathology plays a central role in the progression of multiple sclerosis (MS). The occurrence of synaptic loss appears to be important but, to date, still poorly investigated aspect of MS pathology. In this systematic review, we drew from the recent knowledge about synaptic loss in human post-mortem studies.Methods: We conducted a systematic search with PubMed to identify relevant publications. Publications available from15 June 2021 were taken into account. We selected human post-mortem studies that quantitatively assessed the synapse number in MS tissue.Results: We identified 14 relevant publications out of which 9 reported synaptic loss in at least one investigated subregion. The most commonly used synaptic marker was synaptophysin; non-etheless, we found substantial differences in the methodology and the selection of reference tissue. Investigated regions included the cortex, the hippocampus, the cerebellum, the thalamus, and the spinal cord.Conclusion: Synaptic loss seems to take place throughout the entire central nervous system. However, the results are inconsistent, probably due to differences in the methodology. Moreover, synaptic loss appears to be a dynamic process, and thus the nature of this pathology might be captured using in vivo synaptic density measurements.E. E. Amelie MöckE. E. Amelie MöckEveliina HonkonenEveliina HonkonenLaura AirasLaura AirasFrontiers Media S.A.articlesynapsessynaptic densitysynaptic lossgray mattermultiple sclerosisreviewNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	synapses synaptic density synaptic loss gray matter multiple sclerosis review Neurology. Diseases of the nervous system RC346-429
spellingShingle	synapses synaptic density synaptic loss gray matter multiple sclerosis review Neurology. Diseases of the nervous system RC346-429 E. E. Amelie Möck E. E. Amelie Möck Eveliina Honkonen Eveliina Honkonen Laura Airas Laura Airas Synaptic Loss in Multiple Sclerosis: A Systematic Review of Human Post-mortem Studies
description	Background: Gray matter pathology plays a central role in the progression of multiple sclerosis (MS). The occurrence of synaptic loss appears to be important but, to date, still poorly investigated aspect of MS pathology. In this systematic review, we drew from the recent knowledge about synaptic loss in human post-mortem studies.Methods: We conducted a systematic search with PubMed to identify relevant publications. Publications available from15 June 2021 were taken into account. We selected human post-mortem studies that quantitatively assessed the synapse number in MS tissue.Results: We identified 14 relevant publications out of which 9 reported synaptic loss in at least one investigated subregion. The most commonly used synaptic marker was synaptophysin; non-etheless, we found substantial differences in the methodology and the selection of reference tissue. Investigated regions included the cortex, the hippocampus, the cerebellum, the thalamus, and the spinal cord.Conclusion: Synaptic loss seems to take place throughout the entire central nervous system. However, the results are inconsistent, probably due to differences in the methodology. Moreover, synaptic loss appears to be a dynamic process, and thus the nature of this pathology might be captured using in vivo synaptic density measurements.
format	article
author	E. E. Amelie Möck E. E. Amelie Möck Eveliina Honkonen Eveliina Honkonen Laura Airas Laura Airas
author_facet	E. E. Amelie Möck E. E. Amelie Möck Eveliina Honkonen Eveliina Honkonen Laura Airas Laura Airas
author_sort	E. E. Amelie Möck
title	Synaptic Loss in Multiple Sclerosis: A Systematic Review of Human Post-mortem Studies
title_short	Synaptic Loss in Multiple Sclerosis: A Systematic Review of Human Post-mortem Studies
title_full	Synaptic Loss in Multiple Sclerosis: A Systematic Review of Human Post-mortem Studies
title_fullStr	Synaptic Loss in Multiple Sclerosis: A Systematic Review of Human Post-mortem Studies
title_full_unstemmed	Synaptic Loss in Multiple Sclerosis: A Systematic Review of Human Post-mortem Studies
title_sort	synaptic loss in multiple sclerosis: a systematic review of human post-mortem studies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d9ab4e7a282c4356ba6931d7de350788
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Synaptic Loss in Multiple Sclerosis: A Systematic Review of Human Post-mortem Studies

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