Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex

Abstract The broadly-distributed, non-topographic projections to and from the olfactory cortex may suggest a flat, non-hierarchical organization in odor information processing. Layer 2 principal neurons in the anterior piriform cortex (APC) can be divided into 2 subtypes: semilunar (SL) and superfic...

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Autores principales:	Camille Mazo, Julien Grimaud, Yasuyuki Shima, Venkatesh N. Murthy, C. Geoffrey Lau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d9af514afbe8412ab7af1d59057dfd20
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spelling	oai:doaj.org-article:d9af514afbe8412ab7af1d59057dfd202021-12-02T15:05:18ZDistinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex10.1038/s41598-017-08331-02045-2322https://doaj.org/article/d9af514afbe8412ab7af1d59057dfd202017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08331-0https://doaj.org/toc/2045-2322Abstract The broadly-distributed, non-topographic projections to and from the olfactory cortex may suggest a flat, non-hierarchical organization in odor information processing. Layer 2 principal neurons in the anterior piriform cortex (APC) can be divided into 2 subtypes: semilunar (SL) and superficial pyramidal (SP) cells. Although it is known that SL and SP cells receive differential inputs from the olfactory bulb (OB), little is known about their projections to other olfactory regions. Here, we examined axonal projections of SL and SP cells using a combination of mouse genetics and retrograde labeling. Retrograde tracing from the OB or posterior piriform cortex (PPC) showed that the APC projects to these brain regions mainly through layer 2b cells, and dual-labeling revealed many cells extending collaterals to both target regions. Furthermore, a transgenic mouse line specifically labeling SL cells showed that they send profuse axonal projections to olfactory cortical areas, but not to the OB. These findings support a model in which information flow from SL to SP cells and back to the OB is mediated by a hierarchical feedback circuit, whereas both SL and SP cells broadcast information to higher olfactory areas in a parallel manner.Camille MazoJulien GrimaudYasuyuki ShimaVenkatesh N. MurthyC. Geoffrey LauNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Camille Mazo Julien Grimaud Yasuyuki Shima Venkatesh N. Murthy C. Geoffrey Lau Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex
description	Abstract The broadly-distributed, non-topographic projections to and from the olfactory cortex may suggest a flat, non-hierarchical organization in odor information processing. Layer 2 principal neurons in the anterior piriform cortex (APC) can be divided into 2 subtypes: semilunar (SL) and superficial pyramidal (SP) cells. Although it is known that SL and SP cells receive differential inputs from the olfactory bulb (OB), little is known about their projections to other olfactory regions. Here, we examined axonal projections of SL and SP cells using a combination of mouse genetics and retrograde labeling. Retrograde tracing from the OB or posterior piriform cortex (PPC) showed that the APC projects to these brain regions mainly through layer 2b cells, and dual-labeling revealed many cells extending collaterals to both target regions. Furthermore, a transgenic mouse line specifically labeling SL cells showed that they send profuse axonal projections to olfactory cortical areas, but not to the OB. These findings support a model in which information flow from SL to SP cells and back to the OB is mediated by a hierarchical feedback circuit, whereas both SL and SP cells broadcast information to higher olfactory areas in a parallel manner.
format	article
author	Camille Mazo Julien Grimaud Yasuyuki Shima Venkatesh N. Murthy C. Geoffrey Lau
author_facet	Camille Mazo Julien Grimaud Yasuyuki Shima Venkatesh N. Murthy C. Geoffrey Lau
author_sort	Camille Mazo
title	Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex
title_short	Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex
title_full	Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex
title_fullStr	Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex
title_full_unstemmed	Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex
title_sort	distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d9af514afbe8412ab7af1d59057dfd20
work_keys_str_mv	AT camillemazo distinctprojectionpatternsofdifferentclassesoflayer2principalneuronsintheolfactorycortex AT juliengrimaud distinctprojectionpatternsofdifferentclassesoflayer2principalneuronsintheolfactorycortex AT yasuyukishima distinctprojectionpatternsofdifferentclassesoflayer2principalneuronsintheolfactorycortex AT venkateshnmurthy distinctprojectionpatternsofdifferentclassesoflayer2principalneuronsintheolfactorycortex AT cgeoffreylau distinctprojectionpatternsofdifferentclassesoflayer2principalneuronsintheolfactorycortex
_version_	1718388925101244416

Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex

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