Patterns of acute inflammatory symptoms prior to cancer diagnosis

Abstract Although many studies have examined the role of chronic inflammation in cancer development, few studies discuss the patterns of acute inflammation prior to cancer diagnosis. Patients with lung, colorectal, prostate, or breast cancer between 1 July 2006 and 31 December 2009 and their metasta...

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Autores principales:	Andrea Setiawan, Li Yin, Gert Auer, Kamila Czene, Karin E. Smedby, Yudi Pawitan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9ac45cba57c49989b175d28c9aa4193
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spelling	oai:doaj.org-article:d9ac45cba57c49989b175d28c9aa41932021-12-02T16:06:55ZPatterns of acute inflammatory symptoms prior to cancer diagnosis10.1038/s41598-017-00133-82045-2322https://doaj.org/article/d9ac45cba57c49989b175d28c9aa41932017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00133-8https://doaj.org/toc/2045-2322Abstract Although many studies have examined the role of chronic inflammation in cancer development, few studies discuss the patterns of acute inflammation prior to cancer diagnosis. Patients with lung, colorectal, prostate, or breast cancer between 1 July 2006 and 31 December 2009 and their metastatic status at diagnosis were determined through the Swedish Cancer Register. Non-steroidal anti-inflammatory drugs (NSAIDs) use in the year prior to cancer diagnosis was assessed through the Swedish Prescribed Drug Register. There were 13,945 patients identified with breast cancer, 6501 with prostate cancer, 5508 with lung cancer, and 12,723 with colon cancer. For metastatic patients, there is strong evidence of higher NSAIDs use 1–3 months compared to 10–12 months prior to diagnosis (breast odds ratio (OR) = 3.54, 95% CI 2.26–5.54; prostate OR = 3.90, 95% CI 3.10–4.90; lung OR = 2.90 95% CI 2.44–3.44; colorectal OR = 1.67, 95% CI 1.36–2.05). For non-metastatic patients, increased NSAIDs use 1–3 months prior to diagnosis was also observed, but only to a smaller extent for lung and prostate cancer (prostate OR = 1.48, 95% CI 1.27–1.72; lung 1.41, 95% CI 1.19–1.67). In conclusion, if NSAIDs use reflects underlying inflammatory symptoms, there is support for the hypothesis that advanced cancer was associated with an acute inflammatory process.Andrea SetiawanLi YinGert AuerKamila CzeneKarin E. SmedbyYudi PawitanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrea Setiawan Li Yin Gert Auer Kamila Czene Karin E. Smedby Yudi Pawitan Patterns of acute inflammatory symptoms prior to cancer diagnosis
description	Abstract Although many studies have examined the role of chronic inflammation in cancer development, few studies discuss the patterns of acute inflammation prior to cancer diagnosis. Patients with lung, colorectal, prostate, or breast cancer between 1 July 2006 and 31 December 2009 and their metastatic status at diagnosis were determined through the Swedish Cancer Register. Non-steroidal anti-inflammatory drugs (NSAIDs) use in the year prior to cancer diagnosis was assessed through the Swedish Prescribed Drug Register. There were 13,945 patients identified with breast cancer, 6501 with prostate cancer, 5508 with lung cancer, and 12,723 with colon cancer. For metastatic patients, there is strong evidence of higher NSAIDs use 1–3 months compared to 10–12 months prior to diagnosis (breast odds ratio (OR) = 3.54, 95% CI 2.26–5.54; prostate OR = 3.90, 95% CI 3.10–4.90; lung OR = 2.90 95% CI 2.44–3.44; colorectal OR = 1.67, 95% CI 1.36–2.05). For non-metastatic patients, increased NSAIDs use 1–3 months prior to diagnosis was also observed, but only to a smaller extent for lung and prostate cancer (prostate OR = 1.48, 95% CI 1.27–1.72; lung 1.41, 95% CI 1.19–1.67). In conclusion, if NSAIDs use reflects underlying inflammatory symptoms, there is support for the hypothesis that advanced cancer was associated with an acute inflammatory process.
format	article
author	Andrea Setiawan Li Yin Gert Auer Kamila Czene Karin E. Smedby Yudi Pawitan
author_facet	Andrea Setiawan Li Yin Gert Auer Kamila Czene Karin E. Smedby Yudi Pawitan
author_sort	Andrea Setiawan
title	Patterns of acute inflammatory symptoms prior to cancer diagnosis
title_short	Patterns of acute inflammatory symptoms prior to cancer diagnosis
title_full	Patterns of acute inflammatory symptoms prior to cancer diagnosis
title_fullStr	Patterns of acute inflammatory symptoms prior to cancer diagnosis
title_full_unstemmed	Patterns of acute inflammatory symptoms prior to cancer diagnosis
title_sort	patterns of acute inflammatory symptoms prior to cancer diagnosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d9ac45cba57c49989b175d28c9aa4193
work_keys_str_mv	AT andreasetiawan patternsofacuteinflammatorysymptomspriortocancerdiagnosis AT liyin patternsofacuteinflammatorysymptomspriortocancerdiagnosis AT gertauer patternsofacuteinflammatorysymptomspriortocancerdiagnosis AT kamilaczene patternsofacuteinflammatorysymptomspriortocancerdiagnosis AT karinesmedby patternsofacuteinflammatorysymptomspriortocancerdiagnosis AT yudipawitan patternsofacuteinflammatorysymptomspriortocancerdiagnosis
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Patterns of acute inflammatory symptoms prior to cancer diagnosis

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