Discovering de novo peptide substrates for enzymes using machine learning

The discovery of peptide substrates for enzymes with selective activities is a central goal in chemical biology. Here, the authors develop a hybrid method combining machine learning and experimental testing for fast optimization of peptides for specific, orthogononal functions.

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Auteurs principaux:	Lorillee Tallorin, JiaLei Wang, Woojoo E. Kim, Swagat Sahu, Nicolas M. Kosa, Pu Yang, Matthew Thompson, Michael K. Gilson, Peter I. Frazier, Michael D. Burkart, Nathan C. Gianneschi
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/d9ae7a50ccf5436cb95b497dfe663903
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spelling	oai:doaj.org-article:d9ae7a50ccf5436cb95b497dfe6639032021-12-02T14:40:54ZDiscovering de novo peptide substrates for enzymes using machine learning10.1038/s41467-018-07717-62041-1723https://doaj.org/article/d9ae7a50ccf5436cb95b497dfe6639032018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07717-6https://doaj.org/toc/2041-1723The discovery of peptide substrates for enzymes with selective activities is a central goal in chemical biology. Here, the authors develop a hybrid method combining machine learning and experimental testing for fast optimization of peptides for specific, orthogononal functions.Lorillee TallorinJiaLei WangWoojoo E. KimSwagat SahuNicolas M. KosaPu YangMatthew ThompsonMichael K. GilsonPeter I. FrazierMichael D. BurkartNathan C. GianneschiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lorillee Tallorin JiaLei Wang Woojoo E. Kim Swagat Sahu Nicolas M. Kosa Pu Yang Matthew Thompson Michael K. Gilson Peter I. Frazier Michael D. Burkart Nathan C. Gianneschi Discovering de novo peptide substrates for enzymes using machine learning
description	The discovery of peptide substrates for enzymes with selective activities is a central goal in chemical biology. Here, the authors develop a hybrid method combining machine learning and experimental testing for fast optimization of peptides for specific, orthogononal functions.
format	article
author	Lorillee Tallorin JiaLei Wang Woojoo E. Kim Swagat Sahu Nicolas M. Kosa Pu Yang Matthew Thompson Michael K. Gilson Peter I. Frazier Michael D. Burkart Nathan C. Gianneschi
author_facet	Lorillee Tallorin JiaLei Wang Woojoo E. Kim Swagat Sahu Nicolas M. Kosa Pu Yang Matthew Thompson Michael K. Gilson Peter I. Frazier Michael D. Burkart Nathan C. Gianneschi
author_sort	Lorillee Tallorin
title	Discovering de novo peptide substrates for enzymes using machine learning
title_short	Discovering de novo peptide substrates for enzymes using machine learning
title_full	Discovering de novo peptide substrates for enzymes using machine learning
title_fullStr	Discovering de novo peptide substrates for enzymes using machine learning
title_full_unstemmed	Discovering de novo peptide substrates for enzymes using machine learning
title_sort	discovering de novo peptide substrates for enzymes using machine learning
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d9ae7a50ccf5436cb95b497dfe663903
work_keys_str_mv	AT lorilleetallorin discoveringdenovopeptidesubstratesforenzymesusingmachinelearning AT jialeiwang discoveringdenovopeptidesubstratesforenzymesusingmachinelearning AT woojooekim discoveringdenovopeptidesubstratesforenzymesusingmachinelearning AT swagatsahu discoveringdenovopeptidesubstratesforenzymesusingmachinelearning AT nicolasmkosa discoveringdenovopeptidesubstratesforenzymesusingmachinelearning AT puyang discoveringdenovopeptidesubstratesforenzymesusingmachinelearning AT matthewthompson discoveringdenovopeptidesubstratesforenzymesusingmachinelearning AT michaelkgilson discoveringdenovopeptidesubstratesforenzymesusingmachinelearning AT peterifrazier discoveringdenovopeptidesubstratesforenzymesusingmachinelearning AT michaeldburkart discoveringdenovopeptidesubstratesforenzymesusingmachinelearning AT nathancgianneschi discoveringdenovopeptidesubstratesforenzymesusingmachinelearning
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Discovering de novo peptide substrates for enzymes using machine learning

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