Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders

Abstract Motor neuron disorders (MND) include a group of pathologies that affect upper and/or lower motor neurons. Among them, amyotrophic lateral sclerosis (ALS) is characterized by progressive muscle weakness, with fatal outcomes only in a few years after diagnosis. On the other hand, primary late...

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Autores principales:	Estela Area-Gomez, D. Larrea, T. Yun, Y. Xu, J. Hupf, F. Zandkarimi, R. B. Chan, H. Mitsumoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9ac3cd69e5d4df1afc469dd47aa55ca
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spelling	oai:doaj.org-article:d9ac3cd69e5d4df1afc469dd47aa55ca2021-12-02T16:32:08ZLipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders10.1038/s41598-021-92112-32045-2322https://doaj.org/article/d9ac3cd69e5d4df1afc469dd47aa55ca2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92112-3https://doaj.org/toc/2045-2322Abstract Motor neuron disorders (MND) include a group of pathologies that affect upper and/or lower motor neurons. Among them, amyotrophic lateral sclerosis (ALS) is characterized by progressive muscle weakness, with fatal outcomes only in a few years after diagnosis. On the other hand, primary lateral sclerosis (PLS), a more benign form of MND that only affects upper motor neurons, results in life-long progressive motor dysfunction. Although the outcomes are quite different, ALS and PLS present with similar symptoms at disease onset, to the degree that both disorders could be considered part of a continuum. These similarities and the lack of reliable biomarkers often result in delays in accurate diagnosis and/or treatment. In the nervous system, lipids exert a wide variety of functions, including roles in cell structure, synaptic transmission, and multiple metabolic processes. Thus, the study of the absolute and relative concentrations of a subset of lipids in human pathology can shed light into these cellular processes and unravel alterations in one or more pathways. In here, we report the lipid composition of longitudinal plasma samples from ALS and PLS patients initially, and after 2 years following enrollment in a clinical study. Our analysis revealed common aspects of these pathologies suggesting that, from the lipidomics point of view, PLS and ALS behave as part of a continuum of motor neuron disorders.Estela Area-GomezD. LarreaT. YunY. XuJ. HupfF. ZandkarimiR. B. ChanH. MitsumotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Estela Area-Gomez D. Larrea T. Yun Y. Xu J. Hupf F. Zandkarimi R. B. Chan H. Mitsumoto Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders
description	Abstract Motor neuron disorders (MND) include a group of pathologies that affect upper and/or lower motor neurons. Among them, amyotrophic lateral sclerosis (ALS) is characterized by progressive muscle weakness, with fatal outcomes only in a few years after diagnosis. On the other hand, primary lateral sclerosis (PLS), a more benign form of MND that only affects upper motor neurons, results in life-long progressive motor dysfunction. Although the outcomes are quite different, ALS and PLS present with similar symptoms at disease onset, to the degree that both disorders could be considered part of a continuum. These similarities and the lack of reliable biomarkers often result in delays in accurate diagnosis and/or treatment. In the nervous system, lipids exert a wide variety of functions, including roles in cell structure, synaptic transmission, and multiple metabolic processes. Thus, the study of the absolute and relative concentrations of a subset of lipids in human pathology can shed light into these cellular processes and unravel alterations in one or more pathways. In here, we report the lipid composition of longitudinal plasma samples from ALS and PLS patients initially, and after 2 years following enrollment in a clinical study. Our analysis revealed common aspects of these pathologies suggesting that, from the lipidomics point of view, PLS and ALS behave as part of a continuum of motor neuron disorders.
format	article
author	Estela Area-Gomez D. Larrea T. Yun Y. Xu J. Hupf F. Zandkarimi R. B. Chan H. Mitsumoto
author_facet	Estela Area-Gomez D. Larrea T. Yun Y. Xu J. Hupf F. Zandkarimi R. B. Chan H. Mitsumoto
author_sort	Estela Area-Gomez
title	Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders
title_short	Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders
title_full	Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders
title_fullStr	Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders
title_full_unstemmed	Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders
title_sort	lipidomics study of plasma from patients suggest that als and pls are part of a continuum of motor neuron disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d9ac3cd69e5d4df1afc469dd47aa55ca
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Lipidomics study of plasma from patients suggest that ALS and PLS are part of a continuum of motor neuron disorders

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